213 research outputs found
Coherent interactions between phonons and exciton or exciton-polariton condensates
We analyse the interaction of exciton and exciton-polariton condensates in
semiconductor microcavity with a coherent acoustic wave. An analytical solution
for the dispersion of excitations of coupled condensate-phonon system is found
in the approximation of k-independent interactions. Accounting for k-dependence
results in a stronger modification of the dispersion, and even in the
appearance of the "roton instability" region
The Outer Tracker Detector of the HERA-B Experiment Part I: Detector
The HERA-B Outer Tracker is a large system of planar drift chambers with
about 113000 read-out channels. Its inner part has been designed to be exposed
to a particle flux of up to 2.10^5 cm^-2 s^-1, thus coping with conditions
similar to those expected for future hadron collider experiments. 13
superlayers, each consisting of two individual chambers, have been assembled
and installed in the experiment. The stereo layers inside each chamber are
composed of honeycomb drift tube modules with 5 and 10 mm diameter cells.
Chamber aging is prevented by coating the cathode foils with thin layers of
copper and gold, together with a proper drift gas choice. Longitudinal wire
segmentation is used to limit the occupancy in the most irradiated detector
regions to about 20 %. The production of 978 modules was distributed among six
different laboratories and took 15 months. For all materials in the fiducial
region of the detector good compromises of stability versus thickness were
found. A closed-loop gas system supplies the Ar/CF4/CO2 gas mixture to all
chambers. The successful operation of the HERA-B Outer Tracker shows that a
large tracker can be efficiently built and safely operated under huge radiation
load at a hadron collider.Comment: 28 pages, 14 figure
The Outer Tracker Detector of the HERA-B Experiment. Part II: Front-End Electronics
The HERA-B Outer Tracker is a large detector with 112674 drift chamber
channels. It is exposed to a particle flux of up to 2x10^5/cm^2/s thus coping
with conditions similar to those expected for the LHC experiments. The
front-end readout system, based on the ASD-8 chip and a customized TDC chip, is
designed to fulfil the requirements on low noise, high sensitivity, rate
tolerance, and high integration density. The TDC system is based on an ASIC
which digitizes the time in bins of about 0.5 ns within a total of 256 bins.
The chip also comprises a pipeline to store data from 128 events which is
required for a deadtime-free trigger and data acquisition system. We report on
the development, installation, and commissioning of the front-end electronics,
including the grounding and noise suppression schemes, and discuss its
performance in the HERA-B experiment
Основные осложнения обширных резекций печени и пути их предупреждения
Results of 325 major liver resections were investigated. The common indications were malignant and benign lesions, hydatid cysts, purulent cholangitis, posttraumatic liver necrosis. The main complications after liver resections were massive intraoperative bleedings and acute postoperative liver failure. The main causes of blood loss and liver failure were discovered. The most effective means to prevent bleeding was anatomical liver resection. Lobe vascular occlusion is essential for minimal blood loss. Postoperative liver failure was strong associated with the small volume of the remnant liver and decrease in functional liver capacity. Precision selection of patients and preoperative portal vein embolisation lead to decrease the rate of liver failure (5,4%).Представлен анализ непосредственных результатов 325 обширных анатомических резекций печени, выполненных по поводу злокачественных и доброкачественных новообразований, паразитарных кистозных поражений, абсцедирующего холангита, последствий травм печени. Основными осложнениями, определяющими высокую степень операционного риска обширных резекций, являются массивные операционные кровотечения и послеоперационная печеночная недостаточность. Определены факторы риска развития кровотечений, приведены конкретные рекомендации по их профилактике, главной из которых является выполнение обширных резекций печени в анатомическом варианте, предпочтительно воротным способом. Минимальная кровопотеря отмечена при полной сосудистой изоляции удаляемой доли печени. Основными причинами развития тяжелых форм печеночно-почечной недостаточности являются недостаточный объем паренхимы, остающейся после резекции доли печени, и ее низкий функциональный резерв, обусловленный циррозом или выраженными дистрофическими изменениями паренхимы. Дифференцированный подход к отбору больных, использование дооперационной портальной венозной эмболизации позволили снизить частоту печеночной недостаточности до 5,4
Monitoring international migration flows in Europe. Towards a statistical data base combining data from different sources
The paper reviews techniques developed in demography, geography and statistics that are useful for bridging the gap between available data on international migration flows and the information required for policy making and research. The basic idea of the paper is as follows: to establish a coherent and consistent data base that contains sufficiently detailed, up-to-date and accurate information, data from several sources should be combined. That raises issues of definition and measurement, and of how to combine data from different origins properly. The issues may be tackled more easily if the statistics that are being compiled are viewed as different outcomes or manifestations of underlying stochastic processes governing migration. The link between the processes and their outcomes is described by models, the parameters of which must be estimated from the available data. That may be done within the context of socio-demographic accounting. The paper discusses the experience of the U.S. Bureau of the Census in combining migration data from several sources. It also summarizes the many efforts in Europe to establish a coherent and consistent data base on international migration.
The paper was written at IIASA. It is part of the Migration Estimation Study, which is a collaborative IIASA-University of Groningen project, funded by the Netherlands Organization for Scientific Research (NWO). The project aims at developing techniques to obtain improved estimates of international migration flows by country of origin and country of destination
Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial
IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. OBJECTIVE: To determine the effects of sPLA2inhibition with varespladib on cardiovascular outcomes. DESIGN, SETTING, AND PARTICIPANTS: A double-blind, randomized, multicenter trial at 362 academic and community hospitals in Europe, Australia, New Zealand, India, and North America of 5145 patients randomized within 96 hours of presentation of an acute coronary syndrome (ACS) to either varespladib (n = 2572) or placebo (n = 2573) with enrollment between June 1, 2010, and March 7, 2012 (study termination on March 9, 2012). INTERVENTIONS: Participants were randomized to receive varespladib (500 mg) or placebo daily for 16 weeks, in addition to atorvastatin and other established therapies. MAIN OUTCOMES AND MEASURES: The primary efficacy measurewas a composite of cardiovascular mortality, nonfatal myocardial infarction (MI), nonfatal stroke, or unstable angina with evidence of ischemia requiring hospitalization at 16 weeks. Six-month survival status was also evaluated. RESULTS: At a prespecified interim analysis, including 212 primary end point events, the independent data and safety monitoring board recommended termination of the trial for futility and possible harm. The primary end point occurred in 136 patients (6.1%) treated with varespladib compared with 109 patients (5.1%) treated with placebo (hazard ratio [HR], 1.25; 95%CI, 0.97-1.61; log-rank P = .08). Varespladib was associated with a greater risk of MI (78 [3.4%] vs 47 [2.2%]; HR, 1.66; 95%CI, 1.16-2.39; log-rank P = .005). The composite secondary end point of cardiovascular mortality, MI, and stroke was observed in 107 patients (4.6%) in the varespladib group and 79 patients (3.8%) in the placebo group (HR, 1.36; 95% CI, 1.02-1.82; P = .04). CONCLUSIONS AND RELEVANCE: In patients with recent ACS, varespladib did not reduce the risk of recurrent cardiovascular events and significantly increased the risk of MI. The sPLA2inhibition with varespladib may be harmful and is not a useful strategy to reduce adverse cardiovascular outcomes after ACS. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01130246. Copyright 2014 American Medical Association. All rights reserved
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
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