Saúde ambiental e desenvolvimento na Amazônia legal: indicadores socioeconômicos, ambientais e sanitários, desafios e perspectivas

Resumo Este artigo tem por objetivo discutir os processos de determinação socioambiental nos estados que compõem a Amazônia Legal, com base na análise de indicadores socioeconômicos, ambientais e sani tários. Nesse sentido, os resultados demonstraram uma região dinâmica e muito heterogênea, com uma população crescente e concentrada principal mente em áreas urbanas, combinando crescimento econômico e degradação ambiental a um rápido e precário processo de urbanização e aos projetos de desenvolvimento voltados para a exploração de recursos naturais. O resultado é um quadro com plexo de problemas de saúde, com expressividade das doenças infecciosas e parasitárias relaciona das às intensas mudanças ambientais e às difíceis condições de vida, decorrentes principalmente da persistência de imensas desigualdades nos indica dores sociais e econômicos. Tais vulnerabilidades produzem efeitos negativos no quadro ambiental e sanitário da região

Data for: Group size and the (in)efficiency of pure public good provision

Abstract of associated article: Are larger groups better at cooperation than smaller groups? This paper investigates, under controlled conditions, the presence and direction of a possible group size effect in pure public good provision by large heterogeneous groups. Employing subjects drawn from the general population and introducing Internet-based procedures to study this question, we collected experimental evidence from 1110 subjects playing a linear public goods game in groups of 10, 40, and 100 members. We find a positive and significant group size effect: Increasing group size by a factor of 10 (4) increased efficiency by 10 (6) percent. The effect arose at the intensive margin and with repetition. Those who contributed contributed more in larger groups. Larger and smaller groups had similar initial contribution levels, but cooperation rates declined more slowly in the larger groups. Free-riding was invariant to group size, despite subjects׳ persistent beliefs of a negative group size effect at the extensive margin. Further econometric examination of the data supports these findings and provides starting points for future theoretical and experimental research on the group size effect

Data for: Is There No “I” in “Team”? Interindividual-Intergroup Discontinuity Effect in a Cournot Competition Experiment

Abstract of associated article: Even though firms consist of teams of individuals, industrial organization experiments are typically conducted under the unitary player assumption with individuals representing firms. Against this practice, there is evidence that individuals' decisions differ from those made by teams, and also from individuals' decisions which affect both oneself and others. This study examines the empirical scope of the unitary player assumption (alternatively the ``interindividual-intergroup discontinuity effect'') in the context of a Cournot competition experiment. In the first, standard, experiment (216 participants), we find no evidence for the discontinuity effect. Output choices of both individuals and teams are around the Cournot outcome. In a second experiment (198 participants), we use a recommendation to shift participants' initial disposition towards the (off-equilibrium) collusive output. This triggers the discontinuity effect; individuals choose lower outputs and collude more than teams. This effect is persistent in the second half of the experiment, and is not caused by team-member discussion or by seating team members together. We discuss the interpretations and implications of our results

Challenging conventional wisdom: Experimental evidence on heterogeneity and coordination in avoiding a collective catastrophic event

Avoiding a catastrophic climate change event is a global public good characterized by several dimensions, notably heterogeneity between the parties involved. It is often argued that such heterogeneity between countries is a major obstacle to cooperative climate policy. We challenge this belief by experimentally simulating two important heterogeneities, in wealth and loss, when dangerous climate change occurs. We find that under loss heterogeneity the success rate in achieving sufficient mitigation to prevent catastrophic climate change is higher than with homogeneous parties. We also observe that neither endowment heterogeneity nor the combination of endowment and loss heterogeneities lead to significantly different success rates than with homogeneous parties. Our findings suggest that heterogeneities may facilitate rather than hinder successful international climate policy negotiations

High efficiency cell-specific targeting of cytokine activity

International audienceSystemic toxicity currently prevents exploiting the huge potential of many cytokines for medical applications. Here we present a novel strategy to engineer immunocytokines with very high targeting efficacies. The method lies in the use of mutants of toxic cytokines that markedly reduce their receptor-binding affinities, and that are thus rendered essentially inactive. Upon fusion to nanobodies specifically binding to marker proteins, activity of these cytokines is selectively restored for cell populations expressing this marker. This ‘activity-bytargeting’ concept was validated for type I interferons and leptin. In the case of interferon, activity can be directed to target cells in vitro and to selected cell populations in mice, with up to 1,000-fold increased specific activity. This targeting strategy holds promise to revitalize the clinical potential of many cytokines