Antioxidant activity of Piper caninum and Cyclooxygenase-2 inhibition by methoxylated flavones.

Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones.Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively.Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations.Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrationsKey words: Piper caninum; antioxidant; cyclooxygenase-2.List of abbreviations: COX-2, cyclooxygenase-2; DPPH, 2,2-diphenyl- 1-picrylhydrazyl; PGE2, prostaglandin E2

PENGARUH STRES KERJA DAN BEBAN KERJA TERHADAP KINERJA KARYAWAN DI PT. INSAN SANDANG INTERNUSA PADA DIVISI WEAVING KABUPATEN SUMEDANG

ABSTRAK Penelitian ini dilakukan untuk menguji pengaruh Stres kerja dan Beban Kerja terjadap Kinerja Karyawan di PT. Insan Sandang Internusa pada Divisi Weaving Kabupaten Sumedang baik secara parsial maupun simultan. Populasi dalam penelitian ini yaitu 140 orang dan jumlah sampel sebanyak 58 orang Responden. Penelitian ini menggunakan pendekatan kuantitatif, analisis data yang digunakan yaitu metode analisis linier berganda, analisis korelasi berganda, analisis koefisien determinasi. Hasil dari penelitian ini menunjukkan bahwa Stres Kerja memiliki pengaruh signifikan terhadap Kinerja Karyawan sebesar 31,2% dan Beban memiliki pengaruh signifikan sebesar 21,3%. Variabel yang paling mempengaruhi keputusan pembelian yaitu Stres Kerja. Stres Kerja dan Beban Kerja memiliki pengaruh signifikan terhadap Kinerja Karyawan sebesar 52,5% sedangkan sisanya sebesar 47,5% dipengaruhi oleh faktor-faktor lain yang tidak diteliti. Kata kunci : Stres Kerja, Beban Kerja dan Kinerja Karyawan

PENGARUH ETOS KERJA, INSENTIF DAN PENGEMBANGAN KARIR TERHADAP KINERJA PEGAWAI DI LINGKUNGAN SEKRETARIAT DEWAN PERWAKILAN RAKYAT DAERAH PROVINSI JAWA BARAT

ABSTRAK Peningkatan kinerja pegawai akan membawa kemajuan bagi instansi untuk dapat bertahan dalam suatu instansi karena kinerja dapat mencerminkan peningkatan dari waktu ke waktu dalam bekerja. Oleh karena itu upaya-upaya untuk meningkatkan kinerja pegawai merupakan tantangan manajemen yang paling penting karena keberhasilan untuk mencapai tujuan dan kelangsungan hidup instansi tergantung pada kualitas kinerja sumber daya manusia yang ada didalamnya. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh etos kerja, insentif dan pengembangan karir terhadap kinerja pegawai. penelitian ini dilakukan di Lingkungan Sekretariat Dewan Perwakilan Rakyat Daerah Provinsi Jawa Barat. Metode penelitian yang digunakan adalah deskriptif dan verifikatif. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan menyebarkan kuesioner kepada 60 responden. Metode analisis yang digunakan adalah analisis regresi linier berganda, analisis kolerasi berganda dan analisis koefisien determinasi. Hasil penelitian ini menunjukan bahwa adanya pengaruh etos kerja, insentif dan pengembangan karir berpengaruh positif dan signifikan terhadap kinerja pegawai. Etos kerja, insentif dan pengembanygan karir memberikan pengaruh terhadap kinerja sebesar 86,74%, pengaruh variabel independen yang dominan adalah pengembangan karir sebesar 79,42%, pengaruh insentif sebesar 5,7% sedangkan etos kerja sebesar 1,62%. Kata Kunci : Etos Kerja, Insentif, Pengembangan Karir Dan Kinerja Pegawa

PENGARUH INDEPENDENSI, KOMPETENSI, DAN DUE PROFESSIONAL CARE TERHADAP KUALITAS AUDIT (Survey pada 10 Kantor Akuntan Publik di Kota Bandung)

ABSTRAK Penelitian ini bertujuan untuk mengetahui besarnya pengaruh Independensi, Kompetensi, dan Due Professional Care terhadap Kualitas Audit pada 10 Kantor Akuntan Publik di Kota Bandung. Pendekatan penelitian yang digunakan dalam penelitian ini adalah analisis deskriptif dan verifikatif dengan menggunakan data primer. Teknik sampling yang digunakan adalah non probability sampling dengan menggunakan data primer. Analisis statistik yang digunakan dalam penelitian ini adalah uji asumsi klasik, analisis regresi, korelasi, pengujian hipotesis dengan menggunakan uji t dan uji f serta analisis koefisien determinasi. Banyaknya populasi penelitian adalah 109 auditor dari 10 Kantor Akuntan Publik di Kota Bandung yang diambil sampelnya sebanyak 86 auditor dengan sumber data yang diperoleh melalui hasil pengisian kuesioner. Berdasarkan hasil penelitian yang dilakukan dapat diketahui bahwa secara parsial besarnya variabel Independensi berpengaruh sebsar 15,6%, Kompetensi sebesar 27,1%, dan Due Professional Care sebesar 19,5% terhadap Kualitas Audit. Besarnya pengaruh secara simultan variabel Independensi, Kompetensi, dan Due Professional Care terhadap Kualitas Audit sebesar 62,4%, sedangkan sisanya sebesar 37,6% merupakan faktor lain diluar ketiga variabel independen yang diteliti, seperti faktor akuntabilitas, pengalaman kerja, obyektifitas, integritas, dan lain-lain. Kata Kunci: Indepenpendsi, Kompetensi, dan Due Professional Care terhadap Kualitas Audi

Approaches in biotechnological applications of natural polymers

Natural polymers, such as gums and mucilage, are biocompatible, cheap, easily available and non-toxic materials of native origin. These polymers are increasingly preferred over synthetic materials for industrial applications due to their intrinsic properties, as well as they are considered alternative sources of raw materials since they present characteristics of sustainability, biodegradability and biosafety. As definition, gums and mucilages are polysaccharides or complex carbohydrates consisting of one or more monosaccharides or their derivatives linked in bewildering variety of linkages and structures. Natural gums are considered polysaccharides naturally occurring in varieties of plant seeds and exudates, tree or shrub exudates, seaweed extracts, fungi, bacteria, and animal sources. Water-soluble gums, also known as hydrocolloids, are considered exudates and are pathological products; therefore, they do not form a part of cell wall. On the other hand, mucilages are part of cell and physiological products. It is important to highlight that gums represent the largest amounts of polymer materials derived from plants. Gums have enormously large and broad applications in both food and non-food industries, being commonly used as thickening, binding, emulsifying, suspending, stabilizing agents and matrices for drug release in pharmaceutical and cosmetic industries. In the food industry, their gelling properties and the ability to mold edible films and coatings are extensively studied. The use of gums depends on the intrinsic properties that they provide, often at costs below those of synthetic polymers. For upgrading the value of gums, they are being processed into various forms, including the most recent nanomaterials, for various biotechnological applications. Thus, the main natural polymers including galactomannans, cellulose, chitin, agar, carrageenan, alginate, cashew gum, pectin and starch, in addition to the current researches about them are reviewed in this article.. }To the Conselho Nacional de Desenvolvimento Cientfíico e Tecnológico (CNPq) for fellowships (LCBBC and MGCC) and the Coordenação de Aperfeiçoamento de Pessoal de Nvíel Superior (CAPES) (PBSA). This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit, the Project RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and COMPETE 2020 (POCI-01-0145-FEDER-006684) (JAT)

Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications

Arunpandian Balaji, Saravana Kumar Jaganathan, Eko Supriyanto, Ida Idayu Muhamad, Ahmad Zahran Md Khudzari Institut Jantung Negara-Universiti Teknologi Malaysia, Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia Abstract: Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera, a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera-induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera-glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants. Keywords: Metallocene polyethylene, fibrous coating, physicochemical properties, blood compatibilit