Electron beam compression with electric and magnetic fields

Electron beam compression with electrostatic and magnetostatic field

A preliminary evaluation of a new control-knob design for electronic equipment

Two experiments were carried out using five subjects to compare performance using standard and flush fitting rotary controls for electronic equipment. It vas found that the flush knob could be rotated more quickly through several revolutions, but a given setting accuracy was achieved less quickly using this flush knob. Some of the more general advantages and disadvantages of the flush knob are outlined. It should be noted that the primary objective of this study was to provide the participants with some experience in carrying out Human Factors studies and the time allowed was not such as to permit a comprehensive evaluation of the new knob design

Laminin and fibronectin in rectal adenocarcinoma: relationship to tumour grade, stage and metastasis.

Using an immunoperoxidase procedure, we have examined the distribution of laminin and fibronectin in normal human large intestinal mucosa and in 50 cases of rectal adenocarcinoma for which extensive clinical follow up was available. In normal tissue, laminin staining was largely restricted to basement membranes, including that underlying the epithelial cells, whereas fibronectin was found in both basement membranes and surrounding connective tissue. In rectal carcinomas, basement membrane-like staining for laminin associated with tumour cells was found in only 27 out of the 50 cases studied. Statistical analysis showed that the presence of laminin-containing basement membranes was correlated with low histological grade (well-differentiated tumours), but not with stage (progression through the bowel wall and the development of lymph node metastases) and, in a highly significant way, with a reduced incidence of distant metastases and increased patient survival. Although fibronectin was found in tumour cell basement membranes where these were present, it was also found in the stroma of all 50 tumours. There was no apparent correlation between the presence of stromal fibronectin and grade, stage or development of metastases. Finally, attention is drawn to some of the technical difficulties in detecting basement membrane antigens in formalin-fixed tissue, the material most frequently available for retrospective study

An electron Talbot interferometer

The Talbot effect, in which a wave imprinted with transverse periodicity reconstructs itself at regular intervals, is a diffraction phenomenon that occurs in many physical systems. Here we present the first observation of the Talbot effect for electron de Broglie waves behind a nanofabricated transmission grating. This was thought to be difficult because of Coulomb interactions between electrons and nanostructure gratings, yet we were able to map out the entire near-field interference pattern, the "Talbot carpet", behind a grating. We did this using a Talbot interferometer, in which Talbot interference fringes from one grating are moire'-filtered by a 2nd grating. This arrangement has served for optical, X-ray, and atom interferometry, but never before for electrons. Talbot interferometers are particularly sensitive to distortions of the incident wavefronts, and to illustrate this we used our Talbot interferometer to measure the wavefront curvature of a weakly focused electron beam. Here we report how this wavefront curvature demagnified the Talbot revivals, and we discuss applications for electron Talbot interferometers.Comment: 5 pages, 5 figures, updated version with abstrac

Lack of correlation between metastasis of human rectal carcinoma and the absence of stromal fibronectin.

In a retrospective study we have used an immunoperoxidase procedure to localize the glycoprotein fibronectin in human rectal carcinomas, concentrating on tumour invading thick-walled extramural veins. Fibronectin was present in 29 out of 38 cases, in connective tissue stroma, and was not in direct association with the tumour cells, except in areas of necrosis. We found no correlation between the presence or absence of stromal fibronectin and (1) the degree of cellular differentiation within the tumour, (2) tumour progression (Dukes' classification) (3) the subsequent development of metastases and (4) patient longevity. OUr results do not support the conclusions from in vitro studies (Smith et al., 1979) that the metastatic potential of carcinomas may be partly determined by the ability of tumour cells to synthesize pericellular fibronectin

On the stability of very massive primordial stars

The stability of metal-free very massive stars ($Z$ = 0; M = 120 - 500 \msol) is analyzed and compared with metal-enriched stars. Such zero-metal stars are unstable to nuclear-powered radial pulsations on the main sequence, but the growth time scale for these instabilities is much longer than for their metal-rich counterparts. Since they stabilize quickly after evolving off the ZAMS, the pulsation may not have sufficient time to drive appreciable mass loss in Z = 0 stars. For reasonable assumptions regarding the efficiency of converting pulsational energy into mass loss, we find that, even for the larger masses considered, the star may die without losing a large fraction of its mass. We find a transition between the $\epsilon$- and $\kappa$-mechanisms for pulsational instability at Z\sim 2\E{-4} - 2\E{-3}. For the most metal-rich stars, the $\kappa$-mechanism yields much shorter $e$-folding times, indicating the presence of a strong instability. We thus stress the fundamental difference of the stability and late stages of evolution between very massive stars born in the early universe and those that might be born today.Comment: 7 pages, 5 figures. Minor changes, more results given in Table 1, accepted for publication in Ap