The Daya Bay and T2K results on sin22\u3b813 and non-standard neutrino interactions

We show that the relatively large best fit value of sin^22\u3b813=0.14(0.17) measured in the T2K experiment for fixed values of i) the Dirac CP violation phase \u3b4=0, and ii) the atmospheric neutrino mixing parameters \u3b8(23)=\u3c0/4, |\u394m^2(32)|=2.4 710^{ 123} eV^2, can be reconciled with the Daya Bay result sin^22\u3b8(13)=0.090\ub10.009 if the effects of non-standard neutrino interactions (NSI) in the relevant \u3bd\uafe\u2192\u3bd\uafe and \u3bd\u3bc\u2192\u3bde oscillation probabilities are taken into account. \ua9 2014 The Authors

Percutaneous treatment with Mitraclip for functional mitral regurgitation: medium-term follow up according to left ventricular function

Background: Functional mitral regurgitation (FMR) is a bad prognosis condition despite optimal medical treatment. Nowadays there is an open debate about the surgical versus percutaneous treatment. The main objective of this study is to evaluate the mid-term follow up clinical outcomes of patients with FMR treated with MitraClip((R)) system, according to their left ventricular ejection fraction (LVEF). Methods: Data was obtained from two experienced centers in transcatheter mitral valve repair (TMVR). All consecutive cases of severe FMR undergoing TMVR in both centers with the same inclusion criteria were included prospectively in this study and followed-up. Periodical follow-ups with clinical and echocardiographic evaluation were scheduled from the baseline procedure, at 3 months and then yearly. Results: From October 2015 to October 2019, a total of 119 patients with FMR at 2 centers in Spain underwent TMVR with the MitraClip((R)) procedure and were included in this study. The mean age was 73.8+/-8.9 years old and 32 patients (26.9%) were female. A 39.5% of cases [47] had a LVEF 30% (group 2). There was a similar distribution in cardiovascular risk factors, age and other diseases. All MitraClip((R)) implantations were elective and procedural success was achieved in 110 patients (92.4%) with a similar distribution between the groups. There were no differences in procedural time and the number of implanted clips. The median follow-up was 22.6 months (IQR, 11.43-34.98 months). The primary combined endpoint occurred in the 41.6% of the global cohort, 57.5% in group 1 and 30.99% in group 2 (P=0.036). LVEF was associated to the main event in the multivariate analysis (HR 2.09, 95% CI: 1.12-3.89; P=0.02). Conclusions: The MitraClip edge-to-edge technique is a safe and effective procedure for the treatment of FMR. In this study, patients with LVEF >30% treated with Mitraclip presented better clinical cardiovascular outcomes than those with a LVEF </=30%. Regardless clinical outcomes, at the end of the follow-up, there was a sustained reduction in MR grades and an important improvement in NYHA functional class

Mutational Analyses of the Influenza A Virus Polymerase Subunit PA Reveal Distinct Functions Related and Unrelated to RNA Polymerase Activity

Influenza A viral polymerase is a heterotrimeric complex that consists of PA, PB1, and PB2 subunits. We previously reported that a di-codon substitution mutation (G507A-R508A), denoted J10, in the C-terminal half of PA had no apparent effect on viral RNA synthesis but prevented infectious virus production, indicating that PA may have a novel role independent of its polymerase activity. To further examine the roles of PA in the viral life cycle, we have now generated and characterized additional mutations in regions flanking the J10 site from residues 497 to 518. All tested di-codon mutations completely abolished or significantly reduced viral infectivity, but they did so through disparate mechanisms. Several showed effects resembling those of J10, in that the mutant polymerase supported normal levels of viral RNA synthesis but nonetheless failed to generate infectious viral particles. Others eliminated polymerase activity, in most cases by perturbing the normal nuclear localization of PA protein in cells. We also engineered single-codon mutations that were predicted to pack near the J10 site in the crystal structure of PA, and found that altering residues K378 or D478 each produced a J10-like phenotype. In further studies of J10 itself, we found that this mutation does not affect the formation and release of virion-like particles per se, but instead impairs the ability of those particles to incorporate each of the eight essential RNA segments (vRNAs) that make up the viral genome. Taken together, our analysis identifies mutations in the C-terminal region of PA that differentially affect at least three distinct activities: protein nuclear localization, viral RNA synthesis, and a trans-acting function that is required for efficient packaging of all eight vRNAs

