The East-West Arc, Re-thinking Growth in the London Region

The East-West Arc spans 30 local councils comprising the growth corridor from Oxford through Milton Keynes and Northampton to Cambridge. Its population of over three million is the fastest growing region in the UK . It forms the northern fringe of the greater London city region to which it is profitably tied, just north of the Green Belt. History, knowledge, technology, agriculture and nature combine in a rich tapestry that has long contributed to the commonwealth of the United Kingdom. In a globalizing world where distances of all kinds are slashed, the Arc is more than a key part of the greater London region. It is a gateway north to the Midlands and the Northern Powerhouse. The Oxford-Milton Keynes-Cambridge Gateway is one of the most innovative and dynamic areas of the UK. Its potential is recognised by the government as a once-in-a-generation opportunity for the region to become a ‘knowledge-intensive growth cluster, competing globally’. Yet that potential is capped by inadequate infrastructure and expensive housing, as well as ecological constraints. As HS2, along with the train and expressway linking Oxford and Cambridge become realities, this vital region can be seen better as a gateway in all directions, thus helping to rebalance growth across the UK. The day-long symposium on the East-West Arc held at the University of Westminster in June of 2018 addressed these challenges from a range of perspectives. Traversing the Arc from south to north is the proposed high-speed rail line HS2, as well as the planned east-west expressway and east-west rail line linking Oxford to Cambridge through Milton Keynes. These transport links, taken together, are intended to enhance connectivity, mobility and productivity across the region. This will further boost growth while presenting financing and environmental challenges along with its benefits. The National Infrastructure Commission (NIC) report from 2017, Partnering for Prosperity: A new deal for the Cambridge-Milton Keynes-Oxford Arc, set out one vision and approach to infrastructure-led development linked to place making. It also set out new thinking on the housing challenge in the region that is equivalent to a new city the size of Birmingham. Other impacts of growth also need to be addressed, such as last mile connectivity and multi-modal transport, social inequities, land consumption of agriculture and forests, greater flood risk, pollution, and loss of ecological function and integrity of historical region including its villages and towns. These are but a few of the impacts that need to be addressed by an assessment of growth scenarios and their impacts, in advance of the foreseen major infrastructure projects. Government has long recognised the strategic importance of the Arc, and not just to the region itself, comprised of three recently-formed regional growth boards in Milton Keynes, Oxford and Cambridge. Central to the Arc is its relationship to London, the west of England and the synergies with the Midlands and further north. This greater London Region contains the UK’s primary transport hubs and corridors, including the main north-south road and rail routes, together with key international gateways such as Heathrow and Birmingham airports and the seaports of Harwich, Felixstowe and the Thames Gateway in the east. While the long history of this greater region has unfolded piece meal, it is now interconnected into a functioning mega-region that needs a coherent strategy founded by cogent analysis. In this context, it is critical to envision the East-West Arc as gateway that enables in all directions, and not merely as a self-contained sub-region or as a northern fringe of London

Effectiveness and safety of betrixaban extended prophylaxis for venous thromboembolism compared with standard-duration prophylaxis intervention in acute medically ill patients : a systematic literature review and network meta-analysis

Aims: To determine the clinical effectiveness and safety of venous thromboembolism (VTE) prophylaxis using US- and Europe-approved anticoagulants relative to extended-duration VTE prophylaxis with betrixaban. Low molecular weight heparins (LMWHs), unfractionated heparin (UFH), fondaparinux sodium and placebo were each compared to betrixaban, as standard-duration VTE prophylaxis for hospitalized, non-surgical patients with acute medical illness at risk of VTE. Materials and methods: A systematic literature review was conducted up to June 2019 to identify randomized controlled trials (RCTs) of VTE prophylaxis in hospitalized, non-surgical patients with acute medical illness at risk of VTE. Studies that reported the occurrence of VTE events (including death) and, where possible, major bleeding, from treatment initiation to 20–50 days thereafter were retrieved and extracted. A Bayesian fixed effect network meta-analysis was used to estimate efficacy and safety of betrixaban compared with standard-duration VTE prophylaxis. Results: Seven RCTs were analyzed which compared betrixaban, LMWHs, UFH, fondaparinux sodium, or placebo. There were significantly higher odds (median odds [95% credible interval]) of VTE with LMWHs (1.38 [1.12–1.70]), UFH (1.60 [1.05–2.46]), and placebo (2.37 [1.55–3.66]) compared with betrixaban. There were significantly higher odds of VTE-related death with placebo (7.76 [2.14–34.40]) compared with betrixaban. No significant differences were observed for the odds of major bleeding with all comparators, VTE-related death with any active standard-duration VTE prophylaxis, or of VTE with fondaparinux sodium, compared with betrixaban. Limitations and conclusions: In this indirect comparison, betrixaban was shown to be an effective regimen with relative benefits compared with LMWHs and UFH. This indicates that betrixaban could reduce the burden of VTE in at-risk hospitalized patients with acute medical illness who need extended prophylaxis, though without direct comparative evidence, stronger conclusions cannot be drawn

Directed Design of a AuI Complex with a Reduced Mesoionic Carbene Radical Ligand: Insights from 1,2,3‐Triazolylidene Selenium Adducts and Extensive Electrochemical Investigations

Carbene-based radicals are important for both fundamental and applied chemical research. Herein, extensive electrochemical investigations of nine different 1,2,3-triazolylidene selenium adducts are reported. It is found that the half-wave potentials of the first reduction of the selones correlate with their calculated LUMO levels and the LUMO levels of the corresponding triazolylidene-based mesoionic carbenes (MICs). Furthermore, unexpected quasi-reversibility of the reduction of two triazoline selones, exhibiting comparable reduction potentials, was discovered. Through UV/Vis/NIR and EPR spectroelectrochemical investigations supported by DFT calculations, the radical anion was unambiguously assigned to be triazoline centered. This electrochemical behavior was transferred to a triazolylidene-type MIC-gold phenyl complex resulting in a MIC-radical coordinated Au-I species. Apart from UV-Vis-NIR and EPR spectroelectrochemical investigations of the reduction, the reduced gold-coordinated MIC radical complex was also formed in situ in the bulk through chemical reduction. This is the first report of a monodentate triazolylidene-based MIC ligand that can be reduced to its anion radical in a metal complex. The results presented here provide design principles for stabilizing radicals based on MICs

CAAC‐Based Thiele and Schlenk Hydrocarbons

Diradicals have been of tremendous interest for over a century ever since the first reports of p ‐ and m ‐phenylene‐bridged diphenylmethylradicals in 1904 by Thiele and 1915 by Schlenk. Reported here are the first examples of cyclic(alkyl)(amino)carbene (CAAC) analogues of Thiele's hydrocarbon, a Kekulé diradical, and Schlenk's hydrocarbon, a non‐Kekulé diradical, without using CAAC as a precursor. The CAAC analogue of Thiele's hydrocarbon has a singlet ground state, whereas the CAAC analogue of Schlenk's hydrocarbon contains two unpaired electrons. The latter forms a dimer, by an intermolecular double head‐to‐tail dimerization. This straightforward synthetic methodology is modular and can be extended for the generation of redox‐active organic compounds