Application of Alloy 718 in M-1 engine components

Alloy 718 applied to components of M-1 rocket engin

Remote sensing of atmospheric winds using a coherent, CW lidar and speckle-turbulence interaction

Speckle turbulence interaction has the potential for allowing single ended remote sensing of the path averaged vector crosswind in a plane perpendicular to the line of sight to a target. If a laser transmitter is used to illuminate a target, the resultant speckle field generated by the target is randomly perturbed by the atmospheric turbulence as it propagates back to the location of the transmitter-receiver. When a cross wind is present, this scintillation pattern will move with time across the receiver. A continuous wave (cw) laser transmitter of modest power level in conjunction with optical heterodyne detection was used to exploit the speckel turbulence interaction and measure the crosswind. The use of a cw transmitter at 10.6 microns and optical heterodyne detection has many advantages over direct detection and a double pulsed source in the visible or near infrared. These advantages include the availability of compact, reliable and inexpensive transmitters, better penetration of smoke, dust and fog; stable output power; low beam pointing jitter; and considerably reduced complexity in the receiver electronics

Revertant fibres and dystrophin traces in Duchenne muscular dystrophy: Implication for clinical trials

Duchenne muscular dystrophy (DMD) is characterised by the absence of dystrophin in muscle biopsies, although residual dystrophin can be present, either as dystrophin-positive (revertant) fibres or traces. As restoration of dystrophin expression is the end point of clinical trials, such residual dystrophin is a key factor in recruitment of patients and may also confound the analysis of dystrophin restoration in treated patients, if, as previously observed in the mdx mouse, revertant fibres increase with age. In 62% of the diagnostic biopsies reports of 65 DMD patients studied, traces or revertants were recorded with no correlation between traces or revertants, the patients' performance, or corticosteroids response. In nine of these patients, there was no increase in traces or revertants in biopsies taken a mean of 8.23 years (5.8-10.4 years) after the original diagnostic biopsy. This information should help in the design and execution of clinical trials focused on dystrophin restoration strategies. (C) 2010 Elsevier B.V. All rights reserved

Production, Fate and Pathogenicity of Plasma Microparticles in Murine Cerebral Malaria

In patients with cerebral malaria (CM), higher levels of cell-specific microparticles (MP) correlate with the presence of neurological symptoms. MP are submicron plasma membrane-derived vesicles that express antigens of their cell of origin and phosphatidylserine (PS) on their surface, facilitating their role in coagulation, inflammation and cell adhesion. In this study, the in vivo production, fate and pathogenicity of cell-specific MP during Plasmodium berghei infection of mice were evaluated. Using annexin V, a PS ligand, and flow cytometry, analysis of platelet-free plasma from infected mice with cerebral involvement showed a peak of MP levels at the time of the neurological onset. Phenotypic analyses showed that MP from infected mice were predominantly of platelet, endothelial and erythrocytic origins. To determine the in vivo fate of MP, we adoptively transferred fluorescently labelled MP from mice with CM into healthy or infected recipient mice. MP were quickly cleared following intravenous injection, but microscopic examination revealed arrested MP lining the endothelium of brain vessels of infected, but not healthy, recipient mice. To determine the pathogenicity of MP, we transferred MP from activated endothelial cells into healthy recipient mice and this induced CM-like brain and lung pathology. This study supports a pathogenic role for MP in the aggravation of the neurological lesion and suggests a causal relationship between MP and the development of CM. © 2014 El-Assaad et al

ALMA reveals the feeding of the Seyfert 1 nucleus in NGC 1566

We report ALMA observations of CO(3-2) emission in the Seyfert 1 galaxy NGC 1566, at a spatial resolution of 25 pc. Our aim is to investigate the morphology and dynamics of the gas inside the central kpc, and to probe nuclear fueling and feedback phenomena. NGC 1566 has a nuclear bar of 1.7 kpc radius and a conspicuous grand design spiral starting from this radius. The ALMA field of view, of diameter 0.9 kpc, lies well inside the nuclear bar and reveals a molecular trailing spiral structure from 50 to 300~pc in size, which is contributing to fuel the nucleus, according to its negative gravity torques. The spiral starts with a large pitch angle from the center and then winds up in a pseudo-ring at the inner Lindblad resonance (ILR) of the nuclear bar. This is the first time that a trailing spiral structure is clearly seen driving the gas inwards inside the ILR ring of the nuclear bar. This phenomenon shows that the massive central black hole has a significant dynamical influence on the gas, triggering its fueling. The gaseous spiral is well correlated with the dusty spiral seen through extinction in HST images, and also with a spiral feature emitting 0.87mm continuum. This continuum emission must come essentially from cold dust heated by the interstellar radiation field. The HCN(4-3) and HCO+(4-3) lines were simultaneously mapped and detected in the nuclear spiral. The HCO+(4-3) line is 3 times stronger than the HCN(4-3), as expected when star formation excitation dominates over active galactic nucleus (AGN) heating. The CO(3-2)/HCO+(4-3) integrated intensity ratio is \sim 100. The molecular gas is in remarkably regular rotation, with only slight non-circular motions at the periphery of the nuclear spiral arms. These perturbations are quite small, and no outflow nor AGN feedback is detected.Comment: 11 pages, 16 figures, accepted in Astronomy and Astrophysic

