Serratia osteomyelitis and chronic granulomatous disease

Chronic Granulomatous Disease (CGD) is a primary immunodeficiency disorder characterized by recurrent purulent infections of the skin, lungs, and reticuloendothelial organs, primarily due to staphylococci, enteric bacteria, fungi, and occasionally mycobacteria. More than two thirds of all cases are X-linked and result from defects in the CYBB gene that encodes the gp91-phox subunit of NADPH oxidase. The authors present a case of a three month old child admitted with a metacarpic steomyelitis by Serratia marcescens. Studies confirmed an abnormal respiratory burst in activated neutrophils and absence of gp91-phox expression on patient and a brother (with previous Nocardia infection). Both hemizygous for a pathogenic mutation detected in exon 3 of CYBB gene (c.252 G>A, p.Ala84Ala), a variant that affects the splicing. At two years of age he is still on prophylaxis with cotrimoxazol and itraconazol, without relevant complications. CGD is rare but must be evocated in cases of uncommon or atypical infections

The Karyotype of the parasitoid Chelonus insularis cresson (Hymenoptera, braconidae, cheloninae).

The Karyotype of chelonus insularis (Hymenoptera, Braconidae Cheloninae) is described. The males show an haploid number of seven chromosomes and the females a diploid number of fourteen chromosomes, confirming haplo-diploid sex determination. Comparisons of these results with karyotypes of other species of the same family were done and a possible mechanism involved in the karyotype evolution of this species is discussed

Analysis of the clonal diversity of Staphylococcus aureus methicillin-resistant strains isolated at João Pessoa, state of Paraíba, Brazil

To investigate the clonal diversity of Staphylococcus aureus strains isolated at João Pessoa, State of Paraíba, Brazil, digested genomic DNA were studied by pulsed-field gel electrophoresis (PFGE) in nine methicillin-resistant strains (MRSA) and three methicillin-sensitive strains (MSSA), selected among 67 isolates based on their antimicrobial susceptibility and epidemiology. The isolates were obtained between April and November 1992 from the Hospital of the Federal University of Paraíba, located in João Pessoa. Two MRSA isolates from the Oswaldo Cruz Hospital, São Paulo, Brazil, including an epidemic strain previously detected from different hospitals at the country were used as control. Five different patterns, were demonstrated by MRSA isolated in João Pessoa and these patterns were described in several epidemiologically unrelated hospitals in São Paulo. Our results suggest the interstate dissemination of a MRSA clone in João Pessoa which is similar to that described in other cities of Brazil.UFPb Departamento de Ciências FarmacêuticasEscola Paulista de Medicina Disciplina de Doenças Infecciosas e ParasitáriasUniversidade Federal do Rio de Janeiro, nstituto de MicrobiologiaUNIFESP, EPM, Disciplina de Doenças Infecciosas e ParasitáriasSciEL

Hypercalcemic crisis associated with primary hyperparathyroidism during pregnancy

Primary hyperparathyroidism is a rare occurrence in pregnancy with significant risks to the mother and the foetus, witch is related to the level of serum calcium. A 41-year-old women, gravida 2, para 1, presented at 22 weeks gestation with nausea, vomiting and mild cognitive dysfunction associated with hypercalcemic crisis. The hypercalcemia was observed to be related to parathyroid hyperplasia that was surgically removed. Complete resolution of her symptomatology and hypercalcemia occurred postoperatively. The pregnancy was complicated with transient hypertension. A small for gestational age healthy male infant was delivered at term with no neonatal complications related with this pathology

Atividade da B-glucosidase em solo natural e artificial com aplicação de biochar.

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Preferência de oviposição por Ceratitis capitata wied. (Diptera: Tephritidae) em diferentes variedades de uva de mesa.

A escolha do hospedeiro para oviposição é de extrema importância no ciclo de vida das moscas-das-frutas, visto que o desenvolvimento dos estágios imaturos, assim como a sobrevivência e a fecundidade dos adultos dependem da fruta hospedeira selecionada.Resumo 1320-1