3-Chloro-6-{4-[3-(trifluoro­meth­yl)phen­yl]piperazin-1-yl}pyridazine

The title compound, C15H14ClF3N4, was synthesized from 3,6-dichloro­pyridazine and 1-[3-(trifluoro­meth­yl)phen­yl]piper­azine. The piperazine ring is flanked by 3-chloro­pyridazine and 3-trifluoro­methyl­phenyl rings and adopts a chair conformation, whereas the 3-chloro­pyridazine and 3-trifluoro­methyl­phenyl rings are planar, with maximum deviations of 0.0069 (13) and 0.0133 (14) Å, respectively. The crystal structure is stabilized by weak inter­molecular C—H⋯N hydrogen-bond inter­actions

Using guarding net to reduce regularly discarded invertebrates in trammel net fisheries operating on seagrass meadows (Posidonia oceanica) in Izmir Bay (Eastern Aegean Sea)

Prohibition of both beach and boat seines and trawl fishery along the İzmir Bay coasts in the Aegean Sea signifies intensive usage of gillnets and trammel nets, for catching red mullet (Mullus spp.) species in particular. Trials were realized between March 2009 and February 2010 with trammel nets in the areas on the boundaries of the sea grass (Posidonia oceanica) meadows in the Bay. Guarding net (selvedge) was attached to the lead line of experimental nets (Exp1-Exp2) - 36 and 40 mm inner panel. Differences for discard amounts between control group nets (C1-C2) (having the same inner panel as the experimental nets), used by commercial fishermen, and experimental nets are 54.7% for C1-Exp1 and 62.8% for C2-Exp2 (p<0.05). Use of nets with selvedge not only reduced regularly discarded invertebrates (Hexaplex trunculus, Bolinus brandaris, Maja spp.) in the region, but also avoided net damage caused by these species

Thermal and residual stress anlayses of a welded stainless steel plate

Paper presented at the 9th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Malta, 16-18 July, 2012.In this study, a welding simulation was analyzed numerically by using finite element method. Two-dimensional model of butt welded plate was conducted in ANSYS finite element package software. Transient thermal distribution on ST-37 plate was obtained for all time intervals until it reaches environment temperature. The initial temperature of ST-37 was considered 300 K, whilst the temperature of welded zone was assumed to be 1773 K. The enthalpy and density of the welded zone material were assumed to have temperature dependent values, although the non-welded zone of the steel was considered to have constant values. In accordance to this, plastic stresses were presented base on the elasto-plastic bilinear material behavior using structural analysis. Finally, residual stresses were found out by removing loads on the butt welded plate. Changing of residual stresses and spread of plastic zones according to cooling time were investigated.dc201

Effects of Prolonged Intravenous Flunixin Meglumine in Healthy Dogs

This study was designed to evaluate possible side effects on liver and kidney functions and haematological indices, associated with long-term intravenous (IV) administration of flunixin meglumine in healthy dogs. For this purpose, 12 dogs were divided into 2 equal groups. Group 1 was intravenously given flunixin meglumine at the dose of 1.1 mg/kg/day for 5 days and g-roup 11 received 2.2 mg/kg/day IV for 5 days. Blood samples were withdrawn before treatment (day 0), 2 h post injection on each day of treatment and one day after the last injection for biochemical (glucose, sodium-Na, potassium-K, chloride-Cl, creatinine, urea, alkaline phosphatase-AP, alanine amino transferase-ALT and total protein) and haematological (bleeding time, coagulation time, red blood cell, white blood cell, platelet count, differential leukocyte count, haematocrit and haemoglobin) analyses. Faecal and urine samples were collected on the same days as blood samples for the presence of any abnormalities. The results revealed a significant increase in bleeding (P < 0.001) and coagulation time (P < 0.001) and a decrease in platelet count (P < 0.001) in both groups. There was also a significant increase in the concentration of Na and Cl in group 1 and an elevation in AP (P < 0.00 07 ALT (P < 0.001) and glucose (P < 0.001) in group II. Blood in urine and faeces was also evident in both groups. The results may suggest that the dose of 1.1 mg/kg IV for 5 d does not cause any significant side effects provided that no bleeding disorder exists. and the dose of 2.2 mg/kg IV for 5 d should not exceed 3 d as liver enzymes began to increase significantly afterwards

Diabetic Foot Due to Anaphylactic Shock: A Case Report

Introduction: Diabetic foot is a clinical disorder, which is commonly seen in patients with diabetes mellitus. It is also the major cause of below knee amputation in the world. There are many underlying causes such as neuropathic, ischemic, and infectious causes for diabetic foot. Local or systemic complications may develop after snake bite. Case Presentation: We reported a very rare case, involving a 78-year-old male admitted to the Emergency Department, who developed anaphylactic shock and diabetic foot after the snake bite. Conclusions: Reviewing the literature, this is the second reported case of snake bite associated with diabetic foot

ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion

The severe‐acute‐respiratory‐syndrome‐coronavirus‐2 (SARS‐CoV‐2) is the causative agent of COVID‐19, but host cell factors contributing to COVID‐19 pathogenesis remain only partly understood. We identify the host metalloprotease ADAM17 as a facilitator of SARS‐CoV‐2 cell entry and the metalloprotease ADAM10 as a host factor required for lung cell syncytia formation, a hallmark of COVID‐19 pathology. ADAM10 and ADAM17, which are broadly expressed in the human lung, cleave the SARS‐CoV‐2 spike protein (S) in vitro, indicating that ADAM10 and ADAM17 contribute to the priming of S, an essential step for viral entry and cell fusion. ADAM protease‐targeted inhibitors severely impair lung cell infection by the SARS‐CoV‐2 variants of concern alpha, beta, delta, and omicron and also reduce SARS‐CoV‐2 infection of primary human lung cells in a TMPRSS2 protease‐independent manner. Our study establishes ADAM10 and ADAM17 as host cell factors for viral entry and syncytia formation and defines both proteases as potential targets for antiviral drug development

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns