371 research outputs found

    The layer by layer selective laser synthesis of ruby

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    In the work, features of the layer-by-layer selective laser synthesis (SLS) of ruby from an Al2O3-Cr2O3 mixture are considered depending on the irradiation power, the laser beam traverse speed, the height and amount of the backfill of powder layers. It has been established that, under irradiation, a track consisting of polycrystalline textured ruby forms. The morphology of the surface of the track and its crystalline structure are determined by the irradiation conditions

    Дослідження хімічного складу та протизапальної активності екстрактів сухих з журавлини великоплодої листя

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    Inflammation accompanies huge numbers of diseases. In case of inflammation, non-steroidal anti-inflammatory drugs are used, but they have a number of side effects and disadvantages. In turn, medicines based on the medicinal plant raw material that exhibit the anti-inflammatory activity, on the contrary, are underestimated and insufficientlystudied. An interesting object in this direction is large cranberry leaves of Ericaceae family. Aim. To study the chemical composition and the anti-inflammatory activity of extracts from large cranberry leaves to establish the prospect of creating new drugs with the anti-inflammatory activity. Materials and methods. The study objects were dry extracts from large cranberry (Oxycoccus macrocarpus (Ait.)) leaves. The chemical analysis of the extracts was studied by TLC and spectrophotometry methods. The anti-inflammatory activity of the extracts was studied on the model of carrageenan edema. Results and discussion. Hyperoside and chlorogenic acid were identified in the extracts. In the dry extract from large cranberry leaves, the content of the total amount of derivatives of hydroxycinnamic compounds was 11.60 ± 0.05 %, and in the modified extract – 3.09 ± 0.05 %. The anti-exudative activity was more pronounced in the group of animals that received the cranberry extract with arginine in the dose of 100 mg/kg. Conclusions. Identification and the quantification of biologically active substances in large cranberry leaves extracts have been carried out; their anti-inflammatory activity has been determined.Запалення супроводжує велику кількість захворювань. Для лікування запалення використовують нестероїдні протизапальні засоби, які мають низку побічних дій та недоліків. Своєю чергою препарати на основі лікарської рослинної сировини, які проявляють протизапальну активність, навпаки є недооціненими та недостатньо вивченими. Цікавим об’єктом у цьому напрямі постає журавлини великоплодої листя родини Вересових (Ericaceae). Метою роботи було дослідити хімічний склад та протизапальну активність екстрактів із журавлини великоплодої листя для визначення перспективи створення нових лікарських засобів з протизапальною дією. Матеріали та методи. Об’єктами дослідження були екстракти сухі із журавлини великоплодої листя (Oxycoccus macrocarpus (Ait.)). Хімічний аналіз екстрактів вивчали методами ТШХ та спектрофотометрії. Протизапальну активність екстрактів вивчали на моделі карагенінового набряку. Результати та їх обговорення. В екстрактах сухих ідентифіковано гіперозид і хлорогенову кислоту. В екстракті сухому з журавлини великоплодої листя вміст суми похідних гідроксикоричних сполук становить 11,60 ± 0,05 %, а у модифікованому – 3,09 ± 0,05 %. Антиексудативна активність більш виражена в групі тварин, які отримували екстракт журавлини великоплодої з аргініном у дозі 100 мг/кг. Висновки. Проведено ідентифікацію та кількісне визначення біологічно активних речовин в екстрактах журавлини великоплодої листя та визначено їхню протизапальну активність

    Budgetary tax instruments of the innovative activity stimulation

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    Досліджено важелі державного стимулювання інноваційної активності в економіці країни. Розглянуто іноземний досвід податкового стимулювання інноваційної діяльності. Визначено проблеми застосування бюджетно-податкових стимулів і чинники, що стримують розвиток інноваційної діяльності в Україні.The article deals with the investigation instruments of the public stimulation of the innovative activity in economy. The authors analyzed the international experience of tax incentives of innovation activity. Problems of using budgetary tax instruments and factors restraining of the innovative activity development in Ukraine have been defined

