Laparoscopic salpingectomy or hysteroscopic tubal occlusion in patients with hydrosalpinx and intracytoplasmic sperm injection outcomes

Background: Tubal factor of infertility resulting from various forms of tub peritoneal damage remains an extremely common cause of female infertility. Probably the most severe form of tubal pathology is hydrosalpinx. Objectives: To compare the efficacy of hysteroscopic tubal electrocoagulation versus laparoscopic salpingectomy for management of hydrosalpinx related infertility among patients undergoing intracytoplasmic sperm injection (ICSI).Patients and Methods: This retrospective study was conducted at outpatient clinic in Private Infertility Unit, Menoufia, Egypt, from November 2018 to August 2019. This study included 120 infertile patients who were candidate for ICSI and fulfilled inclusion and exclusion criteria, half of the patients underwent hysteroscopic tubal electrocoagulation who have laparoscopic contraindications, while the other half underwent laparoscopic salpingectomy. After tubal occlusion was done, an ICSI cycle was started with assessment of chemical pregnancy rate. Results: The rate of positive chemical pregnancy was 56.16% in hysteroscopic group and 43.84% in laparoscopic group. Conclusion: Hysteroscopic tubal electrocoagulation was found to be a successful treatment for hydrosalpinges before ICSI when laparoscopy is contraindicated with chemical pregnancy rate comparable to laparoscopic tubal disconnection

Validation of a modified cow’s milk-related symptom score (CoMISS) for screening of lactose intolerance in adults

Introduction: Lactose intolerance (LI) is the failure to digest foods and beverages containing the lactose present in milk. LI can present by many digestive symptoms. Objective: To validate the modified CoMiSS score for prediction of LI, that was confirmed by a stool acidity test. Patients and methods: A cross-sectional study, was conducted at Ain Shams University Hospitals/Gastrointestinal Clinics, and included one hundred adult participants during the period from December 2018 to December 2019. Enrolled patients had one or more gastrointestinal symptoms and were subjected to a stool acidity test (fecal PH test) as a reference test and modified CoMiSS as an index test. Results: The mean age of participants was 35.30 ± 10.714 years old; 55% were females, and their mean body mass index (BMI) was 23.08 ± 2.080 kg/m2, with no significant relation between LI and patients` gender or BMI. Out of the studied participants 24% had positive stool PH, LI diagnosed according to modified CoMISS was present among 19% of them. The mean value of modified CoMISS Score was significantly higher in positive cases (12.37) compared to negative LI participants (2.33) as p < .001. Area under ROC Curve was 0.998, at the selected cut-off value 8, the sensitivity was 89.5% and specificity was 100% thus, levels of questionnaire scoring of 8 or higher would indicate presence of lactose intolerance. Conclusion: Modified CoMiSS is a simple, fast, and easy-to-use tool that can predict LI, with a cut-off value of >8, the Area under the ROC Curve was 0.998, sensitivity 89.5%, and specificity was 100%

Comparative evaluation of solvent extracts of Azanza garckeana fruit pulp on hormonal profiles, spermiogram and antioxidant activities in rabbit bucks

[EN] The study investigated the comparative influence of different extraction solvents on spermiogram, hormonal profiles and antioxidant activities in rabbit bucks. Adult New Zealand White rabbit bucks (n=18), with average live weight of 1.2±0.03 kg and aged 10-18 mo were fed ad libitum on a commercial diet. They were administered five different Azanza garckeana (AG) fruit pulp extracts at 500 mg/kg via oral gavage, comprising control group (Con), crude (AG Cr), methanol (AG M), n-hexane (AG H), ethyl acetate (AG E) and aqueous (AG AQ) for four weeks. The extracts improved the spermiogram in rabbit bucks administered methanol (AG M) and the reaction time was significantly (P<0.05) lower in AG E group when compared to other groups. The ejaculate volume, sperm motility, pH and sperm concentration were significantly (P<0.05) higher in the AG M group when compared to the other groups. There was a significant (P<0.05) increase in concentrations of blood testosterone, follicle-stimulating hormone and luteinising hormone in methanol extract group (AG M). While the glutathione and malondialdehyde concentrations were (P<0.05) lower, catalase and superoxide dismutase activities were significantly (P<0.05) higher in the groups administered methanol extract (AG M). It was concluded that AG M extracts of AG pulp elicited the best response in spermiogram, hormonal concentrations and antioxidant activities in New Zealand White rabbit bucks. Its use as the extraction solvent is recommended.Itodo, JI.; Ayo, JO.; Rekwot, IP.; Aluwong, T.; Allam, L.; Ibrahim, S. (2022). Comparative evaluation of solvent extracts of Azanza garckeana fruit pulp on hormonal profiles, spermiogram and antioxidant activities in rabbit bucks. World Rabbit Science. 30(4):309-326. https://doi.org/10.4995/wrs.2022.1725630932630

