63 research outputs found
Wage inequality, segregation by skill and the price of capital in an assignment model
Some pieces of empirical evidence suggest that in the U.S., over the last few decades, (i) wage inequality between-plants has risen much more than wage inequality within-plants and (ii) there has been an increase in the segregation of workers by skill into separate plants. This paper presents a frictionless assignment model in which these two features can be explained simultaneously as the result of the decline in the relative price of capital. Additional implications of the model regarding the skill premium and the dispersion in labor productivity across plants are also consistent with the empirical evidence. [resumen de autor
Survival transcriptome in the coenzyme Q10 deficiency syndrome is acquired by epigenetic modifications: a modelling study for human coenzyme Q10 deficiencies.
Objectives:Coenzyme Q10(CoQ10) deficiency
syndrome is a rare condition that causes mitochondrial
dysfunction and includes a variety of clinical
presentations as encephalomyopathy, ataxia and renal
failure. First, we sought to set up what all have in
common, and then investigate why CoQ10
supplementation reverses the bioenergetics alterations
in cultured cells but not all the cellular phenotypes.
Design Modelling study:This work models the
transcriptome of human CoQ10deficiency syndrome in
primary fibroblast from patients and study the genetic
response to CoQ10treatment in these cells.
Setting:Four hospitals and medical centres from
Spain, Italy and the USA, and two research laboratories
from Spain and the USA.
Participants:Primary cells were collected from
patients in the above centres.
Measurements:We characterised by microarray
analysis the expression profile of fibroblasts from
seven CoQ10-deficient patients (three had primary
deficiency and four had a secondary form) and aged-matched controls, before and after CoQ10
supplementation. Results were validated by Q-RT-PCR.
The profile of DNA (CpG) methylation was evaluated
for a subset of gene with displayed altered expression.
Results:CoQ10-deficient fibroblasts (independently
from the aetiology) showed a common transcriptomic
profile that promotes cell survival by activating cell
cycle and growth, cell stress responses and inhibiting
cell death and immune responses. Energy production
was supported mainly by glycolysis while CoQ10
supplementation restored oxidative phosphorylation.
Expression of genes involved in cell death pathways
was partially restored by treatment, while genes
involved in differentiation, cell cycle and growth were
not affected. Stably demethylated genes were
unaffected by treatment whereas we observed restored
gene expression in either non-methylated genes or
those with an unchanged methylation patter
Consolidating Antitrust Damages in Europe: A Proposal for Standing in Line With Efficient Private Enforcement
A Cartel's Umbrella Effectt and the Right to Claim Damages for Falling under Its Shadow: What Does It Change for the Private Enforcement of EU Competition Law?
The Impact of Alternative Enforcement Procedures Under EC Competition Law on Damages Actions
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