Data and model driven hybrid approach to activity scoring of cyclic pathways

Analysis of large scale -omics data based on a single tool remains inefficient to reveal molecular basis of cellular events. Therefore, data integration from multiple heterogeneous sources is highly desirable and required. In this study, we developed a data- and model-driven hybrid approach to evaluate biological activity of cellular processes. Biological pathway models were taken as graphs and gene scores were transferred through neighbouring nodes of these graphs. An activity score describes the behaviour of a specific biological process was computed by owing of converged gene scores until reaching a target process. Biological pathway model based approach that we describe in this study is a novel approach in which converged scores are calculated for the cellular processes of a cyclic pathway. The convergence of the activity scores for cyclic graphs were demonstrated on the KEGG pathways. © 2011 Springer Science+Business Media B.V

European Vegetation Archive (EVA): An integrated database of European vegetation plots

© 2016 International Association for Vegetation Science. The European Vegetation Archive (EVA) is a centralized database of European vegetation plots developed by the IAVS Working Group European Vegetation Survey. It has been in development since 2012 and first made available for use in research projects in 2014. It stores copies of national and regional vegetation- plot databases on a single software platform. Data storage in EVA does not affect on-going independent development of the contributing databases, which remain the property of the data contributors. EVA uses a prototype of the database management software TURBOVEG 3 developed for joint management of multiple databases that use different species lists. This is facilitated by the SynBioSys Taxon Database, a system of taxon names and concepts used in the individual European databases and their corresponding names on a unified list of European flora. TURBOVEG 3 also includes procedures for handling data requests, selections and provisions according to the approved EVA Data Property and Governance Rules. By 30 June 2015, 61 databases from all European regions have joined EVA, contributing in total 1 027 376 vegetation plots, 82% of them with geographic coordinates, from 57 countries. EVA provides a unique data source for large-scale analyses of European vegetation diversity both for fundamental research and nature conservation applications. Updated information on EVA is available online at http://euroveg.org/eva-database

The frequency of ankylosing spondylitis among patients with familial mediterranean fever and the relationship with M694V mutation

[No abstract available

Plasmapheresis Therapy in Acute Critical Leg Ischemia Associated withCatastrophic Antiphospholipid Syndrome

Antifosfolipid sendromu tekrarlayan arteryel ve venöz trombozlar ile seyreden otoimmun bir hastalıktır. Tedavisinde antiagregan ve antikoagülan ilaçlar kullanılabilir. Bu tedavilere cevap vermeyen ve akut kritik bacak iskemisi ile başvuran antifosfolipid sendromlu olguda plazmaferez tedavisi başarı ile uygulanmıştır. Olgunun sonuçları literatür eşliğinde gözden geçirilmiştir.Antiphospholipid syndrome is an autoimmune disease associated with repetitive thrombosis of both arterial and venous vasculature. Anti-aggregant and anti-coagulant agents can be used in treatment of these thrombosis. This case with antiphospholipid syndrome and acute leg ischemia which was nonresponsive to these treatment modalisties was treated with plasmapheresis successfully. The case is reported and discussed with literature review

Successful management of mad honey intoxication in a pregnant woman

[No abstract available

Comparison of powerpoint and concrete teaching materials in terms of learning efficiency [PowerPoint Ögretim Materyalleri Ile Somut Ögretim Materyallerin Ögrenme Etkililigi Açisindan Karşilaştirilmasi]

The purpose of this study is to compare the 6th grade learning environments of Mathematics courses in which PowerPoint materials and concrete materials are used. More specifically, this research aims to determine whether there is a difference between employing the above mentioned material types in terms of students' learning levels. An experimental model with pretest-posttest comparison group was used and randomly formed three independent groups were compared with respect to learning levels. A total of 92 sixth grade elementary students participated in the study in the 2010-2011 academic year. The concrete teaching materials in the study included number scales and equation models that are specific to mathematics education and materials that are used in daily life such as sugar cube, purse, crackers or screws that are not specific to mathematics education. PowerPoint materials, on the other hand, included representations such as drawing, picture and animation and also presentations involving verbal information. Two tests that are composed of multiple-choice and open-ended questions were administered in order to measure students' learning levels. After 10 hours of instruction, there were statistically significant increases in students' learning in all the three groups. However, no significant difference was found among the groups in terms of their learning levels

Petrochemistry of the south Marmara granitoids, northwest Anatolia, Turkey

Post-collision magmatic rocks are common in the southern portion of the Marmara region (Kapıdağ, Karabiga, Gönen, Yenice, Çan areas) and also on the small islands (Marmara, Avşa, Paşalimanı) in the Sea of Marmara. They are represented mainly by granitic plutons, stocks and sills within Triassic basement rocks. The granitoids have ages between Late Cretaceous and Miocene, but mainly belong to two groups: Eocene in the north and Miocene in the south. The Miocene granitoids have associated volcanic rocks; the Eocene granitoids do not display such associations. They are both granodioritic and granitic in composition, and are metaluminous, calc-alkaline, medium to high-K rocks. Their trace elements patterns are similar to both volcanic-arc and calc-alkaline post-collision intrusions, and the granitoids plot into the volcanic arc granite (VAG) and collision related granite areas (COLG) of discrimination diagrams. The have high 87Sr/86Sr (0.704–0.707) and low 143Nd/144Nd (0.5124–0.5128). During their evolution, the magma was affected by crustal assimilation and fractional crystallization (AFC). Nd and Sr isotopic compositions support an origin of derivation by combined continental crustal AFC from a basaltic parent magma. A slab breakoff model is consistent with the evolution of South Marmara Sea granitoids

A rare case of uterine rupture due to a placental site trophoblastic tumour in the rudimentary horn

[No abstract available