Histopathological cancer detection based on deep learning and stain images

Colorectal cancer (CRC)-a malignant growth in the colon or rectum- is the second largest cause of cancer deaths worldwide. Early detection may increase therapy choices. Deep learning can improve early medical detection to reduce the risk of unintentional death from an incorrect clinical diagnosis. Histopathological examination of colon cancer is essential in medical research. This paper proposes a deep learning-based colon cancer detection method using stain-normalized images. We use deep learning methods to improve detection accuracy and efficiency. Our solution normalizes image stain variations and uses deep learning models for reliable classification. This research improves colon cancer histopathology analysis, which may enhance diagnosis. Our paper uses DenseNet-121, VGG-16, GoogLeNet, ResNet-50, and ResNet-18 deep learning models. We also analyze how stain normalization (SN) improves our model on histopathology images. The ResNet-50 model with SN yields the highest values (9.94%) compared to the other four models and the nine models from previous studies

Predictors of high calcium score in patients with negative myocardial perfusion imaging

Background: Coronary artery disease (CAD) is one of the major cardiovascular diseases. Myocardial perfusion imaging (MPI) using single photon emission computed tomography (SPECT) plays an important role in the diagnosis and prognosis of CAD.Objective: The aim of the present study was to reduce the generalization of doing calcium score for all coronary cardiac patients with negative myocardial perfusion imaging. Patients and methods: A retrospective cohort study analysis using data from Alfa Scan Center, a major outpatient radiology center in Cairo, Egypt, and conducted in Cardiology Department, Faculty of Medicine, Zagazig University that included a total sample of 1168 participants with negative myocardial perfusion imaging not known to have history of CAD, and age ranged between 20 to 80 years from both sexes. All patients were subjected for SPECT-MPI after the intravenous injection of 99mTc-sestamibi.Results: There was statistically significant difference between the two groups regarding age, gender, weight, chest pain, hypertension, dyslipidemia, diabetes, family history of CAD, beta blockers, aspirin, resting diastolic blood pressure (DBP), rest ECG abnormalities and exercise duration. Age, gender, diabetes mellitus and dyslipidemia were the predictors of any coronary artery calcification (CAC &gt; 0) in patients with negative myocardial perfusion imaging. Age, gender and Duke Treadmill Score were the predictors of significant coronary artery calcification (CAC &gt; 100) in patients with negative myocardial perfusion imaging.Conclusion: Calcium score for all not known coronary cardiac patients with negative MPI is a mandatory, particularly if they are old, male gender and have multiple risk factors

Comparative study of different incision types in inguinal lymphadenectomy: retrospective study