    A social portrait of the Russian trainer

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    The purposes of this paper are to survey Russian trainers to create a social portrait of the professional group and to identify features, which could be arranged as a foothold for transforming this group to a new level given the demands of the modern economy. This study integrates the use of quantitative and qualitative social research strategies to obtain, aggregate, and analyze data characterizing the professional group of trainers in the Russian vocational education and training (VET) system. The basic research was provided by questionnaires in all federal districts (as recognized by international law) of the Russian Federation. The quantitative poll of trainers was conducted by representative two-level sampling. A number of tables and charts provide a social portrait of the Russian trainer. The statistical data reveal the current level of trainers’ education as well as their length of service, distribution of vocations, and other significant features. The overall conclusion from these findings indicates that a typical representative of this professional group is a woman of average or slightly advanced age with a family, who has a VET or higher education, has served as a training officer for not less than 10 years, and who has either been recruited as a highly skilled worker or as a specialist. A typical representative feels the need to change something in the life and teaching of the young people that she knows. The research into trainers as a professional group was conducted first because of their uniformity, and secondly, their typicality as a pedagogical group. In many respects, the main characteristics of the social portrait are similar to characteristics of other professional groups in the Russian education system, such as secondary and post-secondary school teachers, and VET teachers. The study is based on one country. It is the first and only survey of its type in the Russian Federation. The paper provides a unique analysis of the situation with trainers in the VET system of the Russian Federation. © 2016 Kopnov et al

    Labor mobility as a developing factor of sustainable labor market development

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    Sustainable development of the modem labor market parametrically has a number of dependencies, among which the labor mobility does not only form the equilibrium, the balance of demand and supply of labor but also determines the determinant of the competence profile of the labor potential of the employe

    Latent risks of secondary vocational school teachers’ professional activity: results of sociological research

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    The article presents the results of sociological research of the work of secondary school teachers who do not have psychological and pedagogical education. The analysis of the sociological research data shows that 84.1% of teachers (the re-spondents) having no psychological and pedagogical education are of working age. Among them, 24.6% of teachers belong to the age group of up to 35 years. This leads to the problems and difficulties of modernization of vocational education. The main trends of secondary vocational education development for the next five years are updating of vocational education content, implementation of the federal government standards, professional standards, modern methods and educational technologies in the system of secondary vocational education. All these tasks cannot be fulfilled without a serious pedagogical trainingВ статье приводятся результаты социологического исследования профессиональной деятельности преподавателей СПО, не имеющих профессионально-педагогического образования. Анализ данных социологического исследования показывает, что 84,1 % преподавателей (из числа опрошенных), не имеющих профессионально-педагогического образования, находятся в наиболее активном трудоспособном возрасте. Среди них 24,6 % преподавателей, входящих в возрастную категорию до 35 лет. Это приводит к проблемам и затруднениям в реализации задач модернизации среднего профессионального образования. Основными направлениями развития системы СПО в ближайшее пятилетие станут обновление содержания профессионального образования и внедрение в системе СПО ФГОС, профессиональных стандартов, современных методик и образовательных технологий, которые нельзя освоить без серьезной педагогической подготовки. Для решения поставленных профессионально-педагогических задач сегодня уже недостаточно уровня витагенного и ситуативного педагогического опыта, имеющегося у преподавател

