Oral contrast-enhanced CT cholangiography--an initial experience

Objective: To describe our experience of CT (Computed tomographic) Cholangiography examination for detection of choledocholithiasis at the Aga Khan University Hospital (AKUH) Karachi Pakistan.Methods: Seven patients underwent helical CT cholangiography for suspected choledocholithiasis. Iopanoic acid (6 grams) was administered orally 8-12 hours before acquisition of a helical CT cholangiogram. Three-dimensional reconstructions and curved multiplanar reformations were generated from a set of axial source images.Results: Our patients had no adverse reactions to iopanoic acid. The degree of biliary opacification was sufficient to perform three-dimensional and curved planar reformations in 5 patients. In two patients, the biliary tree was not opacified. Both of these studies were considered failures. Findings on CT cholangiography in the remaining 5 patients were the following: cholelithiasis with normal bile duct (n=2), choledocholithiasis (n=1), stone in gallbladder remnant with long cystic duct (n=1) and infiltrating adenocarcinoma of the gallbladder (n=1).CONCLUSION: Spiral CT cholangiography is a safe, non-invasive, and cost effective alternative test and, in a carefully selected patient population can play a role in the diagnostic work-up of patients with suspected choledocholithiasis

Robust human face detection in complex color images

We propose in this paper a model based technique for the detection of human faces from rich still color images. Traditionally, color images are represented in the RGB color space. RGB space, however, is not only a 3-dimensional space but also includes brightness or luminance which is not a reliable criterion for skin separation. To avoid the effect of luminance, we propose to work in the chromatic or pure color space. Using such space, a Gaussian model for the skin color pixels is developed and a skin likelihood image is obtained. Such image is then transformed into a binary image using adaptive thresholding. Finally, bright regions satisfying certain "facial" properties are obtained followed by a template matching stage. The method presented here is shown to provide robust detection under different environments and found to achieve very satisfactory results when compared to traditional "mug shot" based approaches

Robust human face detection in complex color images

We propose in this paper a model based technique for the detection of human faces from rich still color images. Traditionally, color images are represented in the RGB color space. RGB space, however, is not only a 3-dimensional space but also includes brightness or luminance which is not a reliable criterion for skin separation. To avoid the effect of luminance, we propose to work in the chromatic or pure color space. Using such space, a Gaussian model for the skin color pixels is developed and a skin likelihood image is obtained. Such image is then transformed into a binary image using adaptive thresholding. Finally, bright regions satisfying certain "facial" properties are obtained followed by a template matching stage. The method presented here is shown to provide robust detection under different environments and found to achieve very satisfactory results when compared to traditional "mug shot" based approaches

CHOLINE-UTILIZING MICROBLAL STRAINS FOR BIOLOGICALLY CONTROLLING FUSARIUM HEAD BLIGHT

Three choline utilizing strains of microorganisms isolated from the anthers of wheat, Aureobasidium pullulans strainAS 55.2, Arthrobacter species strain OH 221.3, and Pseudomonas species strain AS 64.4, are superior antagonists of F. graminearum. These microorganisms are effective for suppression and control of FHB in cereals, particularly in wheat and barley

A descriptive analysis of research culture in Pakistan

This study addresses evolution of research culture in Pakistan. The study is descriptive in nature. The primary analysis is related to 180 Pakistani universities and 13259 PhDs produced from these universities since 1947 till 2016 along with their different contextual ratios such as geography, gender, public, and private sectors, universities and number of produced PhDs, supervisor and number of produced PhDs ratios, era wise growth of number of universities and produced PhDs. The study accounts for benchmark changes in leadership and resources as impacting factors for change in number of universities and produced number of Doctoral Researches (PhDs). The primary source for data is HEC while respective websites of the universities (if available) are also explored for the missing data. The study documents relatively recent emergence of certain assets in terms of a research culture and anticipates an opportunity to build upon these assets in future. Public universities with more experience are taking lead in almost all domains such as increase in number of universities and PhDs produced, their geographic and gender diversity, and supervisor to PhDs ratio etc. and private and relevantly new universities lag behind. If these could also start contributing soon Pakistan could muster the fruit of a rich research culture

Processing of Sr2+ Containing Poly L-Lactic Acid-Based Hybrid Composites for Additive Manufacturing of Bone Scaffolds

Biodegradable composite materials represent one of the major areas of investigation for bone tissue engineering due to their tuneable compositional and mechanical properties, which can potentially mimic those of bone and potentially avoid the removal of implants, mitigating the risks for the patient and reducing the overall clinical costs. In addition, the introduction of additive manufacturing technologies enables a strict control over the final morphological features of the scaffolds. In this scenario, the optimisation of 3D printable resorbable composites, made of biocompatible polymers and osteoinductive inorganic phases, offers the potential to produce a chemically and structurally biomimetic implant, which will resorb over time. The present work focuses on the development and process optimisation of two hybrid composite filaments, to be used as feedstock for the fused filament fabrication 3D printing process. A Poly L-lactic acid matrix was blended with either rod-like nano-hydroxyapatite (nano-HA) or nanoparticles of mesoporous bioactive glasses, both partially substituted with strontium (Sr2+), due to the well-known pro-osteogenic effect of this ion. Both inorganic phases were incorporated into Poly L-lactic acid using an innovative combination of processes, obtaining a homogeneous distribution throughout the polymer whilst preserving their ability to release Sr2+. The filament mechanical properties were not hindered after the incorporation of the inorganic phases, resulting in tensile strengths and moduli within the range of cancellous bone, 50 ± 10 MPa and 3 ± 1 GPa. Finally, the rheological characterization of the hybrid composites indicated a shear thinning behaviour, ideal for the processing with fused filament fabrication, proving the potential of these materials to be processed into 3D structures aiming bone regeneration

Complexation of BaCl 2 with glutathione (GSH) in blood components

Barium is a divalent alkaline earth metal and can exist only in combination forms. Studies have proved that barium can cause different toxic effects. The human body can be exposed to barium in drinking water, food and air. In medical field, barium is used in diagnostic procedure. Among its various combinations, barium chloride is considered most important in its related toxicities, because of its water solubility. In the human body, glutathione is present in almost all type of cells and acts as an antioxidant and also arrests the toxic xenobiotics like metals and drugs through conjugate formation. This study was designed to investigate the possible interaction of barium with extracellular (separatedplasma) glutathione (GSH) and intracellular (separated-cytosolic fraction) GSH. The renowned Ellman's method of thiol quantification was used to determine the effect of barium chloride on the levels of extracellular and intracellular GSH. The results showed that a decrease in the concentration of GSH was affected by barium chloride. This decrease was enhanced by increasing the concentrations of barium chloride and also by the time elapsed. Hypothetically, this decrease in the levels of GSH may be attributed to the conjugation formation of GSH with barium metal