Kepercayaan Diri Dan Kematangan Karir Remaja Penerima Manfaat Di Balai Rehabilitasi Sosial Wira Adhi Karya Ungaran

Kematangan karir diperlukan agar remaja penerima manfaat di Balai Rehabilitasi Sosial mampu memilih pekerjaan yang melibatkan kemampuan dalam merencanakan dan membuat keputusan karir sehingga setelah purna bina dapat menekuni suatu bidang pekerjaan atau membantu peningkatan kesempatan mengenyam pendidikan tinggi. Penelitian ini bertujuan untuk meneliti hubungan antara kepercayaan diri dan kematangan karir remaja penerima manfaat di Balai Rehabilitasi Sosial Wira Adhi Karya Ungaran. Subjek dalam penelitian ini adalah remaja penerima manfaat angkatan pertama tahun 2015 di Balai Rehabilitasi Sosial Wira Adhi Karya Ungaran. Peneliti menggunakan teknik sampling jenuh dengan jumlah 46 remaja penerima manfaat. Metode pengumpulan data menggunakan dua skala psikologi yaitu, Skala Kematangan Karir yang disusun berdasarkan aspek kematangan karir menurut Super (34 aitem, α = 0,845) serta Skala Kepercayaan Diri yang disusun berdasarkan aspek kepercayaan diri menurut Lauster (24 aitem, α = 0,782). Analisis data dilakukan dengan metode analisis regresi sederhana. Hasil analisis data menunjukkan adanya hubungan positif dan signifikan antara kepercayaan diri dan kematangan karir pada remaja penerima manfaat di Balai Rehabilitasi Sosial Wira Adhi Karya Ungaran (rxy = 0,690, p < 0,001). Semakin tinggi kepercayaan diri, maka semakin tinggi pula kematangan karir remaja penerima manfaat. Efektivitas regresi penelitian ini sebesar 47,6% artinya kematangan karir remaja penerima manfaat 47,6% ditentukan oleh kepercayaan diri. Kematangan karir dan kepercayaan diri remaja penerima manfaat rata-rata berada pada kategori tinggi

Currently Available Tools and Teaching Strategies for the Interprofessional Education of Students in Health Professions : Literature review

Interprofessional education (IPE) is designed to provide students from different health sectors with opportunities to work together to enhance future collaboration. The implementation of IPE activities is a current trend in various countries. This review exclusively targets IPE issues involving undergraduate health profession students and highlights various approaches in different regions. A total of 28 articles published in peer-reviewed journals between January 2012 and July 2015 were assessed to determine recent trends in IPE implementation. Nine main strategies were identified: simulation-based education programmes; rotations in rural and community settings; interprofessional training wards; patient-centred case studies; theme-centred workshops; student seminars; student-delivered lectures; health promotion activities; and interactive lectures in a common setting. Many of these institutions had not restricted themselves to a single strategy and supplemented these activities with additional teaching or learning methods. Recommendations gathered from these diverse approaches may assist the development of sustainable strategies for implementing IPE in undergraduate medical curricula

Toxic effect of naphta exposure on respiratory system among workers in the tyre industry

A cross-sectional study was carried out on workers in a tyre manufacturing industry in Malaysia to determine the effects of naphtha exposure on lung functions and respiratory symptoms. Sixty male workers exposed to naphtha and 42 unexposed workers were selected for this study. Personal air monitoring carried out using solid sorbent tubes and low flow pumps (Model: PAS-500 Personal Air Sampler). Personal air monitoring showed that the mean air naphtha concentration was 28.50 mg/m3, the median was 28.47 mg/m3 and the inter quartile range of 1.27 mg/m3. The range was from 0.19 to 200.51 mg/m3 (PEL is 400 mg/m3). The lung function tests showed in 2 groups for all the 3 parameters (FVC%, FEV1% and FEV1/FVC) were in exposed group 96.16, 85.23 and 0.791 respectively and in Unexposed group was 113.23, 116.28 and 0.903 respectively. The lung function tests showed that there were significant difference in the 2 groups for FVC% (p < 0.001), FEV1% (p < 0.001) and FEV1/FVC% (p =0.002). Multiple linear regression test showed that monthly household income significantly influence the FVC% predicted (b = 0.003, p < 0.001) and FEV1% predicted (b = 0.006, p < 0.001). In conclusion there was an inverse relationship between air naphtha concentrations and lung functions ability. Early impairment of the respiratory system is detected on the workers who are exposed to naphtha which made up of several chemicals

Multi-component quantitation of loratadine, pseudoephedrine and paracetamol in plasma and pharmaceutical formulations with liquid chromatography-tandem mass spectrometry utilizing a monolithic column

The purpose of this study was to develop a rapid, simple and sensitive quantitation method for pseudoephedrine (PSE), paracetamol (PAR) and loratadine (LOR) in plasma and pharmaceuticals using liquid chromatography-tandem mass spectrometry with a monolithic column. Separation was achieved using a gradient composition of methanol-0.1% formic acid at a flow rate of 1.0 mL min-1. Mass spectral transitions were recorded in SRM mode. System validation was evaluated for precision, specificity and linearity. Limit of detection for pseudoephedrine, paracetamol, and loratadine were determined to be 3.14, 1.86 and 1.44 ng mL-1, respectively, allowing easy determination in plasma with % recovery of 93.12 to 101.56%

