In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain

Background Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with COVID-19 compared to non-IS patients. Methods We designed a retrospective cohort study. We included all patients hospitalized with laboratory-confirmed COVID-19 from the SEMI-COVID-19 Registry, a large multicentre national cohort in Spain, from March 27th until June 19th, 2020. We used multivariable logistic regression to assess the adjusted odds ratios (aOR) of in-hospital death among IS compared to non-IS patients. Results Among 13 206 included patients, 2 111 (16.0%) were IS. A total of 166 (1.3%) patients had solid organ (SO) transplant, 1081 (8.2%) had SO neoplasia, 332 (2.5%) had hematologic neoplasia, and 570 (4.3%), 183 (1.4%) and 394 (3.0%) were receiving systemic steroids, biological treatments, and immunosuppressors, respectively. Compared to non-IS patients, the aOR (95% CI) for in-hospital death was 1.60 (1.43–1.79) for all IS patients, 1.39 (1.18–1.63) for patients with SO cancer, 2.31 (1.76–3.03) for patients with haematological cancer and 3.12 (2.23–4.36) for patients with SO transplant. The aOR (95% CI) for death for patients who were receiving systemic steroids, biological treatments and immunosuppressors compared to non-IS patients were 2.16 (1.80–2.61), 1.97 (1.33–2.91) and 2.06 (1.64–2.60), respectively. IS patients had a higher odds than non-IS patients of in-hospital acute respiratory distress syndrome, heart failure, myocarditis, thromboembolic disease and multiorgan failure. Conclusions IS patients hospitalized with COVID-19 have a higher odds of in-hospital complications and death compared to non-IS patients

Berezin Quantization of Gauged WZW and Coset Models

Gauged WZW and coset models are known to be useful to prove holomorphic factorization of the partition function of WZW and coset models. In this note we show that these gauged models can be also important to quantize the theory in the context of the Berezin formalism. For gauged coset models Berezin quantization procedure also admits a further holomorphic factorization in the complex structure of the moduli space.Comment: 15+1 pages, no figures, revte

Expression profiling and localization of wall polysaccharides in the olive pollen during in vitro germination

1 página.-- Comunicación oral presentada en la XVIII Reunión de la Sociedad Española de Fisiología Vegetal (SEFV).-- Sesión Temática 2: Crecimiento y desarrollo.-- S2-O2.This work was supported by the Andalusian Regional Government (project P06-AGR-01791). C. Suarez thanks the MEC for providing FPI grant funding.Peer reviewe

Mortality due to non-AIDS-defining cancers among people living with HIV in Spain over 18 years of follow-up

Cancer; HIV; MortalityCáncer; VIH; MortalidadCàncer: VIH; MortalitatPurpose Our aim was to describe non-AIDS-defining cancer (NADC) mortality among people living with HIV (PLWH), to compare it with that of the general population, and to assess potential risk factors. Methods We included antiretroviral-naive PLWH from the multicentre CoRIS cohort (2004–2021). We estimated mortality rates and standardised mortality ratios (SMRs). We used cause-specific Cox models to identify risk factors. Results Among 17,978 PLWH, NADC caused 21% of all deaths observed during the follow-up. Mortality rate due to NADC was 1.58 (95%CI 1.36, 1.83) × 1000 person-years and lung and liver were the most frequent cancer-related causes of death. PLWH had 79% excess NADC mortality risk compared to the general population with the highest SMR found for Hodgkin lymphoma, anal and liver cancers. The SMRs decreased with age and were the highest in age groups under 50 years. The most important prognostic factor was low CD4 count, followed by smoking, viral hepatitis and HIV transmission through heterosexual contact or injection drug use. Conclusion Non-AIDS cancers are an important cause of death among PLWH. The excess mortality related to certain malignancies and the association with immunodeficiency, smoking, and coinfections highlights the need for early detection and treatment of cancer in this population.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This research was supported by CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB21/13/00091), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU, the Gilead Scholarship Program for Biomedical Research (GLD19_00106) and the ISCIII- Miguel Servet CP19CIII—00002 contract

Epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole for six Candida species as determined by the colorimetric Sensititre YeastOne method

