Acute acquired immune thrombocytopenia after cardiac surgery: A challenging case

Thrombocytopenia is a common condition that recognizes an infinite number of possible causes, especially in specific settings like the one covered in this case report: the postoperative period of cardiac surgery. We report a case of an old male with multiple comorbidities who underwent a coronary angioplasty procedure and aortic valve replacement. He showed severe thrombocytopenia in the postoperative days. Differential diagnosis required a big effort, also for the experts in the field. Our goal was to aggressively treat the patient with prednisolone, platelets, and intravenous immunoglobulins to maximize the prognosis. Our patient developed no complications and was discharged successfully

Evolution and Classification of Myosins, a Paneukaryotic Whole-Genome Approach

notes: PubMed ID: 24443438© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.Myosins are key components of the eukaryotic cytoskeleton, providing motility for a broad diversity of cargoes. Therefore, understanding the origin and evolutionary history of myosin classes is crucial to address the evolution of eukaryote cell biology. Here, we revise the classification of myosins using an updated taxon sampling that includes newly or recently sequenced genomes and transcriptomes from key taxa. We performed a survey of eukaryotic genomes and phylogenetic analyses of the myosin gene family, reconstructing the myosin toolkit at different key nodes in the eukaryotic tree of life. We also identified the phylogenetic distribution of myosin diversity in terms of number of genes, associated protein domains and number of classes in each taxa. Our analyses show that new classes (i.e., paralogs) and domain architectures were continuously generated throughout eukaryote evolution, with a significant expansion of myosin abundance and domain architectural diversity at the stem of Holozoa, predating the origin of animal multicellularity. Indeed, single-celled holozoans have the most complex myosin complement among eukaryotes, with paralogs of most myosins previously considered animal specific. We recover a dynamic evolutionary history, with several lineage-specific expansions (e.g., the myosin III-like gene family diversification in choanoflagellates), convergence in protein domain architectures (e.g., fungal and animal chitin synthase myosins), and important secondary losses. Overall, our evolutionary scheme demonstrates that the ancestral eukaryote likely had a complex myosin repertoire that included six genes with different protein domain architectures. Finally, we provide an integrative and robust classification, useful for future genomic and functional studies on this crucial eukaryotic gene family.LeverhulmeBBSRCERCMINECONERCGordon and Betty Moore Foundatio

Fluctuating magnetic moments in liquid metals

We re-analyze literature data on neutron scattering by liquid metals to show that non-magnetic liquid metals possess a magnetic moment that fluctuates on a picosecond time scale. This time scale follows the motion of the cage-diffusion process in which an ion rattles around in the cage formed by its neighbors. We find that these fluctuating magnetic moments are present in liquid Hg, Al, Ga and Pb, and possibly also in the alkali metals.Comment: 17 pages, 5 figures, submitted to PR

Evaluation and modelling of the environmental performance of archival boxes, part 1: material and environmental assessment

Archival boxes are used as a preventive measure to control the microenvironment in museums and archives storages. However, their efficiency in protecting valuable artefacts from fluctuations in relative humidity (RH) is not yet fully understood. In this study, the environmental performance of different archival boxes with different configurations (size, design, presence of holes/paper material, cardboard types, surface modification) was included in the evaluation of internal environment (RH). The effectiveness of archival boxes on reducing relative humidity fluctuations was investigated by testing various properties of boxes and boards, such as air exchange rates (AER), moisture sorption and water vapour transmission rates (WVTR). While most cardboard boxes showed only a limited buffering against the humidity ingress, strategies such as surface modification limited the interaction of a box with the external environment, resulting in a more stable internal environment. Material and box properties, such as moisture sorption, AER and WVTR proved to be useful quantitative tools for assessing the environmental performance of the selected archival boxes

Estudio experimental y numérico de una pared solar en clima templado

CIES2020 - XVII Congresso Ibérico e XIII Congresso Ibero-americano de Energia SolarRESUMEN: Las paredes solares se utilizan desde épocas remotas y en lugares donde el clima presenta una considerable amplitud térmica. Hoy se utilizan incluso para ventilación en veranos de climas templados. Sin embargo, hay pocos estudios sobre el uso de esta tecnología en climas templados o húmedos. En este trabajo se realiza un estudio experimental y numérico de un cuarto de ensayo en Uruguay con un muro acumulador de energía solar orientado al ecuador, para diferentes configuraciones de sombreado del muro con una persiana programable. Se ajustan los parámetros del sistema logrando una buena concordancia entre los datos experimentales y un modelo numérico en el programa EnergyPlus. Además, se analiza el intercambio de energía del muro con la habitación en función de la apertura o no de la persiana.ABSTRACT: Solar walls have been used since ancient times and in places where the climate has a considerable thermal amplitude. Today solar walls are also used for ventilation in summers of temperate climates. However, there are few studies on the use of this technology in temperate or humid climates. In this work, an experimental and numerical study of a test room in Uruguay is carried out with a solar energy accumulator wall facing to the equator, for different shading configurations of the wall with a blind. The system parameters were adjusted achieving a good agreement between the experimental data and the numerical model in the EnergyPlus software. In addition, the energy exchange of the wall with the room is analyzed depending on the opening or not of the blind.info:eu-repo/semantics/publishedVersio

Botulinum toxin type a reconstituted with lidocaine: A report of 1000 consecutive cases

(1) Background: There is an increasing demand for a reversal of the aging process and, nowadays, more patients are seeking minimally invasive methods instead of surgery to meet this goal. The purpose of this paper is to evaluate the predictability of the off-label aesthetic use of botulinum toxin type A (BoNTA) reconstituted with lidocaine. (2) Methods: One thousand treatments, between January 2010 and January 2020, with BoNTA reconstituted with lidocaine for the rejuvenation of the upper third of the face, were performed and retrospectively evaluated. (3) Results: A few seconds after the BoNTA injections, the effect of muscle paralysis was seen in all cases; this allowed providing an optimal symmetric result with no need for a touch-up procedure at the control after three weeks. A burning sensation during the injections was claimed by almost all patients. Major complications were not registered. No touch-up procedures were required. (4) Conclusions: The results of this study show how the reconstitution of BoNTA with lidocaine may avoid imperfect results after the injections; the immediate feedback on the extent of paralysis to be expected from the chemodenervation action of BoNTA allows the physician to have immediate control of the final result

Tachycardia Related Cardiomyopathy: Response to Control of the Arrhythmia

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75609/1/j.1540-8183.1989.tb00780.x.pd