Perjanjian Perkawinan Pasca Putusan Mahkamah Konstitusi Nomor 69/PUU-XIII/2015

Pada tesis ini, penulis akan mengangkat permasalahan mengenai Perjanjian Perkawinan Pasca Putusan Mahkamah Konstitusi Noomor 69/PUU-XIII/2015. Pilihan tema tersebut dilatar belakangi oleh adanya perbedaan peraturan antara Kitab Undang-Undang Hukum Perdata, Undang-Undang Nomor 1 Tahun 1974, Kompilasi Hukum Islam dengan Putusan Mahkamah Konstitusi Nomor 69/PUU-XIIII/2015. Berdasarkan hal tersebut diatas, karya tulis ini mengangkat rumusan masalah : (1) Apakah dasar pеrtimbangan hukum hakim Mahkamah Konstitusi mеngijinkan pеrjanjian pеrkawinan dilakukan sеtеlah pеrkawinan tеlah sеsuai dеngan nilai-nilai kеadilan ? (2) Apakah pеrlindungan hukum tеrhadap harta bеnda dari pеrjanjian pеrkawinan yang dibuat sеtеlah pеrkawinan apabila ada salah satu pihak yang dirugikan ? Kemudian penulisan karya tulis ini menggunakan metode penelitian yuridis normatif dengan metode pendekatan perundang-undangan (statute approach). Bahan hukum primer dan sekunder yang diperoleh penulis, akan dianalisis dengan menggunakan teknik analis bahan hukum dilakukan dengan teknik deskriptif, teknik evaluatif dan teknik argumentatif berdasarkan teori yang kemudian dikaji lebih lanjut sesuai dengan permasalahan yang ada agar diperoleh pemecahan yang jelas. Berdasarkan hasil penelitian, maka dapat disimpulkan bahwa Perjanjian Perkawinan yang dibuat setelah perkawinan berlangsung dapat berpotensi menimbulkan kerugian dan ketidak adilan bagi pihak ketiga. Kepentingan pihak ketiga juga menjadi tidak terlindungi. Mengenai waktu berlakunya Perjanjian Perkawinan yang dibuat setelah perkawinan berlangsung serta dalam Putusan Mahkamah Konstitusi Nomor 69/PUU-XIII/2015 dalam amar putusannya yang terdapat dalam poin 1.5. dan 1.6. menimbulkan suatu ketidakpastian hukum. Pihak ketiga dan pihak suami atau istri yang dirugikan dengan pembuatan Perjanjian Perkawinan setelah perkawinan berlangsung dapat menuntut ganti rugi dan pembatalan ke Pengadilan Negeri

Deconstructing the sscatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

APC is a key tumor suppressor and Wnt signaling regulator, but its mechanism of action remains mysterious. We combined parallel assays in Drosophila and cultured human colon cancer cell lines to test hypotheses regarding APC function and to develop novel hypotheses, using mutants altering its structure in specific ways.Negatively regulating signaling by targeting key effectors for ubiquitina­tion/destruction is essential for development and oncogenesis. The tumor suppressor adenomatous polyposis coli (APC), an essential negative regulator of Wnt signaling, provides a paradigm. APC mutations occur in most colon cancers. Acting in the “destruction complex” with Axin, glycogen synthase kinase 3, and casein kinase, APC targets ßcatenin (ßcat) for phosphorylation and recognition by an E3 ubiquitin-ligase. Despite 20 years of work, the internal workings of the destruction complex and APC's role remain largely mysterious. We use both Drosophila and colon cancer cells to test hypotheses for APC's mechanism of action. Our data are inconsistent with current models suggesting that high-affinity ßcat-binding sites on APC play key roles. Instead, they suggest that multiple ßcat-binding sites act additively to fine-tune signaling via cytoplasmic retention. We identify essential roles for two putative binding sites for new partners—20-amino-acid repeat 2 and conserved sequence B—in destruction complex action. Finally, we demonstrate that APC interacts with Axin by two different modes and provide evidence that conserved sequence B helps ensure release of APC from Axin, with disassembly critical in regulating ßcat levels. Using these data, we suggest a new model for destruction complex action in development, which also provides new insights into functions of truncated APC proteins in cancer

Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network.

OBJECTIVE: This report presents data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network on care of and morbidity and mortality rates for very low birth weight infants, according to gestational age (GA). METHODS: Perinatal/neonatal data were collected for 9575 infants of extremely low GA (22-28 weeks) and very low birth weight (401-1500 g) who were born at network centers between January 1, 2003, and December 31, 2007. RESULTS: Rates of survival to discharge increased with increasing GA (6% at 22 weeks and 92% at 28 weeks); 1060 infants died at CONCLUSION: Although the majority of infants with GAs of \u3eor=24 weeks survive, high rates of morbidity among survivors continue to be observed

Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a Novel Anti-Inflammatory Drug Candidate

BACKGROUND: 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole (DIC) is a five-membered heterocyclic compound containing a N-O bond. The anti-inflammatory effects of this compound were studied both in vitro and in vivo. PRINCIPAL FINDINGS: DIC effectively decreased TNF-α and IL-6 release from LPS-stimulated macrophages in a dose dependent manner. DIC diminished the levels of COX-2 with subsequent inhibition of PGE(2) production. DIC also compromised HMGB1 translocation from the nucleus to the cytoplasm. Moreover, DIC prevented the nuclear translocation of NF-κB and inhibited the MAPK pathway. In vivo, DIC inhibited migration of neutrophils to the peritoneal cavity of mice. CONCLUSIONS: This study presents the potential utilization of a synthetic compound, as a lead for the development of novel anti-inflammatory drugs