ALMA observations of feeding and feedback in nearby Seyfert galaxies: an AGN-driven outflow in NGC 1433

We report ALMA observations of CO(3-2) emission in the Seyfert 2 double-barred galaxy NGC1433, at the unprecedented spatial resolution of 0.5"=24 pc. Our aim is to probe AGN feeding and feedback phenomena through the morphology and dynamics of the gas inside the central kpc. The CO map, which covers the whole nuclear region (nuclear bar and ring), reveals a nuclear gaseous spiral structure, inside the nuclear ring encircling the nuclear stellar bar. This gaseous spiral is well correlated with the dusty spiral seen in Hubble Space Telescope images. The nuclear spiral winds up in a pseudo-ring at 200 pc radius, which might correspond to the inner ILR. Continuum emission is detected at 0.87 mm only at the very centre, and its origin is more likely thermal dust emission than non-thermal emission from the AGN. It might correspond to the molecular torus expected to exist in this Seyfert 2 galaxy. The HCN(4-3) and HCO+(4-3) lines were observed simultaneously, but only upper limits are derived, with a ratio to the CO(3-2) line lower than 1/60 at 3sigma, indicating a relatively low abundance of very dense gas. The kinematics of the gas over the nuclear disk reveal rather regular rotation only slightly perturbed by streaming motions due to the spiral; the primary and secondary bars are too closely aligned with the galaxy major or minor axis to leave a signature in the projected velocities. Near the nucleus, there is an intense high-velocity CO emission feature redshifted to 200 km/s (if located in the plane), with a blue-shifted counterpart, at 2" (100 pc) from the centre. While the CO spectra are quite narrow in the centre, this wide component is interpreted as an outflow involving a molecular mass of 3.6 10^6 Mo and a flow rate 7 Mo/yr. The flow could be in part driven by the central star formation, but is mainly boosted by the AGN through its wind or radio jets.Comment: 11 pages, 9 figures, Accepted in Astronomy and Astrophysic

Dynamical Friction in a Gaseous Medium

Using time-dependent linear perturbation theory, we evaluate the dynamical friction force on a massive perturber M_p traveling at velocity V through a uniform gaseous medium of density rho_0 and sound speed c_s. This drag force acts in the direction -\hat V, and arises from the gravitational attraction between the perturber and its wake in the ambient medium. For supersonic motion (M=V/c_s>1), the enhanced-density wake is confined to the Mach cone trailing the perturber; for subsonic motion (M<1), the wake is confined to a sphere of radius c_s t centered a distance V t behind the perturber. Inside the wake, surfaces of constant density are hyperboloids or oblate spheroids for supersonic or subsonic perturbers, respectively, with the density maximal nearest the perturber. The dynamical drag force has the form F_df= - I 4\pi (G M_p)^2\rho_0/V^2. We evaluate I analytically; its limits are I\to M^3/3 for M>1. We compare our results to the Chandrasekhar formula for dynamical friction in a collisionless medium, noting that the gaseous drag is generally more efficient when M>1 but less efficient when M<1. To allow simple estimates of orbit evolution in a gaseous protogalaxy or proto-star cluster, we use our formulae to evaluate the decay times of a (supersonic) perturber on a near-circular orbit in an isothermal \rho\propto r^{-2} halo, and of a (subsonic) perturber on a near-circular orbit in a constant-density core. We also mention the relevance of our calculations to protoplanet migration in a circumstellar nebula.Comment: 17 pages, 5 postscript figures, to appear in ApJ 3/1/9

Medical Diagnostic Ultrasound

As early as 250 BCE, captains of ancient Greek ships would drop lead weights overboard to provide an estimate of water depth. They would count until those “sounders” produced an audible thud and in that way measure the propagation time of the falling weight. Even though the practice has given way to other technologies for sounding, one still hears the phrase “to sound something out.” In the 17th century, Isaac Newton became fascinated with sound propagation and was one of the first to describe relationships between the speed of sound and measurable properties of the propagation medium, such as density and pressure. Section 8 of Book 2 of the Principia, for example, is devoted to “the motion propagated through fluids” and includes the proposition that the sound speed is given by the square root of the ratio of the “elastic force” to the density of the medium