Background: Inguinal lymphadenectomy has always been associated with a high complication rate, mostly related to wound healing. Objectives: We aimed at evaluating the skin excision vertical incision in lowering wound complication rate following inguinal lymphadenectomy. Patients and Methods: Patients underwent inguinal lymphadenectomy for malignant nodal metastasis at the National Cancer Institute, Cairo University, Egypt in the period from January 2017 to December 2020. According to the incision type, we divided them into three groups: Group 1: vertical with vertical skin ellipse (~4cm) excision. Group 2: vertical S-shaped without skin excision.Group 3: transverse incision. We compared the short-term outcome among these groups. Results: Seventy-eight patients included, 27 (34.6%) G1, 27 (34.6% G2), and 24 (30.8%) G3. Complications occurred in a total of 20 cases (25.6% ). Its rate was highest in G3 (37.5% of cases) and least in G1 (14.8%). Flap necrosis was a common serious complication. It least occurred in the G1 Group and most in the G3 Group. No statistical difference was noticed regarding the median operation time, postoperative hospital stay, and median duration before drain removal. Capsular rupture did not occur in G1 patients, occurred only in one case of G2 (3.7%) and 2 cases of G3 ( 8.3%). Despite being statistically insignificant it is very significant oncologically. Conclusions: Vertical elliptical skin wedge excision in inguinal lymphadenectomy provides better surgical field exposure. It avoids direct handling of the tumor; thus is more safe oncologically. It has the least flap necrosis rate among other incision types

Study of Urinary Alpha Glutathione-S-Transferase in Children with Idiopathic Nephrotic Syndrome

Glomerulopathy associated with recurrent or persistent proteinuria may lead to progressive tubulointerstitial fibrosis. Early detection of tubulointerstitial fibrosis may result in a more favorable outcome of chronic kidney disease (CKD) because nephroprotective treatment may be instituted in due course. One of the early markers of tubulointerstitial fibrosis is glutathione S-transferase (GST). The aim of this study was to determine urinary alpha-GST in children with idiopathic nephrotic syndrome (INS), either in remission or relapse. This case–control study included 40 children with primary nephrotic syndrome (NS), either in remission or relapse. Also, 40 healthy children, age- and sex-matched as controls, were selected from the outpatients and the pediatric nephrology unit of Al-Zahraa Hospital, Al-Azhar University. Urinary alpha-GST was investigated in the study groups on the same lines as that of routine investigations of INS. Children with INS have significantly higher urinary GST either in remission or relapse, it was (5.23 ± 1.90) ng/mL, (5.32 ± 1.52) ng/mL respectively compared with healthy controls, it was (2.59 ± 1.12) ng/mL with (P = 0.001). A positive correlation between urinary alpha-GST and body weight BW, height, body mass index (BMI), white blood cells (WBCs) count, erythrocyte sedimentation rate, serum (cholesterol, triglyceride [TG]) level, blood urea nitrogen (BUN), and duration of the disease. Urinary alpha-GST was increased in children with NS even after remission, and it consequently led to oxidative stress and tubulointerstitial fibrosis. Nephroprotective treatment is recommended even in cases with INS, either in remission or relapse

The association of hamstring tightness with lumbar lordosis and trunk flexibility in healthy individuals: gender analysis

Objectives: The purpose of this study was to investigate if there is a relation between hamstring tightness and lumbar lordosis as well as trunk flexibility based on gender differences and to analyze the differences in hamstring tightness, lumber lordosis and trunk flexibility in healthy adults.Methods: One hundred young healthy adults were recruited and distributed into 2 equal groups according to gender: group A (female group) and group B (male group). Hamstring tightness (HT) was measured by Active Knee Extension (AKE) test and Straight Leg Raise (SLR) test, the angle of lumbar lordosis was measured with a flexible ruler from standing position and trunk flexion flexibility (TFF) was measured by Fingertip-to-Floor Test.Results: There was a significant correlation between TFF and both measures of HT (SLR, p = 0.001; AKE, p = 0.001) in females. While, there was a non-significant correlation in males (SLR, p = 0.900; AKE, p = 0.717). Moreover, there was a non-significant correlation between lumbar lordosis and HT measures in both groups as (p &gt; 0.05). Furthermore, there were significant differences between males and females in hamstring flexibility, TFF and lumbar lordosis as (p &lt; 0.05).Conclusion: Gender differences in the relationship between hamstring tightness and trunk flexion flexibility are significant. However, there was no significant difference between males and females in the relationship between hamstring tightness and lumbar lordosis