2,737 research outputs found
Matrix Product States: Symmetries and Two-Body Hamiltonians
We characterize the conditions under which a translationally invariant matrix
product state (MPS) is invariant under local transformations. This allows us to
relate the symmetry group of a given state to the symmetry group of a simple
tensor. We exploit this result in order to prove and extend a version of the
Lieb-Schultz-Mattis theorem, one of the basic results in many-body physics, in
the context of MPS. We illustrate the results with an exhaustive search of
SU(2)--invariant two-body Hamiltonians which have such MPS as exact ground
states or excitations.Comment: PDFLatex, 12 pages and 6 figure
Single-molecule electrical contacts on silicon electrodes under ambient conditions
The ultimate goal in molecular electronics is to use individual molecules as the active electronic component of a real-world sturdy device. For this concept to become reality, it will require the field of single-molecule electronics to shift towards the semiconducting platform of the current microelectronics industry. Here, we report silicon-based single-molecule contacts that are mechanically and electrically stable under ambient conditions. The single-molecule contacts are prepared on silicon electrodes using the scanning tunnelling microscopy break-junction approach using a top metallic probe. The molecular wires show remarkable current–voltage reproducibility, as compared to an open silicon/nano-gap/metal junction, with current rectification ratios exceeding 4,000 when a low-doped silicon is used. The extension of the single-molecule junction approach to a silicon substrate contributes to the next level of miniaturization of electronic components and it is anticipated it will pave the way to a new class of robust single-molecule circuits
Historical earthquake parameters by geological and seismic site analysis: the 1908 Cerbon earthquake (Spain)
Seismic catalogues summarize information mainly on recent earthquakes and seismic events, recorded by means of relatively new instruments. Hence, this information, although being of high quality and quantitative value, sometimes is rather incomplete, since historical earthquakes are neglected in many cases. An example is the 1908 CerbĂłn earthquake (in Spain). This shake caused a good number of effects in the epicentre and surrounding area, triggering a huge landslide among some other effects. A complete geological and seismic site analysis, accompanied by a historical review of testimonies and journals of the time describing this particular earthquake, has been carried out, along with a deep field investigation to identify the mechanism of this landslide and the characteristics of the involved materials. A retrospective pseudo-static numerical simulation has been carried out to calculate the most probable range of peak horizontal accelerations during the earthquake. The results demonstrate the moderate relevance of this shake, also allowing us to quantify its objective importance. The presented methodology can be easily extended to some other similar cases, if seismic catalogues are to be completed for future designs accounting for seismic considerations
Photon Filamentation in Resonant Media with High Fresnel Numbers
The phenomenon of turbulent photon filamentation occurs in lasers and other
active optical media at high Fresnel numbers. A description of this phenomenon
is suggested. The solutions to evolution equations are presented in the form of
a bunch of filaments chaotically distributed in space and having different
radii. The probability distribution of patterns is defined characterizing the
probabilistic weight of different filaments. The most probable filament radius
and filament number are found, being in good agreement with experiment.Comment: Revtex file, 5 pages. Reference to the English edition of the journal
is give
Quantum kinetic Ising models
We introduce a quantum generalization of classical kinetic Ising models,
described by a certain class of quantum many body master equations. Similarly
to kinetic Ising models with detailed balance that are equivalent to certain
Hamiltonian systems, our models reduce to a set of Hamiltonian systems
determining the dynamics of the elements of the many body density matrix. The
ground states of these Hamiltonians are well described by matrix product, or
pair entangled projected states. We discuss critical properties of such
Hamiltonians, as well as entanglement properties of their low energy states.Comment: 20 pages, 4 figures, minor improvements, accepted in New Journal of
Physic
Clinical subgroups in bilateral meniere disease
Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, and it depends on the duration of the disease. We have performed a two-step cluster analysis in 398 patients with bilateral MD (BMD) to identify the best predictors to define clinical subgroups with a potential different etiology to improve the phenotyping of BMD and to develop new treatments. We have defined five clinical variants in BMD. Group 1 is the most frequently found, includes 46% of patients, and is defined by metachronic hearing loss without migraine and without AD. Group 2 is found in 17% of patients, and it is defined by synchronic hearing loss without migraine or AD. Group 3, with 13% of patients, is characterized by familial MD, while group 4, that includes 12% of patients, is associated by the presence of migraine in all cases. Group 5 is found in 11% of patients and is defined by AD. This approach can be helpful in selecting patients for genetic and clinical research. However, further studies will be required to improve the phenotyping in these clinical variants for a better understanding of the diverse etiological factors contributing to BMD
