NCBI GEO: archive for functional genomics data sets—10 years on

A decade ago, the Gene Expression Omnibus (GEO) database was established at the National Center for Biotechnology Information (NCBI). The original objective of GEO was to serve as a public repository for high-throughput gene expression data generated mostly by microarray technology. However, the research community quickly applied microarrays to non-gene-expression studies, including examination of genome copy number variation and genome-wide profiling of DNA-binding proteins. Because the GEO database was designed with a flexible structure, it was possible to quickly adapt the repository to store these data types. More recently, as the microarray community switches to next-generation sequencing technologies, GEO has again adapted to host these data sets. Today, GEO stores over 20 000 microarray- and sequence-based functional genomics studies, and continues to handle the majority of direct high-throughput data submissions from the research community. Multiple mechanisms are provided to help users effectively search, browse, download and visualize the data at the level of individual genes or entire studies. This paper describes recent database enhancements, including new search and data representation tools, as well as a brief review of how the community uses GEO data. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/

Current status of nuclear cardiology in the Russian Federation

The article is devoted to the analysis of the current status of nuclear cardiology in the Russian Federation. The data on the number of facilities performing radionuclide investigations for the diagnosis and monitoring of the treatment of cardiovascular diseases, their staffing and equipment are given. The statistics of the conducted nuclear cardiology tests for 2018-2020 are given, as well as their methods, features and diagnostic significance are described

Development of A Modified UMAC Algorithm Based on Crypto­code Constructions

The development of computer technology has determined the vector for the expansion of services based on the Internet and “G” technologies. The main requirements for modern services in the banking sector are security and reliability. At the same time, security is considered not only as ensuring the confidentiality and integrity of transactions, but also their authenticity. However, in the post-quantum period, US NIST specialists question the durability of modern means of providing basic security services based on symmetric and asymmetric cryptography algorithms. The increase in computing resources allows attackers to use modern threats in combination. Thus, there is a need to search for new and/or modify known algorithms for generating MAC (message authentication codes). In addition, the growth of services increases the amount of information that needs to be authenticated. Among the well-known hash algorithms, the hash functions of universal hashing are distinguished, which allow initially determining the number of collisions and their uniform distribution over the entire set of hash codes. Possibilities of modifying the cascade hashing algorithm UMAC (message authentication code based on universal hashing, universal MAC) based on the use of McEliece crypto-code construction on algebrogeometric (elliptic codes (EC), modified elliptic codes (MEC) and damaged codes (DC). This approach allows preserving the uniqueness property, in contrast to the classical UMAC scheme based on a block symmetric cipher (AES). The presented algorithms for evaluating the properties of universality and strict universality of hash codes make it possible to evaluate the security of the proposed hashing constructs based on universal hash functions, taking into account the preservation of the universality propert