Decoupling between precipitation processes and mountain wave induced circulations observed with a vertically pointing K-Band Doppler radar

Recent studies reported that precipitation and mountain waves induced low tropospheric level circulations may be decoupled or masked by greater spatial scale variability despite generally there is a connection between microphysical processes of precipitation and mountain driven air flows. In this paper we analyse two periods of a winter storm in the Eastern Pyrenees mountain range (NE Spain) with different mountain wave induced circulations and low-level turbulence as revealed by Micro Rain Radar (MRR), microwave radiometer and Parsivel disdrometer data during the Cerdanya-2017 field campaign. We find that during the event studied mountain wave wind circulations and low-level turbulence do not affect neither the snow crystal riming or aggregation along the vertical column nor the surface particle size distribution of the snow. This study illustrates that precipitation profiles and mountain induced circulations may be decoupled which can be very relevant for either ground-based or spaceborne remote sensing of precipitation

The Avalanche of Les Fonts d'Arinsal (Andorra): An Example of a Pure Powder, Dry Snow Avalanche

On 8th February 1996, in the north-western part of Andorra in the Pyrenees, the Les Fonts d'Arinsal (LFd'A) pure powder avalanche was triggered, descending some 1200 m to the bottom of the Arinsal valley and continuing up the opposite slope for about 200 m. This size 4-5 avalanche reached velocities of up to 80 ms−1, devastated 18 ha of forest, involved a minimum volume of up to 1.8 × 106 m−3 and caused major damage to eight buildings. Fortunately, no one was injured thanks to an evacuation, but 322 people lost their properties. This study describes the physical characteristics of the LFd'A avalanche path and provides data on earlier avalanches, the meteorological synoptic situation and snowpack conditions that generated the avalanche episode, the warning and preventive actions carried out, the effects and evidence of the large avalanche, and the defence system implemented afterwards. A discussion of the avalanche dynamics based on observations and damage, including the role of snow entrainment, the total lack of characteristic dense flow deposits, as well as the evidence of a two-phase flow (fluidisation and suspension), is presented. This case study is an example of a paradigmatic large, pure powder, dry-snow avalanche, which will be useful for model calibration

Elucidating the Effect of Nutritional Imbalances of N and K on the Infection of Verticillium dahliae in Olive

The effect of mineral nutrition on wilt diseases has been previously reported in many herbaceous hosts, though such an effect on Verticillium wilt in olive (Olea europaea L.; VWO), caused by Verticillium dahliae, is still uncertain. Field observations reveal that nitrogen (N) excess or imbalances of N-potassium (K) favour VWO epidemics. However, this has yet to be demonstrated. Thus, the aim of this study was to evaluate the influences of nutritional imbalances of N and K in V. dahliae infection of olive. To this end, adjusted treatments with N excess (↑N+↑Na), K deficiency (↓K) and their combination (↑N+↑Na+↓K) were evaluated on the viability of V. dahliae microsclerotia (MS), as well as on disease development in olive plants. In parallel, the potential indirect effect of the treatments on the viability of conidia and MS of V. dahliae was evaluated through the stimuli of root exudates. Treatments ↑N+↑Na and ↑N+↑Na+↓K decreased MS germination and disease progress, whereas ↓K significantly increased both parameters. Root exudates from treated plants increased the conidia germination of V. dahliae but reduced the MS germination. The results of this study will be the basis for planning further research towards a better understanding of the effect of mineral nutrition on VWO

Vertical structure and microphysical observations of winter precipitation in an inner valley during the Cerdanya-2017 field campaign

Precipitation processes at windward and leeward sides of the mountains have been object of study for many decades. Instead, inner mountain valleys, where usually most mountain population lives, have received considerably less attention. This article examines precipitation processes during a winter field campaign in an inner valley of the Pyrenees (NE Spain) using, among other instruments, a K-band vertically pointing Doppler radar (Micro Rain Radar) and a laser-based optical disdrometer (Parsivel). A decoupling is found between the stalled air of the valley and the air of the free atmosphere above the mountain crest level, evidenced by an increase of turbulence and spectral width of precipitation particles. Wind shear layer may promote riming and aggregation of the ice and snow particles. Two main rainfall regimes are found during the campaign: (1) stratiform rainfall mostly produced by water vapour deposition processes, although sometimes riming and aggregation become important, and (2) weak convection with slight dominance of collision-coalescence processes. Precipitation characteristics at the bottom of the valley show typical continental features such as low Liquid Water Content, despite the valley is only about 100 km from the sea. This study demonstrates that inner valley may present distinct precipitation features with respect to windward and leeward precipitation

Un análisis econométrico de la relación de sustitución entre el AVE y el transporte aéreo

La implantación del AVE en España se ha convertido en un ejemplo a nivel mundial, pero conlleva grandes costes, además de competir con las líneas aéreas ya existentes, y con las nuevas LCC que han surgido durante este periodo. Es este trabajo analizamos desde una perspectiva dinámica la relación de sustitución que existe entre estos dos medios de transporte, observando una relación mucho menos estrecha que la prevista en estudios realizados a priori

Characterisation of Extreme Precipitation Events in the Pyrenees: From the Local to the Synoptic Scale

