44 research outputs found
Effects of awareness and task relevance on neurocomputational models of mismatch negativity generation
Detection of regularities and their violations in sensory input is key to perception. Violations are indexed by an early EEG component called the mismatch negativity (MMN) – even if participants are distracted or unaware of the stimuli. On a mechanistic level, two dominant models have been suggested to contribute to the MMN: adaptation and prediction. Whether and how context conditions, such as awareness and task relevance, modulate the mechanisms of MMN generation is unknown. We conducted an EEG study disentangling influences of task relevance and awareness on the visual MMN. Then, we estimated different computational models for the generation of single-trial amplitudes in the MMN time window. Amplitudes were best explained by a prediction error model when stimuli were task-relevant but by an adaptation model when task-irrelevant and unaware. Thus, mismatch generation does not rely on one predominant mechanism but mechanisms vary with task relevance of s
Effects of awareness and task relevance on neurocomputational models of mismatch negativity generation
Detection of regularities and their violations in sensory input is key to perception. Violations are indexed by an early EEG component called the mismatch negativity (MMN) – even if participants are distracted or unaware of the stimuli. On a mechanistic level, two dominant models have been suggested to contribute to the MMN: adaptation and prediction. Whether and how context conditions, such as awareness and task relevance, modulate the mechanisms of MMN generation is unknown. We conducted an EEG study disentangling influences of task relevance and awareness on the visual MMN. Then, we estimated different computational models for the generation of single-trial amplitudes in the MMN time window. Amplitudes were best explained by a prediction error model when stimuli were task-relevant but by an adaptation model when task-irrelevant and unaware. Thus, mismatch generation does not rely on one predominant mechanism but mechanisms vary with task relevance of stimuli
Origins Of Heterospory And The Seed Habit: The Role Of Heterochrony
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149713/1/tax04577.pd
Neuro-cognitive mechanisms of conscious and unconscious visual perception: From a plethora of phenomena to general principles
Psychological and neuroscience approaches have promoted much progress in
elucidating the cognitive and neural mechanisms that underlie phenomenal visual
awareness during the last decades. In this article, we provide an overview of
the latest research investigating important phenomena in conscious and
unconscious vision. We identify general principles to characterize conscious and
unconscious visual perception, which may serve as important building blocks for
a unified model to explain the plethora of findings. We argue that in particular
the integration of principles from both conscious and unconscious vision is
advantageous and provides critical constraints for developing adequate
theoretical models. Based on the principles identified in our review, we outline
essential components of a unified model of conscious and unconscious visual
perception. We propose that awareness refers to consolidated
visual representations, which are accessible to the entire brain and therefore
globally available. However, visual awareness not only depends
on consolidation within the visual system, but is additionally the result of a
post-sensory gating process, which is mediated by higher-level cognitive control
mechanisms. We further propose that amplification of visual representations by
attentional sensitization is not exclusive to the domain of conscious
perception, but also applies to visual stimuli, which remain unconscious.
Conscious and unconscious processing modes are highly interdependent with
influences in both directions. We therefore argue that exactly this
interdependence renders a unified model of conscious and unconscious visual
perception valuable. Computational modeling jointly with focused experimental
research could lead to a better understanding of the plethora of empirical
phenomena in consciousness research
Tackling antibiotic resistance: the environmental framework
Antibiotic resistance is a threat to human and animal health worldwide, and key measures are required to reduce the risks posed by antibiotic resistance genes that occur in the environment. These measures include the identification of critical points of control, the development of reliable surveillance and risk assessment procedures, and the implementation of technological solutions that can prevent environmental contamination with antibiotic resistant bacteria and genes. In this Opinion article, we discuss the main knowledge gaps, the future research needs and the policy and management options that should be prioritized to tackle antibiotic resistance in the environment
Effects of awareness and task relevance on neurocomputational models of mismatch negativity generation
Detection of regularities and their violations in sensory input is key to perception. Violations are indexed by an early EEG component called the mismatch negativity (MMN) – even if participants are distracted or unaware of the stimuli. On a mechanistic level, two dominant models have been suggested to contribute to the MMN: adaptation and prediction. Whether and how context conditions, such as awareness and task relevance, modulate the mechanisms of MMN generation is unknown. We conducted an EEG study disentangling influences of task relevance and awareness on the visual MMN. Then, we estimated different computational models for the generation of single-trial amplitudes in the MMN time window. Amplitudes were best explained by a prediction error model when stimuli were task-relevant but by an adaptation model when task-irrelevant and unaware. Thus, mismatch generation does not rely on one predominant mechanism but mechanisms vary with task relevance of stimuli
Differential effects of prediction error and adaptation along the auditory cortical hierarchy during deviance processing
Neural mismatch responses have been proposed to rely on different mechanisms, including prediction error-related activity and adaptation to frequent stimuli. However, the hierarchical cortical structure of these mechanisms is unknown. To investigate this question, we recorded hemodynamic responses while participants (N = 54) listened to an auditory oddball sequence as well as a suited control condition. In addition to effects in sensory processing areas (Heschl's gyrus, superior temporal gyrus (STG)), we found several distinct clusters that indexed deviance processing in frontal and parietal regions (anterior cingulate cortex/supplementary motor area (ACC/SMA), inferior parietal lobule (IPL), anterior insula (AI), inferior frontal junction (IFJ)). Comparing responses to the control stimulus with the deviant and standard enabled us to delineate the contributions of prediction error- or adaptation-related brain activation, respectively. We observed significant effects of adaptation in Heschl's gyrus, STG and ACC/SMA, while prediction error-related activity was observed in STG, IPL, AI and IFJ. Additional dynamic causal modeling confirmed the superiority of a hierarchical processing structure compared to a flat structure. Thus, we found that while prediction-error related processes increased with the hierarchical level of the brain area, adaptation declined. This suggests that the relative contribution of different mechanisms in deviance processing varies across the cortical hierarchy