Enhanced temporal resolution in femtosecond dynamic-grating experiments

Recording of gratings by interference of two pump pulses and diffraction of a third probe pulse is useful for investigating ultrafast material phenomena. We demonstrate, in theory and experiment, that the temporal resolution in such configurations does not degrade appreciably even for large angular separation between the pump pulses. Transient Kerr gratings are generated inside calcium fluoride (CaF2) crystals by two interfering femtosecond (pump) pulses at 388 nm and read out by a Bragg-matched probe pulse at 776 nm. The solution to the relevant coupled-mode equations is well corroborated by the experimental results, yielding a value of the Kerr coefficient of ~ 4.4×10^(–7) cm^2/GW for CaF2

Survival after an Intentional Ingestion of Crushed Abrus Seeds

Abrus precatorius seeds contain one of the most potent toxins known to man. However, because of the seed’s outer hard coat the vast majority of ingestions cause only mild symptoms and typically results in complete recovery. If the seeds are crushed and then ingested, more serious toxicity, including death, can occur

Femtosecond holography in lithium niobate crystals

Spatial gratings are recorded holographically by two femtosecond pump pulses at 388 nm in lithium niobate (LiNbO3) crystals and read out by a Bragg-matched, temporally delayed probe pulse at 776 nm. We claim, to our knowledge, the first holographic pump-probe experiments with subpicosecond temporal resolution for LiNbO3. An instantaneous grating that is due mostly to the Kerr effect as well as a long-lasting grating that results mainly from the absorption caused by photoexcited carriers was observed. The Kerr coefficient of LiNbO3 for our experimental conditions, i.e., pumped and probed at different wavelengths, was approximately 1.0×10^-5 cm²/GW

The Effects of Chemical Coagulants on the Decolorization of Dyes by Electrocoagulation Using Response Surface Methodology (RSM)

This study assessed the efficiency of electrocoagulation (ECF) coupled with an addition of chemical coagulant to decolorize textile dye. Tests were conducted using Box Behnken methodology to vary six parameters: dye type, weight, coagulant type, dose, initial pH and current density. The combination of electrocoagulation and chemical coagulation was able to decolorize dye up to 99.42 % in 30 min of treatment time which is remarkably shorter in comparison with using conventional chemical coagulation. High color removal was found to be contingent upon the dye type and current density, along with the interactions between the current density and the coagulant dose. The addition of chemical coagulants did enhanced treatment efficiency

Goal-Conditioned End-to-End Visuomotor Control for Versatile Skill Primitives

Visuomotor control (VMC) is an effective means of achieving basic manipulation tasks such as pushing or pick-and-place from raw images. Conditioning VMC on desired goal states is a promising way of achieving versatile skill primitives. However, common conditioning schemes either rely on task-specific fine tuning - e.g. using one-shot imitation learning (IL) - or on sampling approaches using a forward model of scene dynamics i.e. model-predictive control (MPC), leaving deployability and planning horizon severely limited. In this paper we propose a conditioning scheme which avoids these pitfalls by learning the controller and its conditioning in an end-to-end manner. Our model predicts complex action sequences based directly on a dynamic image representation of the robot motion and the distance to a given target observation. In contrast to related works, this enables our approach to efficiently perform complex manipulation tasks from raw image observations without predefined control primitives or test time demonstrations. We report significant improvements in task success over representative MPC and IL baselines. We also demonstrate our model's generalisation capabilities in challenging, unseen tasks featuring visual noise, cluttered scenes and unseen object geometries.Comment: revised manuscript with additional baselines and generalisation experiments; 11 pages, 8 figures, 7 table

A system for genome-wide histone variant dynamics in ES cells reveals dynamic MacroH2A2 replacement at promoters

Dynamic exchange of a subset of nucleosomes in vivo plays important roles in epigenetic inheritance of chromatin states, chromatin insulator function, chromosome folding, and the maintenance of the pluripotent state of embryonic stem cells. Here, we extend a pulse-chase strategy for carrying out genome-wide measurements of histone dynamics to several histone variants in murine embryonic stem cells and somatic tissues, recapitulating expected characteristics of the well characterized H3.3 histone variant. We extended this system to the less-studied MacroH2A2 variant, commonly described as a repressive histone variant whose accumulation in chromatin is thought to fix the epigenetic state of differentiated cells. Unexpectedly, we found that while large intergenic blocks of MacroH2A2 were stably associated with the genome, promoter-associated peaks of MacroH2A2 exhibited relatively rapid exchange dynamics in ES cells, particularly at highly-transcribed genes. Upon differentiation to embryonic fibroblasts, MacroH2A2 was gained primarily in additional long, stably associated blocks across gene-poor regions, while overall turnover at promoters was greatly dampened. Our results reveal unanticipated dynamic behavior of the MacroH2A2 variant in pluripotent cells, and provide a resource for future studies of tissue-specific histone dynamics in vivo

Cocaine-Associated Seizures and Incidence of Status Epilepticus

Objectives: Acute complications from cocaine abuse are commonly treated in the emergency department (ED); one of the most consequential is status epilepticus. The incidence of this complication is not clearly defined in the prior literature on cocaine-associated sequelae. We evaluated the incidence of status epilepticus in patients with seizures secondary to suspected cocaine use.Methods: We performed a retrospective multi-center study of patients with seizures resulting from cocaine use. We identified study subjects at 15 hospitals by record review and conducted a computer-assisted records search to identify patients with seizures for each institution over a four-year period. We selected subjects from this group on the basis of cocaine use and determined the occurrence of status epilepticus among them. Data were collected on each subject using a standardized data collection form.Results: We evaluated 43 patients in the ED for cocaine-associated seizures. Their age range was 17 to 54, with a mean age was 31 years; 53% were male. Of 43 patients, 42 experienced a single tonic-clonic seizure and one developed status epilepticus. All patients had either a history of cocaine use or positive urine drug screen for cocaine.Conclusion: Despite reported cases of status epilepticus with cocaine-induced seizures, the incidence of this complication was unclear based on prior literature. This study shows that most cocaine-associated seizures are self-limited. [West J Emerg Med. 2010; 11(2):157-160.

Determination of location factor on the rental value of business lot in shopping mall using Ordinary Least Squares (OLS) technique

Shopping mall is one of the commercial properties which had a high rental value. This happen because of various factors and one of them is location. In Sabah, there are many shopping malls that have been developed. Among them are Wisma Merdeka, which is one of the oldest shopping malls in Kota Kinabalu city. However, Wisma Merdeka has a relatively high rental value when compared to other shopping complexes around Kota Kinabalu. Therefore, this study aims to identify factors in assessing the rental value by using GIS technology and spatial statistical model. Location factor has always been the main reason influencing the rental value of commercial properties. To get a precise valuation of store rental, it can be determine using the spatial statistics method. This paper aims to study the relationship between the rental value of business lot in a mall and the influence of internal location factor in a mall using Ordinary Least Squares (OLS) technique. OLS technique has been used in this paper where OLS is a multiple regression method that is widely used for viewing the spatial relationship globally. OLS able to show the correlation between the rental value and the variable of location factor through the results of the analysis shown. Furthermore, the network analysis is applied using Geographic Information System (GIS) technology to obtain the business lot distances with the independent variables needed. Among the independent variables studied are the position of the business lot, business lot level, distance from the main entrance, distance from the second entrance, distance from the escalator, distance from the lifting machine, distance from the toilet and the distance from the main tenant. The results show that the position and the placement level of a business lot have a significant effect on the change in rental value with p-value less than 0.05. Meanwhile, other factors such as the distance from the lifts, eskalator, toilets, main entrance, second entrance and distance from the anchor tenant do not show a significant relationship in affecting the rental value at Wisma Merdeka. In conclusion, generally the OLS technique can indicate the influence of location on the rental value of a business lot. However, there are other spatial statistics method can be use for future evaluation purposes

Factors predictive of acute renal failure and need for hemodialysis among ED patients with rhabdomyolysis

Objective: We assessed the primary causes of rhabdomyolysis, the factors associated with the development of acute renal failure (ARF), and the need for hemodialysis (HD) among a series of patients presenting to an urban emergency department with rhabdomyolysis. Methods: A chart review between January 1992 and December 1995 was conducted of patients aged 18 years or older with a diagnosis of rhabdomyolysis and an initial serum creatine phosphokinase greater than 1000 U/L. Patients were excluded if they had evidence of myocardial ischemia, cerebrovascular insufficiency, or the development of rhabdomyolysis after hospitalization. Demographic information, presumed causative factors, past medical history, medication usage, and laboratory data were collected. Results: Ninety-seven patients (93 men, 4 women) were enrolled, with a mean age of 35.7 years. The most common causes of rhabdomyolysis were cocaine (30), exercise (29), and immobilization (18). Seventeen of 97 (17.5%) patients developed ARF; 8 patients (8.25%) needed HD. Several clinical and laboratory factors were statistically associated with development of ARF and need for HD. The only variable that was predictive of both ARF and need for HD in separate multivariate regression models was the initial creatinine (Cr). Initial blood urea nitrogen also was predictive of the need for HD. No patient developed ARF with an initial Cr less than 1.7 mg/dL. Conclusion: Acute renal failure and need for HD are common complications of rhabdomyolysis. Except for initial serum Cr and blood urea nitrogen, clinical and laboratory factors were not reliable predictors for the development of ARF or need for HD.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/40388/1/Fernandez_Factors predictive of acute renal failure_2005.pd