12 research outputs found
TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries
Propofol Causes Vasodilation In Vivo via TRPA1 Ion Channels: Role of Nitric Oxide and BKCa Channels
Allisartan ameliorates vascular remodeling through regulation of voltage-gated potassium channels in hypertensive rats
The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus
Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction
Dissecting out the Complex Ca2+-Mediated Phenylephrine-Induced Contractions of Mouse Aortic Segments
Contribution of electromechanical coupling between KV and CaV1.2 channels to coronary dysfunction in obesity
Contribution of voltage-dependent K+ and Ca2+ channels to coronary pressure-flow autoregulation
The hypertensive potential of estrogen: An untold story
Cardiovascular disease (CVD) is the major cause of morbidity and mortality worldwide. The implication of estrogen in this disease has been extensively studied. While the vast majority of published research argue for a cardioprotective role of estrogen in vascular inflammation such as in atherosclerosis, the role of estrogen in hypertension remains far from being resolved. The vasorelaxant effect of estrogen has already been well-established. However, emerging evidence supports a vasoconstrictive potential of this hormone. It has been proposed that the microenvironment dictates the effect of estrogen-induced type 1 nitric oxide synthase-1 (nNOS) on vasotone. Indeed, depending on nNOS product, nitric oxide or superoxide, estrogen can induce vasodilation or vasoconstriction, respectively. In this review, we discuss the evidence supporting the vasorelaxant effects of estrogen, and the molecular players involved. Furthermore, we shed light on recent reports revealing a vasoconstrictive role of estrogen, and speculate on the underlying signaling pathways. In addition, we identify certain factors that can account for the discrepant estrogenic effects. This review emphasizes a yin-yang role of estrogen in regulating blood pressure. 2019This publication was made possible by an MPP Fund (#320133) from the American University of Beirut-Faculty of Medicine to Ali Eid and The National Center for Scientific Research (CNRS) to Manal Fardoun.Scopu