Mountain systems within the Mediterranean region, e.g., the Pyrenees, are very sensitive to climate change. In the present study, we quantified the magnitude of extreme precipitation events and the number of days with torrential precipitation (daily precipitation ≥ 100 mm) in all the rain gauges available in the Pyrenees for the 1981-2015 period, analyzing the contribution of the synoptic scale in this type of event. The easternmost (under Mediterranean influence) and north-westernmost (under Atlantic influence) areas of the Pyrenees registered the highest number of torrential events. The heaviest events are expected in the eastern part, i.e., 400 mm day−1 for a return period of 200 years. Northerly advections over the Iberian Peninsula, which present a low zonal index, i.e., implying a stronger meridional component, give rise to torrential events over the western Pyrenees; and easterly advections favour extreme precipitation over the eastern Pyrenees. The air mass travels a long way, from the east coast of North America, bringing heavy rainfall to the western Pyrenees. In the case of the torrential events over the eastern Pyrenees, the trajectory of the air mass causing the events in these areas is very short and originates in the Mediterranean Basin. The North Atlantic Oscillation (NAO) index has no influence upon the occurrence of torrential events in the Pyrenees, but these events are closely related to certain Mediterranean teleconnections such as the Western Mediterranean Oscillation (WeMO)

Impaired expression of ectonucleotidases in ectopic and eutopic endometrial tissue is in favor of ATP accumulation in the tissue microenvironment in endometriosis

Endometriosis is a prevalent disease defined by the presence of endometrial tissue outside the uterus. Adenosine triphosphate (ATP), as a proinflammatory molecule, promotes and helps maintain the inflammatory state of endometriosis. Moreover, ATP has a direct influence on the two main symptoms of endometriosis: infertility and pain. Purinergic signaling, the group of biological responses to extracellular nucleotides such as ATP and nucleosides such as adenosine, is involved in the biology of reproduction and is impaired in pathologies with an inflammatory component such as endometriosis. We have previously demonstrated that ectonucleotidases, the enzymes regulating extracellular ATP levels, are active in non-pathological endometria, with hormone-dependent changes in expression throughout the cycle. In the present study we have focused on the expression of ectonucleotidases by means of immunohistochemistry and in situ activity in eutopic and ectopic endometrial tissue of women with endometriosis, and we compared the results with endometria of women without the disease. We have demonstrated that the axis CD39-CD73 is altered in endometriosis, with loss of CD39 and CD73 expression in deep infiltrating endometriosis, the most severe, and most recurring, endometriosis subtype. Our results indicate that this altered expression of ectonucleotidases in endometriosis boosts ATP accumulation in the tissue microenvironment. An important finding is the identification of the nucleotide pyrophophatase/phosphodiesterase 3 (NPP3) as a new histopathological marker of the disease since we have demonstrated its expression in the stroma only in endometriosis, in both eutopic and ectopic tissue. Therefore, targeting the proteins directly involved in ATP breakdown could be an appropriate approach to consider in the treatment of endometriosis

XDM-Compatible Service Repository for User-Centric Service Creation and Discovery

The key objective of OPUCE system is to enable the participation of end-users in the management of their own services, by providing them with innovative tools which allow an easy creation and delivery of personalized communication and information services. This paper describes the OPUCE service and component repository, which extends the OMA OSPE service model storage approach XDM. By integrating an ebXML registry using the native notification mechanisms of XDM, the search capability of the repository is dramatically improved. Moreover, this repository also exploits semantic Web technology to provide an intuitive visualized browser for convenient service exploring

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. mGluRs can form both constitutive homo- and heterodimers. Whereas both mGlu2 and mGlu4 couple to G proteins, G protein activation is mediated by mGlu4 heptahelical domain (HD) exclusively in mGlu2-4 heterodimers. Such asymmetric transduction results from the action of both the dimeric extracellular domain, and an allosteric activation by the partially-activated non-functional mGlu2 HD. G proteins activation by mGlu2 HD occurs if either the mGlu2 HD is occupied by a positive allosteric modulator or if mGlu4 HD is inhibited by a negative modulator. These data revealed an oriented asymmetry in mGlu heterodimers that can be controlled with allosteric modulators. They provide new insight on the allosteric interaction between subunits in a GPCR dimer

Study protocol of cost-effectiveness and cost-utility of a biopsychosocial multidisciplinary intervention in the evolution of non-specific sub-acute low back pain in the working population: cluster randomised trial.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background: Low back pain (LBP), with high incidence and prevalence rate, is one of the most common reasons to consult the health system and is responsible for a significant amount of sick leave, leading to high health and social costs. The objective of the study is to assess the cost-effectiveness and cost-utility analysis of a multidisciplinary biopsychosocial educational group intervention (MBEGI) of non-specific sub-acute LBP in comparison with the usual care in the working population recruited in primary healthcare centres. Methods/design: The study design is a cost-effectiveness and cost-utility analysis of a MBEGI in comparison with the usual care of non-specific sub-acute LBP.Measures on effectiveness and costs of both interventions will be obtained from a cluster randomised controlled clinical trial carried out in 38 Catalan primary health care centres, enrolling 932 patients between 18 and 65 years old with a diagnosis of non-specific sub-acute LBP. Effectiveness measures are: pharmaceutical treatments, work sick leave (% and duration in days), Roland Morris disability, McGill pain intensity, Fear Avoidance Beliefs (FAB) and Golberg Questionnaires. Utility measures will be calculated from the SF-12. The analysis will be performed from a social perspective. The temporal horizon is at 3 months (change to chronic LBP) and 12 months (evaluate the outcomes at long term. Assessment of outcomes will be blinded and will follow the intention-to-treat principle. Discussion: We hope to demonstrate the cost-effectiveness and cost-utility of MBEGI, see an improvement in the patients' quality of life, achieve a reduction in the duration of episodes and the chronicity of non-specific low back pain, and be able to report a decrease in the social costs. If the intervention is cost-effectiveness and cost-utility, it could be applied to Primary Health Care Centres. Trial registration: ISRCTN: ISRCTN5871969