Scalable design of tailored soft pulses for coherent control

We present a scalable scheme to design optimized soft pulses and pulse sequences for coherent control of interacting quantum many-body systems. The scheme is based on the cluster expansion and the time dependent perturbation theory implemented numerically. This approach offers a dramatic advantage in numerical efficiency, and it is also more convenient than the commonly used Magnus expansion, especially when dealing with higher order terms. We illustrate the scheme by designing 2nd-order pi-pulses and a 6th-order 8-pulse refocusing sequence for a chain of qubits with nearest-neighbor couplings. We also discuss the performance of soft-pulse refocusing sequences in suppressing decoherence due to low-frequency environment.Comment: 4 pages, 2 tables. (modified first table, references added, minor text changes

Blending of nanoscale and microscale in uniform large-area sculptured thin-film architectures

The combination of large thickness ($>3$ $\mu$m), large--area uniformity (75 mm diameter), high growth rate (up to 0.4 $\mu$m/min) in assemblies of complex--shaped nanowires on lithographically defined patterns has been achieved for the first time. The nanoscale and the microscale have thus been blended together in sculptured thin films with transverse architectures. SiO$_x$ ($x\approx 2$) nanowires were grown by electron--beam evaporation onto silicon substrates both with and without photoresist lines (1--D arrays) and checkerboard (2--D arrays) patterns. Atomic self--shadowing due to oblique--angle deposition enables the nanowires to grow continuously, to change direction abruptly, and to maintain constant cross--sectional diameter. The selective growth of nanowire assemblies on the top surfaces of both 1--D and 2--D arrays can be understood and predicted using simple geometrical shadowing equations.Comment: 17 pages, 9 figure

Learning to manage public service organizations better: a scenario for teaching public administration

In the context of public value, it is argued that there is a need to adopt the learning organization philosophy to manage public service organizations better. For collaborative work with public sector managers or in management education, a fictitious scenario is presented to develop the concept of the learning organization as paradox. Faced with multiple and conflicting demands, public managers find it difficult to change organizational behavior in response to new knowledge. The scenario demonstrates how learning organization philosophy can be used to translate new knowledge into new behaviors. Key skills required for public managers to exploit the knowledge of all organizational members and confront the challenges of a contested concept, such as public value, are developed and comprise: summarizing evidence; making judgements, sharing thought processes on a contentious issue, and arriving at a consensus together. Contributions to public administration theory and practice are discussed

Polarization Effects in Reflecting Coronagraphs for White Light Applications in Astronomy

The properties of metal thin films have been largely overlooked in discussions of the technical limitations and problems that arise in the field of direct detection of exoplanets. Here, polarization properties and anisotropy properties of highly reflecting thin metal films are examined within the context of the requirements for the ultra-low scattered-light system performance of coronagraphs applied to space and ground-based high-contrast, white-light astronomy. Wavelength-dependent optical constants for highly reflecting thin metal films, taken from the literature are used to calculate the polarization-dependent transmissivity of a typical coronagraph. The effects of degraded performance on the astronomical science are examined. Suggestions are made for future work.Comment: 14 Pages, 7 Figures, Accepted to Astrophysical Journa

Tan(beta) enhanced Yukawa couplings for supersymmetric Higgs singlets at one loop

Extensions of the MSSM generically feature gauge singlet Higgs bosons. These singlet Higgs bosons have tan(beta)-enhanced Yukawa couplings to down-type quarks and leptons at the one-loop level. We present an effective Lagrangian incorporating these Yukawa couplings and use it to study their effect on singlet Higgs boson phenomenology within both the mnSSM and NMSSM. It is found that the loop-induced couplings represent an appreciable effect for the singlet pseudoscalar in particular, and may dominate its decay modes in some regions of parameter space.Comment: Submitted for the SUSY07 proceedings, 4 pages, 5 figure

The role of mutation rate variation and genetic diversity in the architecture of human disease

Background We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified. Results Consistent with our predictions we find that genes associated with Mendelian and complex disease are substantially longer than non-disease genes. However, we find that both Mendelian and complex disease genes are found in regions of the genome with relatively low mutation rates, as inferred from intron divergence between humans and chimpanzees, and they are predicted to have similar rates of non-synonymous mutation as other genes. Finally, we find that disease genes are in regions of significantly elevated genetic diversity, even when variation in the rate of mutation is controlled for. The effect is small nevertheless. Conclusions Our results suggest that gene length contributes to whether a gene is associated with disease. However, the mutation rate and the genetic architecture of the locus appear to play only a minor role in determining whether a gene is associated with disease

The Mersey Estuary : sediment geochemistry

This report describes a study of the geochemistry of the Mersey estuary carried out between April 2000 and December 2002. The study was the first in a new programme of surveys of the geochemistry of major British estuaries aimed at enhancing our knowledge and understanding of the distribution of contaminants in estuarine sediments. The report first summarises the physical setting, historical development, geology, hydrography and bathymetry of the Mersey estuary and its catchment. Details of the sampling and analytical programmes are then given followed by a discussion of the sedimentology and geochemistry. The chemistry of the water column and suspended particulate matter have not been studied, the chief concern being with the geochemistry of the surface and near-surface sediments of the Mersey estuary and an examination of their likely sources and present state of contamination

The aftermath of modernization: examining the impact of a change agenda on local government employees in the UK

The aftermath of modernization: examining the impact of a change agenda on local government employees in the U

Characterisation of baseline microbiological and host factors in an inception cohort of people with surgical wounds healing by secondary intention reveals circulating IL-6 levels as a potential predictive biomarker of healing [version 1; peer review: awaiting peer review]

Background: More than 2 million people per year are treated for surgical wounds in the UK. Over a quarter of these wounds are estimated to heal by secondary intention (from the “bottom up”) resulting in further complications and requiring increased healthcare resources. Identification of microbiological or host biomarkers that can predict healing outcomes may help to optimize the management of surgical wounds healing by secondary intention. However, the microbial and host factor heterogeneity amongst this diverse population is completely unexplored. Methods: We demonstrate feasibility of determining presence and levels of wound microbes and systemic host factors in an inception cohort of 54 people presenting with surgical wounds healing by secondary intention, who were subsequently followed-up for a period of 12-21 months. We present descriptive statistics for plasma levels of inflammatory, angiogenic cytokines and microRNAs, and we identify a range of wound colonizing microbes. We tentatively explore association with healing aiming to generate hypotheses for future research. Results: We report a potential correlation between poor healing outcomes and elevated interleukin (IL)-6 plasma levels at presentation (ρ=0.13) which requires confirmation. Conclusions: This study demonstrates the degree of biological heterogeneity amongst people with surgical wounds healing by secondary intention and proves the feasibility of embedding a biomarker discovery study in a cohort study in surgical wounds. Our results are essential for designing large biomarker discovery studies to further investigate the potential validity of circulating IL-6 or other factors as novel predictive biomarkers of healing for surgical wounds healing by secondary intention

Twist Defect in Chiral Photonic Structures

We demonstrate that twisting one part of a chiral photonic structure about its helical axis produces a single circularly polarized localized mode that gives rise to an anomalous crossover in propagation. Up to a crossover thickness, this defect results in a peak in transmission and exponential scaling of the linewidth for a circularly polarized wave with the same handedness as structure. Above the crossover, however, the linewidth saturates and the defect mode can be excited only by the oppositely polarized wave, resulting in a peak in reflection instead of transmission.Comment: 12 page