On a Theoretical Interpretation of the Period Gap in Binary Millisecond Pulsars

We reexamine evolutionary channels for the formation of binary millisecond pulsars in order to understand their observed orbital period distribution. The available paths provide a natural division into systems characterized by long orbital periods (> 60 d) and short orbital periods (< 30 d). Systems with initial periods 1 - 2 d ultimately produce low mass He white dwarfs with short orbital periods ( few days), early massive Case B evolution produces CO white dwarfs with orbital periods < 20 d. Common envelope evolution result in short period systems (P < 1 d) from unstable low mass Case B evolution producing He white dwarfs, and from unstable Case C evolution leading to CO white dwarfs. On the other hand, the long orbital period group arises from stable low mass Case B evolution with initial periods > few days producing low mass He white dwarfs and periods > 30 d, and from stable Case C evolution producing CO white dwarfs. The lack of observed systems between 23 and 56 days probably reflects the fact that for comparable initial orbital periods (< few days) low mass Case B and early massive Case B evolution lead to very discrepant final periods. We show in particular that the lower limit (~ 23 d) cannot result from common-envelope evolution.Comment: 20 pages, one encapsulated figure, LaTeX, accepted by Ap

Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele

Daily patterns of animal behavior are potentially of vast functional importance. Fitness benefits have been identified in nature by the association between individual timing and survival or by the fate of individuals after experimental deletion of their circadian pacemaker. The recent advances in unraveling the molecular basis of circadian timing enable new approaches to natural selection on timing. The investigators report on the effect and fate of the mutant Per2(Brdm1) allele in 4 replicate populations of house mice in a seminatural outside environment over 2 years. This allele is known to compromise circadian organization and entrainment and to cause multiple physiological disturbances. Mice (N=250) bred from Per2(Brdm1) heterozygotes were implanted subcutaneously with transponders and released in approximately Mendelian ratios in four 400 m(2) pens. An electronic system stored the times of all visits to feeders of each individual. The study first demonstrates that mice are not explicitly nocturnal in this natural environment. Feeding activity was predominantly and sometimes exclusively diurnal and spread nearly equally over day and night under the protective snow cover in winter. The effect of Per2(Brdm1) on activity timing is negligible compared to seasonal changes in all genotypes. Second, the Per2(Brdm1) allele did not have persistent negative effects on fitness. In the first year, the allele gradually became less frequent by reducing survival. New cohorts captured had the same Per2(Brdm1) frequency as the survivors from previous cohorts, consistent with an absence of an effect on reproduction. In the second year, the allele recovered to about its initial frequency (0.54). These changes in selective advantage were primarily due to female mice, as females lived longer and the sex ratio dropped to about 25% males in the population. While it is unknown which selective advantage led to the recovery, the results caution against inferences from laboratory experiments on fitness consequences in the natural environment. It also demonstrates that the activity of mice, while strictly nocturnal in the laboratory, may be partially or completely diurnal in the field. The new method allows assessment of natural selection on specific alleles on a day-today basis

Persistent failures in gene repair

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