204 research outputs found
Non-converging hysteretic cycles in random spin networks
Behavior of hysteretic trajectories for cyclical input is investigated as a
function of the internal structure of a system modeled by the classical random
network of binary spins. Different regimes of hysteretic behavior are
discovered for different network connectivity and topology. Surprisingly,
hysteretic trajectories which do not converge at all are observed. They are
shown to be associated with the presence of specific topological elements in
the network structure, particularly with the fully interconnected spin groups
of size equal or greater than 4.Comment: 4 pages, 3 figure
Giant and reversible extrinsic magnetocaloric effects in La0.7Ca0.3MnO3 films due to strain
Large thermal changes driven by a magnetic field have been proposed for
environmentally friendly energy efficient refrigeration, but only a few
materials which suffer hysteresis show these giant magnetocaloric effects. Here
we create giant and reversible extrinsic magnetocaloric effects in epitaxial
films of the ferromagnetic manganite La0.7Ca0.3MnO3 using strain mediated
feedback from BaTiO3 substrates near a first-order structural phase transition.
Our findings should inspire the discovery of giant magnetocaloric effects in a
wide range of magnetic materials, and the parallel development of
nanostructured bulk samples for practical applications.Comment: 32 pages, 1 Table, 5 figures, supplementary informatio
Modelling endogenous insulin concentration in type 2 diabetes during closed-loop insulin delivery
GIP Does Not Potentiate the Antidiabetic Effects of GLP-1 in Hyperglycemic Patients With Type 2 Diabetes
Sensor Drift Compensation Using Fuzzy Interference System and Sparse-Grid Quadrature Filter in Blood Glucose Control
Comparison of CO2 trapping in highly heterogeneous reservoirs with Brooks-Corey and van Genuchten type capillary pressure curves
Geological heterogeneities essentially affect the dynamics of a CO2 plume in
subsurface environments. Previously we showed how the dynamics of a CO2 plume
is influenced by the multi-scale stratal architecture in deep saline
reservoirs. The results strongly suggest that representing small-scale features
is critical to understanding capillary trapping processes. Here we present the
result of simulation of CO2 trapping using two different conventional
approaches, i.e. Brooks-Corey and van Genuchten, for the capillary pressure
curves. We showed that capillary trapping and dissolution rates are very
different for the Brooks-Corey and van Genuchten approaches when heterogeneity
and hysteresis are both represented.Comment: 10 pages 6 figure
Thermal evolution of the Malá Fatra Mountains (Central Western Carpathians): insights from zircon and apatite fission track thermochronology.
A new methodology to assess the performance and uncertainty of source apportionment models II: The results of two European intercomparison exercises
The performance and the uncertainty of receptor models (RMs) were assessed in intercomparison exercises employing real-world and synthetic input datasets. To that end, the results obtained by different practitioners using ten different RMs were compared with a reference. In order to explain the differences in the performances and uncertainties of the different approaches, the apportioned mass, the number of sources, the chemical profiles, the contribution-to-species and the time trends of the sources were all evaluated using the methodology described in Belis et al. (2015). In this study, 87% of the 344 source contribution estimates (SCEs) reported by participants in 47 different source apportionment model results met the 50% standard uncertainty quality objective established for the performance test. In addition, 68% of the SCE uncertainties reported in the results were coherent with the analytical uncertainties in the input data. The most used models, EPA-PMF v.3, PMF2 and EPA-CMB 8.2, presented quite satisfactory performances in the estimation of SCEs while unconstrained models, that do not account for the uncertainty in the input data (e.g. APCS and FA-MLRA), showed below average performance. Sources with well-defined chemical profiles and seasonal time trends, that make appreciable contributions (>10%), were those better quantified by the models while those with contributions to the PM mass close to 1% represented a challenge. The results of the assessment indicate that RMs are capable of estimating the contribution of the major pollution source categories over a given time window with a level of accuracy that is in line with the needs of air quality management
Efficacy and Safety of Lacosamide in Painful Diabetic Neuropathy
OBJECTIVE: To evaluate efficacy and safety of lacosamide compared with placebo in painful diabetic polyneuropathy. RESEARCH DESIGN AND METHODS: Diabetic patients with at least moderate neuropathic pain were randomized to placebo or lacosamide 400 (in a slow or standard titration) or 600 mg/day over 6-week titration and 12-week maintenance periods. Primary efficacy criterion was intra-individual change in average daily Numeric Pain Rating Scale score from baseline to the last 4 weeks. RESULTS: For the primary end point, pain reduction was numerically but not statistically greater with lacosamide compared with placebo (400 mg/day, P = 0.12; 600 mg/day, P = 0.18). Both doses were significantly more effective compared with placebo over the titration (P = 0.03, P = 0.006), maintenance (P = 0.01, P = 0.005), and entire treatment periods (P = 0.03, P = 0.02). Safety profiles between titration schemes were similar. CONCLUSIONS: Lacosamide reduced neuropathic pain and was well tolerated in diabetic patients, but the primary efficacy criterion was not met, possibly due to an increased placebo response over the last 4 weeks.status: publishe
First order reversal curves and intrinsic parameter determination for magnetic materials; Limitations of hysteron-based approaches in correlated systems
The generic problem of extracting information on intrinsic particle properties from the whole class of interacting magnetic fine particle systems is a long standing and difficult inverse problem. As an example, the Switching Field Distribution (SFD) is an important quantity in the characterization of magnetic systems, and its determination in many technological applications, such as recording media, is especially challenging. Techniques such as the first order reversal curve (FORC) methods, were developed to extract the SFD from macroscopic measurements. However, all methods rely on separating the contributions to the measurements of the intrinsic SFD and the extrinsic effects of magnetostatic and exchange interactions. We investigate the underlying physics of the FORC method by applying it to the output predictions of a kinetic Monte-Carlo model with known input parameters. We show that the FORC method is valid only in cases of weak spatial correlation of the magnetisation and suggest a more general approach
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