    Laser Therapy in Correction of Optimization of Surgical Endointoxication

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    The problem of endointoxication remains one of the most urgent in modern surgery. The severity of the intoxication syndrome is determined not only by the intensity of the entry of toxic substances into the bloodstream from the lesion focus, but also by the adequacy of the functioning of the main mechanisms of detoxification - elimination of toxins. Clinical and laboratory studies of 62 patients with acute peritonitis were performed. To this end, daily sessions of laser therapy with “Matrix” were conducted for 5 days after the operation, using a head of KLO3 (radiation with a wavelength of 635 nm, 2 mW). Laser irradiation of blood through the skin in the projection of the ulnar vein was performed for 30 minutes. Using laser therapy for patients with acute peritonitis led to the reduction of the endogenous intoxication severity. The level of medium-mass molecules (λ = 280 nm) decreased by 13.3-26.2% compared to the control, the level of average-weight molecules (λ = 254 nm) decreased by 15.5-32.6% (p <0.05) against the background of laser therapy. Thus, the use of laser therapy in patients with acute peritonitis has led to a decrease in the severity of endogenous intoxication. One of the significant components of this treatment is its ability to improve microcirculation and, as a result, to correct lipid peroxidation and hypoxia, which reduces catabolic phenomena (one of the sources of endogenous intoxication). Clinical and laboratory studies have established that the effectiveness of such treatment decreases with severe forms of peritonitis

    A new case of Acute Myeloid Leukemia with semi-cryptic t(7;21)(p22;q22)

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    Case report of a translocation : A new case of Acute Myeloid Leukemia with semi-cryptic t(7;21)(p22;q22)

    ВДОСКОНАЛЕННЯ ФОРМ І МЕТОДІВ ПІСЛЯДИПЛОМНОГО НАВЧАННЯ ЛІКАРІВ ПО МОДУЛЮ “ГАСТРОЕНТЕРОЛОГІЯ”

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    The aim of the work – formation of a desire for self-education and self-improvement, which is ensured by the use of modern technologies of interactive learning in the continuous postgraduate education of doctors at the module of Gastroenterology. The main body. The article presents the use of traditional and interactive methods of teaching, such as problem-oriented learning, focused learning, distance learning, computer testing with usage of the licensed computer program “Elex” at the module of Gastroenterology. There were characterized and analyzed their advantages and disadvantages. Conclusions. The use of various methods and forms of training in the continuous postgraduate education of doctors allows to activate the learning process itself, raise the level of training of those who study, direct all efforts to form students’ desire to self-education and self-improvement. All this contributes to the harmonious, creative and professional development of a doctor.Мета роботи – формування у практичного лікаря прагнень до самонавчання, самовдосконалення та самовиховання, що забезпечується використанням сучасних технологій інтерактивного навчання у безперервній післядипломній освіті лікарів по модулю “Гастроентерологія”. Основна частина. У статті висвітлено використання поряд із традиційними методами навчання інтерактивних методів, зокрема таких, як навчання, яке орієнтоване на проблему, концентроване навчання, дистанційне навчання, проведення комп’ютерного тестування за допомогою ліцензованої комп’ютерної програми “Elex” лікарів по модулю “Гастроентерологія”. Охарактеризовані та проаналізовані їх переваги та недоліки. Висновки. Використання різноманітних методів та форм  навчання  у безперервній післядипломній освіті лікарів дозволяє активувати сам процес навчання, підняти рівень підготовки тих, хто навчається, направити всі зусилля на формування у слухача прагнень до самонавчання та самовиховання. Все це сприяє гармонійному, творчому та професійному розвитку лікаря

    Неонатальный скрининг на тяжелую комбинированную иммунную недостаточность в России: прекрасное дале ко или завтрашняя реальность?

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    Mass screening of newborns in Russia for five hereditary diseases does not meet the requirements of the world community for the neonatal screening program. Success in the development of laboratory diagnostic technologies and active introduction of achievements in genetics and molecular biology into medical practice allow for the revision of the list of nosologies included in the national neonatal screening program by replacing the disease or adding new nosologies. The article discusses the possibility of including genetic testing for severe combined immune deficiency in the Newborn Screening Program in Russia. The results from a retrospective study of markers of naive T- and B-lymphocytes (TREC and KREC) in the group of children with immuno-dependent pathology developed in the first year of life are discussed. © 2017 Voprosy Sovremennoi Pediatrii - Current Pediatrics. All rights reserved
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