Blood Pressure and Age Are the Main Determinants of Aortic Stiffness

WOS: 000418303200017PubMed ID: 28982100

The role of cardiac biomarkers as predictors of trastuzumab cardiotoxicity in patients with breast cancer

Aim: Identification of patient with increased risk of cardiotoxicity would allow not only prevention and early diagnosis of chemotherapy related cardiotoxicity but also administration of optimal dose and duration of chemotherapy. Materials and methods: Fifty-two women with HER2+ breast cancer treated with trastuzumab were included in this study. Patients were prospectively followed with routine cardiac evaluation. Before and after administration of trastuzumab blood samples for NT-proBNP were also taken. Results: The median age was 48.5 year (range: 26–74). Hypertension and obesity were two most common co-morbidities. The median duration application of trastuzumab was 52 weeks. During median 14.5 (3–33) months follow-up cardiac adverse events occurred in 5 (9.6%) patients and 2 out of 5 was grade III–IV heart failure. Both patients had preserved left ventricular ejection fraction and no symptom of heart failure before trastuzumab but older than 65 years old and had diabetes mellitus and obesity. High level of NT-proBNP (> 300 ng/ml) was observed in both patients and heart failure recovery was not observed. There was statistically significant difference regarding body mass index (p = 0.004) and diabetes mellitus (p = 0.002) between patients with and without cardiotoxicity. Conclusion: Although, cardiac biomarkers still cannot replace routine cardiac monitoring, natriuretic peptides may provide additional tool for detection of patients with high risk of cardiotoxicity and early detection of cardiotoxicity. Key Words: breast cancer, trastuzumab, heart failure, left ventricular dysfunction, natriuretic peptides

Eğitim ve fen edebiyat fakültesi öğrencilerinin AIDS hakkındaki bilgi düzeyleri

Bu çalışma HIV/AIDS açısından risk altında bulunan genç nüfusun AIDS hakkındaki bilgi ve tutumlarının değerlendirilmesi amacıyla yapılmıştır. Araştırma Haziran 2001 tarihinde Pamukkale Üniversitesi Eğitim Fakültesi ile Fen edebiyat Fakültesi öğrencileri üzerinde gerçekleştirilmiştir. Çalışmada 260 kişiye anket uygulanmıştır. AIDS’in en çok homoseksüellerde ve hayat kadınlarında görüldüğü, en önemli bulaşma yollarının cinsel ilişki ve kan yoluyla olduğu ve bu konudaki bilgilerin genellikle basın yoluyla edinildiği belirlenmiştir. AIDS’ten korunma amacıyla yapılması gerekenler arasında korunmalı cinsel ilişki ve kan ürünlerinin verilmeden önce test edilmesinin ve uzun süreli eğitimin gerekli olduğu sonucuna ulaşılmıştır

Photochemical reactions of ?-terpinene and acenaphthene under concentrated sunlight

?-Terpinene was successfully dehydrogenated to p-cymene in photocatalytic reaction with benzophenone and cupric ions under 40 suns concentrated sunlight irradiation, proving that photodehydrogenation reactions may be employed for the synthesis of fine chemicals under sunlight. Acenaphthene dehydrogenation under concentrated sunlight resulted in the minor formation of acenaphthylene and the quantitative formation of acenaphthenone when the solution was aerated. Stable benzylic-type radical intermediates are thought to lower the yield of dehydrogenation reactions

Highly chemoselective thiocarbonyl oxidation upon reaction of 4-methyl-3-phenyl -2-thiazolidinethione with singlet oxygen

4-Methyl-3-phenyl-2-thiazoIidinethione was reacted with both photochemically and chemically generated singlet oxygen. Despite reaction conditions which were selected to favor oxidation of the sulfide group, both reactions afforded a single product arising solely from thiocarbonyl oxidation

Fabrication and Characterization of Spin-coated TiO2 Films

Porous TiO2 films were deposited on glass and ITO coated glass substrates by spin coating for spinning rates of 2000, 5000, 2000 followed by successive run of 5000 rpm (2000-5000). The AFM, SEM, XRD and UV-Vis analysis of the films coated on bare glass substrates for individual and 2000-5000 rpm runs showed amorphous and crystalline behaviours respectively, while TiO2 films deposited on ITO/Glass substrates show crystalline structure. Both substrate nature and thickness of the films influence the formation of the crystallinity of the films. Also AFM images reveal that the roughness values of the films are independent of substrate

Orchiectomy as a result of ischemic orchitis after inguinal hernia repair

Ischemic orchitis is an established complication after open and laparoscopic inguinal hernia repair, but ischemic orchitis resulting in orchiectomy after the surgical approach is very rare. We reported a case of healthy 47 year-old man, with no previous surgery or history of trauma, who presented with right direct inguinal hernia. He is a thin, muscular male with a narrow pelvis who underwent right extraperitoneal mesh implantation with open inguinal hernia repair. The patient was discharged on the same day and doing well with minimal pain and swelling until the fifth day after surgery. That night he presented with sudden-onset of pain and swelling of his right testicle and denied both trauma to the area and any sexual activity. Scintigraphy and ultrasound of the testicle revealed no blood flow to the testicle which required exploration and subsequent orchiectomy

Türkiye’nin sönmeyen ateşi : Kav kibrit

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2014.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Öztürk, İbrahim Mert