Energetic electron transport in the presence of magnetic perturbations in magnetically confined plasmas

The transport of energetic electrons is sensitive to magnetic perturbations. By using 3D numerical simulation of test particle drift orbits we show that the transport of untrapped electrons through an open region with magnetic perturbations cannot be described by a diffusive process. Based on our test particle simulations, we propose a model that leads to an exponential loss of particles.Comment: Accepted for publication in Journal of Plasma Physics (Energetic Electrons special issue

On the validity of the 5-dimensional Birkhoff theorem: The tale of an exceptional case

The 5-dimensional (5d) Birkhoff theorem gives the class of 5d vacuum space-times containing spatial hypersurfaces with cosmological symmetries. This theorem is violated by the 5d vacuum Gergely-Maartens (GM) space-time, which is not a representant of the above class, but contains the static Einstein brane as embedded hypersurface. We prove that the 5d Birkhoff theorem is still satisfied in a weaker sense: the GM space-time is related to the degenerated horizon metric of certain black-hole space-times of the allowed class. This result resembles the connection between the Bertotti-Robinson space-time and the horizon region of the extremal Reissner-Nordstrom space-time in general relativity.Comment: 13 pages; v2: title amended, to be published in Classical and Quantum Gravit

SU(3) Anderson impurity model: A numerical renormalization group approach exploiting non-Abelian symmetries

We show how the density-matrix numerical renormalization group (DM-NRG) method can be used in combination with non-Abelian symmetries such as SU(N), where the decomposition of the direct product of two irreducible representations requires the use of a so-called outer multiplicity label. We apply this scheme to the SU(3) symmetrical Anderson model, for which we analyze the finite size spectrum, determine local fermionic, spin, superconducting, and trion spectral functions, and also compute the temperature dependence of the conductance. Our calculations reveal a rich Fermi liquid structure.Comment: 18 pages, 9 figure

Kerr-Schild metrics revisited I. The ground state

The Kerr-Schild pencil of metrics g_{ab}+\La l_al_b is investigated in the generic case when it maps an arbitrary vacuum space-time with metric $g_{ab}$ to a vacuum space-time. The theorem is proved that this generic case, with the field $l$ shearing, does not contain the shear-free subclass as a smooth limit. It is shown that one of the K\'ota-Perj\'es metrics is a solution in the shearing class.Comment: 16 page

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells

For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner. Necroptosis, a type of programmed necrosis is defined as a death receptor-initiated process under caspase-compromised conditions. The process requires the kinase activity of receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3) and mixed lineage kinase domain-like protein (MLKL), as a substrate of RIPK3. The further downstream events remain elusive. We applied known inhibitors to characterize the contributing enzymes in necroptosis and their effect on cell viability and different cellular functions were detected mainly by flow cytometry. Here we report that staurosporine, the classical inducer of intrinsic apoptotic pathway can induce necroptosis under caspase-compromised conditions in U937 cell line. This process could be hampered at least partially by the RIPK1 inhibitor necrotstin-1 and by the heat shock protein 90 kDa inhibitor geldanamycin. Moreover both the staurosporine-triggered and the classical death ligand-induced necroptotic pathway can be effectively arrested by a lysosomal enzyme inhibitor CA-074-OMe and the recently discovered MLKL inhibitor necrosulfonamide. We also confirmed that the enzymatic role of poly(ADP-ribose)polymerase (PARP) is dispensable in necroptosis but it contributes to membrane disruption in secondary necrosis. In conclusion, we identified a novel way of necroptosis induction that can facilitate our understanding of the molecular mechanisms of necroptosis. Our results shed light on alternative application of staurosporine, as a possible anticancer therapeutic agent. Furthermore, we showed that the CA-074-OMe has a target in the signaling pathway leading to necroptosis. Finally, we could differentiate necroptotic and secondary necrotic processes based on participation of PARP enzyme

Active Galactic Nuclei with Starbursts: Sources for Ultra High Energy Cosmic Rays

Ultra high energy cosmic ray events presently show a spectrum, which we interpret here as galactic cosmic rays due to a starburst in the radio galaxy Cen A pushed up in energy by the shock of a relativistic jet. The knee feature and the particles with energy immediately higher in galactic cosmic rays then turn into the bulk of ultra high energy cosmic rays. This entails that all ultra high energy cosmic rays are heavy nuclei. This picture is viable if the majority of the observed ultra high energy events come from the radio galaxy Cen A, and are scattered by intergalactic magnetic fields across most of the sky.Comment: 4 pages, 1 figure, proceedings of "High-Energy Gamma-rays and Neutrinos from Extra-Galactic Sources", Heidelber