Quantum Distinguishing Attacks against Type-1 Generalized Feistel Ciphers

A generalized Feistel cipher is one of the methods to construct block ciphers, and it has several variants. Dong, Li, and Wang showed quantum distinguishing attacks against the $(2d-1)$-round Type-1 generalized Feistel cipher with quantum chosen-plaintext attacks, where $d\ge 3$, and they also showed key recovery attacks [Dong, Li, Wang. Sci China Inf Sci, 2019, 62(2): 022501]. In this paper, we show a polynomial time quantum distinguishing attack against the $(3d-3)$-round version, i.e., we improve the number of rounds by $(d-2)$. We also show a quantum distinguishing attack against the $(d^2-d+1)$-round version in the quantum chosen-ciphertext setting. We apply these quantum distinguishing attacks to obtain key recovery attacks against Type-1 generalized Feistel ciphers

Structural basis of L-glucose oxidation by scyllo-inositol dehydrogenase: Implications for a novel enzyme subfamily classification

For about 70 years, L-glucose had been considered non-metabolizable by either mammalian or bacterial cells. Recently, however, an L-glucose catabolic pathway has been discovered in Paracoccus laeviglucosivorans, and the genes responsible cloned. Scyllo-inositol dehydrogenase is involved in the first step in the pathway that oxidizes L-glucose to produce L-glucono-1,5-lactone with concomitant reduction of NAD+ dependent manner. Here, we report the crystal structure of the ternary complex of scyllo-inositol dehydrogenase with NAD+ and L-glucono-1,5-lactone at 1.8 Å resolution. The enzyme adopts a homo-tetrameric structure, similar to those of the inositol dehydrogenase family, and the electron densities of the bound sugar was clearly observed, allowing identification of the residues responsible for interaction with the substrate in the catalytic site. In addition to the conserved catalytic residues (Lys106, Asp191, and His195), another residue, His318, located in the loop region of the adjacent subunit, is involved in substrate recognition. Site-directed mutagenesis confirmed the role of these residues in catalytic activity. We also report the complex structures of the enzyme with myo-inositol and scyllo-inosose. The Arg178 residue located in the flexible loop at the entrance of the catalytic site is also involved in substrate recognition, and plays an important role in accepting both L-glucose and inositols as substrates. On the basis of these structural features, which have not been identified in the known inositol dehydrogenases, and a phylogenetic analysis of IDH family enzymes, we suggest a novel subfamily of the GFO/IDH/MocA family. Since many enzymes in this family have not biochemically characterized, our results could promote to find their activities with various substrates

Melting of excitonic insulator phase by an intense terahertz pulse in Ta2_2NiSe5_5

In this study, the optical response to a terahertz pulse was investigated in the transition metal chalcogenide Ta$_2$NiSe$_5$, a candidate excitonic insulator. First, by irradiating a terahertz pulse with a relatively weak electric field (0.3 MV/cm), the spectral changes in reflectivity near the absorption edge due to third-order optical nonlinearity were measured and the absorption peak characteristic of the excitonic phase just below the interband transition was identified. Next, by irradiating a strong terahertz pulse with a strong electric field of 1.65 MV/cm, the absorption of the excitonic phase was found to be reduced, and a Drude-like response appeared in the mid-infrared region. These responses can be interpreted as carrier generation by exciton dissociation induced by the electric field, resulting in the partial melting of the excitonic phase and metallization. The presence of a distinct threshold electric field for carrier generation indicates exciton dissociation via quantum-tunnelling processes. The spectral change due to metallization by the electric field is significantly different from that due to the strong optical excitation across the gap, which can be explained by the different melting mechanisms of the excitonic phase in the two types of excitations.Comment: 66 pages, 11 figures, 2 table

Constraints on the Intracluster Dust Emission in the Coma Cluster of Galaxies

We have undertaken a search for the infrared emission from the intracluster dust in the Coma cluster of galaxies by the Multiband Imaging Photometer for Spitzer. Our observations yield the deepest mid and far-infrared images of a galaxy cluster ever achieved. In each of the three bands, we have not detected a signature of the central excess component in contrast to the previous report on the detection by Infrared Space Observatory (ISO). We still find that the brightness ratio between 70 and 160 microns shows a marginal sign of the central excess, in qualitative agreement with the ISO result. Our analysis suggests that the excess ratio is more likely due to faint infrared sources lying on fluctuating cirrus foreground. Our observations yield the 2 sigma upper limits on the excess emission within 100 kpc of the cluster center as 5 x 10^-3 MJy/sr, 6 x 10^-2 MJy/sr, and 7 x 10^-2 MJy/sr, at 24, 70, and 160 microns, respectively. These values are in agreement with those found in other galaxy clusters and suggest that dust is deficient near the cluster center by more than 3 orders of magnitude compared to the interstellar medium.Comment: 10 pages, 9 figures, minor changes to match version published in Ap

大型核融合試験施設におけるメガワットミリ波ジャイロトロン発振器周辺の電磁環境調査

将来のエネルギー源として開発が進められている磁場閉じ込め方式の核融合研究では，高温プラズマの生成や制御，プラズマ加熱及び計測のために大電力高周波発振機器が利用されている．本論文では，核融合科学研究所の大型ヘリカル装置で使用されているメガワットミリ波ジャイロトロン発振器(周波数: 77 GHz，最大出力: 1～1.5 MW/2秒)を対象とし，作業従事者の安全管理を目的に，ホーンアンテナを用いて機器周辺での電磁環境を定点調査した．その結果，77 GHz発振器からおよそ30 m離れた場所で観測された漏洩電界の周波数は，77 GHzが最も強く，そこから数GHz離れた両側の周波数領域にも微弱なスプリアススペクトルが確認された．また，同じ場所で，数十秒から数百秒の発振運転に伴う漏洩電界(最大実効値: 数V/m)が観測された．電界の漏洩箇所は，ジャイロトロン発振器を構成する接地電位の電子ビームコレクターと，その他の部位とを電気的に絶縁するために具備された窒化ケイ素製絶縁部と推定された．本研究により，大型核融合試験施設におけるメガワットジャイロトロン発振器周辺のミリ波帯での漏洩電界の実態を初めて明らかにした