In the absence of clinical breakpoints (CBP), epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of susceptibility tests. Sensititre YeastOne (SYO) is a widely used method to determine susceptibility of Candida spp. to antifungal agents. The CLSI CBP have been established, but not for the SYO method. The ECVs for four azoles, obtained using MIC distributions determined by the SYO method, were calculated via five methods (three statistical methods and based on the MIC50 and modal MIC). Respectively, the median ECVs (in mg/liter) of the five methods for fluconazole, itraconazole, posaconazole, and voriconazole (in parentheses: the percentage of isolates inhibited by MICs equal to or less than the ECVs; the number of isolates tested) were as follows: 2 (94.4%; 944), 0.5 (96.7%; 942), 0.25 (97.6%; 673), and 0.06 (96.7%; 849) for Candida albicans; 4 (86.1%; 642), 0.5 (99.4%; 642), 0.12 (93.9%; 392), and 0.06 (86.9%; 559) for C. parapsilosis; 8 (94.9%; 175), 1 (93.7%; 175), 2 (93.6%; 125), and 0.25 (90.4%; 167) for C. tropicalis; 128 (98.6%; 212), 4 (95.8%; 212), 4 (96.0%; 173), and 2 (98.5; 205) for C. glabrata; 256 (100%; 53), 1 (98.1%; 53), 1 (100%; 33), and 1 (97.9%; 48) for C. krusei; 4 (89.2%; 93), 0.5 (100%; 93), 0.25 (100%; 33), and 0.06 (87.7%; 73) for C. orthopsilosis. All methods included =94% of isolates and yielded similar ECVs (within 1 dilution). These ECVs would be suitable for monitoring emergence of isolates with reduced susceptibility by using the SYO method

Reversión de sedantes agonistas alfa-2-adrenérgicos en el perro

En el presente Artículo de Revisión se aporta una información amplia sobre los productos de LISO más frecuente en la reversión de los efectos sedantes de los agonistas alfa-2-adrenérgicos empleados en el perro: xilacina, medetomidina y romifidina. Se refieren los detalles farmacológicos, dosificación, efectos y aplicaciones de los siguientes productos: yohimbina, 4-aminopiridina, doxapram y atipamezol

Modulation of argon pressure as an option to control transmittance and resistivity of ZnO:Al films deposited by DC magnetron sputtering: on the dark yellow films at 10^-7 Torr base pressures

In a previous paper, we reported that thin films of ZnO:Al [aluminum-zinc oxide (AZO)] deposited after achieving a very low base pressure [from 4.0×10-7 Torr (5.6×10-5 Pa) to 5.7×10-7 Torr (7.6×10-5 Pa)] result dark yellow in color and are resistive. These are undesirable characteristics for the application of AZO thin films as front electrodes in solar cells. However, given the increasingly tendency in the acquisition of equipment that allow us to reach excellent vacuum levels, it is necessary to find the deposition conditions that lead to an improving of transmittance without greatly impacting the electrical properties of materials deposited after achieving these levels of vacuum. In this way, the present work is focused on AZO thin films deposited after achieving a very low base pressure value: 4.2×10-7 Torr (5.6×10-5 Pa). For this, we studied the effect of the variation of the oxygen volume percent in the argon/oxygen mixture (by maintaining the deposition pressure constant) and the effect of deposition pressure with only argon gas on the main properties of AZO thin films. The depositions were done at room temperature on glass substrates by direct-current magnetron sputtering with a power of 120 W (corresponding to a power density of 2.63 W/cm2). As results, we found that the variation of deposition pressure with only argon gas is a good option for the control of optical and electrical properties, since the addition of oxygen, although improves transmittance, greatly impacts on the electrical properties. Furthermore, an interesting correlation was found between the optical and electrical properties and the chemical composition of the AZO films, the latter depending on the argon pressure (for this, a careful X-ray photoelectron spectroscopy analysis was performed). Also, the inverse relationship between crystallinity and deposition rate was confirmed, in which deposition rate inversely depends on argon pressure

Bose-Einstein condensate dark matter phase transition from finite temperature symmetry breaking of Klein-Gordon fields

In this paper the thermal evolution of scalar field dark matter particles at finite cosmological temperatures is studied. Starting with a real scalar field in a thermal bath and using the one loop quantum corrections potential, we rewrite Klein-Gordon's (KG) equation in its hydrodynamical representation and study the phase transition of this scalar field due to a Z_2 symmetry breaking of its potential. A very general version of a nonlinear Schr\"odinger equation is obtained. When introducing Madelung's representation, the continuity and momentum equations for a non-ideal SFDM fluid are formulated, and the cosmological scenario with the SFDM described in analogy to an imperfect fluid is then considered where dissipative contributions are obtained in a natural way.Additional terms appear compared to those obtained in the classical version commonly used to describe the \LambdaCDM model, i.e., the ideal fluid. The equations and parameters that characterize the physical properties of the system such as its energy, momentum and viscous flow are related to the temperature of the system, scale factor, Hubble's expansion parameter and the matter energy density. Finally, some details on how galaxy halos and smaller structures might be able to form by condensation of this SF are given.Comment: Substantial changes have been made to the paper, following the referees recommendations. 16 pages. Published in Classical and Quantum Gravit