Analysis of Li-ion battery degradation using self-organizing maps
This paper proposes a new methodology to identify the different degradation processes of Li-Ion battery cells. The goal of this study is to determine if different degradation factors can be separated by waveform analysis from aged cells with similar remaining capacity. In contrast to other works, the proposed method identifies the past operating conditions in the cell, regardless of the actual State of Health. The methodology is based on a data-driven approach by using a SOM (Self-organizing map), an unsupervised neural network. To verify the hypothesis a SOM has been trained with laboratory data from whole data cycles, to classify cells concerning their degradation path and according to their discharge voltage patterns. Additionally, this new methodology based on the SOM allows discriminating groups of cells with different cycling conditions (based on depth of discharge, ambient temperature and discharge current). This research line is very promising for classification of used cells, not only depending on their current static parameters (capacity, impedance), but also the battery use in their past life. This will allow making predictions of the Remaining Useful Life (RUL) of a battery with greater precision
Folding of dimeric methionine adenosyltransferase III: identification of two folding intermediates
Methionine adenosyl transferase (MAT) is an essential enzyme that synthesizes AdoMet. The liver-specific MAT isoform, MAT III, is a homodimer of a 43.7-kDa subunit that organizes in three nonsequential alpha-beta domains. Although MAT III structure has been recently resolved, little is known about its folding mechanism. Equilibrium unfolding and refolding of MAT III, and the monomeric mutant R265H, have been monitored using different physical parameters. Tryptophanyl fluorescence showed a three-state folding mechanism. The first unfolding step was a folding/association process as indicated by its dependence on protein concentration. The monomeric folding intermediate produced was the predominant species between 1.5 and 3 m urea. It had a relatively compact conformation with tryptophan residues and hydrophobic surfaces occluded from the solvent, although its N-terminal region may be very unstructured. The second unfolding step monitored the denaturation of the intermediate. Refolding of the intermediate showed first order kinetics, indicating the presence of a kinetic intermediate within the folding/association transition. Its presence was confirmed by measuring the 1,8-anilinonaphtalene-8-sulfonic acid binding in the presence of tripolyphosphate. We propose that the folding rate-limiting step is the formation of an intermediate, probably a structured monomer with exposed hydrophobic surfaces, that rapidly associates to form dimeric MAT III
Interpolating between low and high energy QCD via a 5D Yang-Mills model
We describe the Goldstone bosons of massless QCD together with an infinite
number of spin-1 mesons. The field content of the model is SU(Nf)xSU(Nf)
Yang-Mills in a compact extra-dimension. Electroweak interactions reside on one
brane. Breaking of chiral symmetry occurs due to the boundary conditions on the
other brane, away from our world, and is therefore spontaneous. Our
implementation of the holographic recipe maintains chiral symmetry explicit
throughout. For intermediate energies, we extract resonance couplings. These
satisfy sum rules due to the 5D nature of the model. These sum rules imply,
when taking the high energy limit, that perturbative QCD constraints are
satisfied. We also illustrate how the 5D model implies a definite prescription
for handling infinite sums over 4D resonances. Taking the low energy limit, we
recover the chiral expansion and the corresponding non-local order parameters.
All local order parameters are introduced separately.Comment: Corresponds to published version, with some typos correcte
Genetic and functional characterization of disease associations explains comorbidity
Understanding relationships between diseases, such as
comorbidities, has important socio-economic implications,
ranging from clinical study design to health care planning. Most
studies characterize disease comorbidity using shared genetic
origins, ignoring pathway-based commonalities between diseases.
In this study, we define the disease pathways using an
interactome-based extension of known disease-genes and introduce
several measures of functional overlap. The analysis reveals 206
significant links among 94 diseases, giving rise to a highly
clustered disease association network. We observe that around
95% of the links in the disease network, though not identified
by genetic overlap, are discovered by functional overlap. This
disease network portraits rheumatoid arthritis, asthma,
atherosclerosis, pulmonary diseases and Crohn's disease as hubs
and thus pointing to common inflammatory processes underlying
disease pathophysiology. We identify several described
associations such as the inverse comorbidity relationship
between Alzheimer's disease and neoplasms. Furthermore, we
investigate the disruptions in protein interactions by mapping
mutations onto the domains involved in the interaction,
suggesting hypotheses on the causal link between diseases.
Finally, we provide several proof-of-principle examples in which
we model the effect of the mutation and the change of the
association strength, which could explain the observed
comorbidity between diseases caused by the same genetic
alterations
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