Noninvasive assessment of the cardiac baroreflex Response to downward tilting and comparison with the phenylephrine method

AbstractOBJECTIVESWe studied the relation between changes in systolic blood pressure and RR interval during downward tilting in comparison with assessment of baroreflex sensitivity (BRS) measured by the phenylephrine method (Phe-BRS) and with measures of heart rate variability (HRV).BACKGROUNDThe method most extensively used for assessing BRS involves bolus injections of phenylephrine. Several noninvasive methods proposed to assess BRS have not been widely applied in the clinical setting.METHODSSixteen healthy male volunteers were studied (mean age ± SD 27.5 ± 4.6 years). Arterial blood pressure using tonometry and electrocardiogram was simultaneously recorded. After 20 min of 70° upright tilting, the table was returned to supine position at a speed of 3.2°/s. Subsequently, BRS was assessed using an intravenous bolus injection of phenylephrine (2 to 3 μg/kg). Heart rate variability under resting conditions also was analyzed.RESULTSIn all subjects, a beat to beat systolic blood pressure increase associated with corresponding RR interval lengthening was observed during downward tilting as well as during phenylephrine administration. During both testing procedures, these two variables showed linear correlation, and the slope of regression line during downward tilting (DT-BRS) correlated significantly with Phe-BRS (r = 0.79, p = 0.0003). The DT- and Phe-BRS also correlated significantly with the high frequency component of resting HRV (r = 0.70, p = 0.0023 for DT-BRS; r = 0.58, p = 0.0185 for Phe-BRS).CONCLUSIONSWe conclude that in a small homogeneous group DT-BRS provided an assessment of reflex cardiac vagal function comparable to that obtained by the phenylephrine method

A simplified PCR assay for fast and easy mycoplasma mastitis screening in dairy cattle

A simplified polymerase chain reaction (PCR) assay was developed for fast and easy screening of mycoplasma mastitis in dairy cattle. Species of major mycoplasma strains [Mycoplasma (M.) bovis, M. arginini, M. bovigenitalium, M. californicum, M. bovirhinis, M. alkalescens and M. canadense] in cultured milk samples were detected by this simplified PCR-based method as well as a standard PCR technique. The minimum concentration limit for detecting mycoplasma by the simplified PCR was estimated to be about 2.5 × 103 cfu/mL and was similar to that of the standard PCR. We compared the specificity and sensitivity of the simplified PCR to those of a culture method. Out of 1,685 milk samples cultured in mycoplasma broth, the simplified PCR detected Mycoplasma DNA in 152 that were also positive according to the culture assay. The sensitivity and specificity of the simplified PCR were 98.7% and 99.7%, respectively, for detecting mycoplasma in those cultures. The results obtained by the simplified PCR were consistent with ones from standard PCR. This newly developed simplified PCR, which does not require DNA purification, can analyze about 300 cultured samples within 3 h. The results from our study suggest that the simplified PCR can be used for mycoplasma mastitis screening in large-scale dairy farms

Key Committing Security of AEZ and More

For an Authenticated Encryption with Associated Data (AEAD) scheme, the key committing security refers to the security notion of whether the adversary can produce a pair of distinct input tuples, including the key, that result in the same output. While the key committing security of various nonce-based AEAD schemes is known, the security analysis of Robust AE (RAE) is largely unexplored. In particular, we are interested in the key committing security of AEAD schemes built on the Encode-then-Encipher (EtE) approach from a wide block cipher. We first consider AEZ v5, the classical and the first dedicated RAE that employs the EtE approach. We focus our analysis on the core part of AEZ to show our best attacks depending on the length of the ciphertext expansion. In the general case where the Tweakable Block Cipher (TBC) is assumed to be ideal, we show a birthday attack and a matching provable security result. AEZ adopts a simpler key schedule and the prove-then-prune approach in the full specification, and we show a practical attack against it by exploiting the simplicity of the key schedule. The complexity is 227, and we experimentally verify the correctness with a concrete example. We also cover two AEAD schemes based on EtE. One is built on Adiantum, and the other one is built on HCTR2, which are two wide block ciphers that are used in real applications. We present key committing attacks against these schemes when used in EtE and matching proofs for particular cases

A Signaling Pathway Involving TGF-β2 and Snail in Hair Follicle Morphogenesis

In a common theme of organogenesis, certain cells within a multipotent epithelial sheet exchange signals with their neighbors and develop into a bud structure. Using hair bud morphogenesis as a paradigm, we employed mutant mouse models and cultured keratinocytes to dissect the contributions of multiple extracellular cues in orchestrating adhesion dynamics and proliferation to shape the cluster of cells involved. We found that transforming growth factor β2 signaling is necessary to transiently induce the transcription factor Snail and activate the Ras-mitogen-activated protein kinase (MAPK) pathway in the bud. In the epidermis, Snail misexpression leads to hyperproliferation and a reduction in intercellular adhesion. When E-cadherin is transcriptionally down-regulated, associated adhesion proteins with dual functions in signaling are released from cell-cell contacts, a process which we demonstrate leads to Ras-MAPK activation. These studies provide insights into how multipotent cells within a sheet are stimulated to undergo transcriptional changes that result in proliferation, junctional remodeling, and bud formation. This novel signaling pathway further weaves together the web of different morphogens and downstream transcriptional events that guide hair bud formation within the developing skin