Determining the Dirac CP Violation Phase in the Neutrino Mixing Matrix from Sum Rules

Using the fact that the neutrino mixing matrix $U = U^\dagger_{e}U_{\nu}$, where $U_{e}$ and $U_{\nu}$ result from the diagonalisation of the charged lepton and neutrino mass matrices, we analyse the sum rules which the Dirac phase $\delta$ present in $U$ satisfies when $U_{\nu}$ has a form dictated by, or associated with, discrete symmetries and $U_e$ has a ``minimal'' form (in terms of angles and phases it contains) that can provide the requisite corrections to $U_{\nu}$, so that reactor, atmospheric and solar neutrino mixing angles $\theta_{13}$, $\theta_{23}$ and $\theta_{12}$ have values compatible with the current data. The following symmetry forms are considered: i) tri-bimaximal (TBM), ii) bimaximal (BM) (or corresponding to the conservation of the lepton charge $L' = L_e - L_\mu - L_{\tau}$ (LC)), iii) golden ratio type A (GRA), iv) golden ratio type B (GRB), and v) hexagonal (HG). We investigate the predictions for $\delta$ in the cases of TBM, BM (LC), GRA, GRB and HG forms using the exact and the leading order sum rules for $\cos\delta$ proposed in the literature, taking into account also the uncertainties in the measured values of $\sin^2\theta_{12}$, $\sin^2\theta_{23}$ and $\sin^2\theta_{13}$. This allows us, in particular, to assess the accuracy of the predictions for $\cos\delta$ based on the leading order sum rules and its dependence on the values of the indicated neutrino mixing parameters when the latter are varied in their respective 3$\sigma$ experimentally allowed ranges

Predictions for the Leptonic Dirac CP Violation Phase: a Systematic Phenomenological Analysis

We derive predictions for the Dirac phase $\delta$ present in the $3\times 3$ unitary neutrino mixing matrix $U = U_e^{\dagger} \, U_{\nu}$, where $U_e$ and $U_{\nu}$ are $3\times 3$ unitary matrices which arise from the diagonalisation respectively of the charged lepton and the neutrino mass matrices. We consider forms of $U_e$ and $U_{\nu}$ allowing us to express $\delta$ as a function of three neutrino mixing angles, present in $U$, and the angles contained in $U_{\nu}$. We consider several forms of $U_{\nu}$ determined by, or associated with, symmetries, tri-bimaximal, bimaximal, etc., for which the angles in $U_{\nu}$ are fixed. For each of these forms and forms of $U_e$ allowing to reproduce the measured values of the neutrino mixing angles, we construct the likelihood function for $\cos \delta$, using i) the latest results of the global fit analysis of neutrino oscillation data, and ii) the prospective sensitivities on the neutrino mixing angles. Our results, in particular, confirm the conclusion reached in earlier similar studies that the measurement of the Dirac phase in the neutrino mixing matrix, together with an improvement of the precision on the mixing angles, can provide unique information about the possible existence of symmetry in the lepton sector

Increased Terpenoid Accumulation in Cotton (Gossypium hirsutum) Foliage is a General Wound Response

The subepidermal pigment glands of cotton accumulate a variety of terpenoid products, including monoterpenes, sesquiterpenes, and terpenoid aldehydes that can act as feeding deterrents against a number of insect herbivore species. We compared the effect of herbivory by Spodoptera littoralis caterpillars, mechanical damage by a fabric pattern wheel, and the application of jasmonic acid on levels of the major representatives of the three structural classes of terpenoids in the leaf foliage of 4-week-old Gossypium hirsutum plants. Terpenoid levels increased successively from control to mechanical damage, herbivory, and jasmonic acid treatments, with E-β-ocimene and heliocide H1 and H4 showing the highest increases, up to 15-fold. Herbivory or mechanical damage to older leaves led to terpenoid increases in younger leaves. Leaf-by-leaf analysis of terpenes and gland density revealed that higher levels of terpenoids were achieved by two mechanisms: (1) increased filling of existing glands with terpenoids and (2) the production of additional glands, which were found to be dependent on damage intensity. As the relative response of individual terpenoids did not differ substantially among herbivore, mechanical damage, and jasmonic acid treatments, the induction of terpenoids in cotton foliage appears to represent a non-specific wound response mediated by jasmonic acid

Feebly-interacting particles: FIPs 2022 Workshop Report

Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs