Prioritization of Scientific Sources of Water Information: The Effect Knowledge, Beliefs, and Political Identity

Scientists are reported to be more trusted than other information sources; yet, on essential water facts, people sometimes reject what they perceive water scientists to believe in favor of other belief determinants. This study examines the factors that affect the difference in people\u27s stated willingness to reconsider their water beliefs in response to information provided by scientists relative to information provided by other sources. Regression analysis of responses provided by 806 Florida and Georgia residents found water science knowledge to be a consistently strong influencer of the gap in reliance on scientific information providers relative to other sources. This result is notable given criticisms of the knowledge deficit model. Pre-existing water beliefs had varying levels of influence, and political identity, which might have functioned as a decision heuristic, had little statistically significant effect. The study additionally found water science knowledge and water beliefs to not be strongly related. Higher scores on a water science knowledge assessment were not necessarily an indicator of accurate and knowledge-congruent water beliefs. Moreover, scientific water knowledge and water beliefs had different effects on participants’ reliance on scientific information sources

A Scarcity of Biospheric Values in Local and Regional Reporting of Water Issues: Media Coverage in the Floridan Aquifer Region

The values invoked by journalists in the reporting of water issues influence public support for water policy and the assessment of water tradeoffs. This qualitative framing analysis of water coverage from six newspapers in the Floridan aquifer region from 2010 to 2018 reveals the values used to stimulate reader engagement on a range of water challenges including weather, residential behavior, agriculture, algae, industry, springs, energy, municipalities, and fecal matter. Results reveal a hierarchy of value frames that prioritizes economics and human health, thereby attending primarily to the motivations of egoistic and social-altruistic individuals. The ecosystem implications of deteriorated water conditions, which are of particular interest to biospherically-oriented individuals, received relatively little journalistic attention. This finding suggests that the framing of regional water issues could unintentionally affect reader interest, public prioritization of social goods, and policy interventions

Prediction of tip vortex cavitation inception on marine propellers at an early design stage

The inception of vortex cavitation at an early design stage is still difficult to forecast. The most reliable prediction of the full scale performance is achieved by means of model tests, which are possible for few designs only. A simplified model to calculate the inception of tip vortex cavitation is developed and tested. The model is based on results obtained from potential flow theory, using a boundary element method. The developed tip vortex cavitation inception model and also the panel method are described, after a short introduction to vortex cavitation. The numerical behaviour of the model is investigated for an elliptic wing at different angles of attack and two marine propellers in homogenous and not axially symmetric inflow. The cavitation model s properties concerning different Reynolds numbers are studied and the scale effects on calculated model- and full-scale tip vortices are discussed.http://deepblue.lib.umich.edu/bitstream/2027.42/84317/1/CAV2009-final143.pd

A characterization of products of balls by their isotropy groups

In this paper we will characterize products of balls – especially the ball and the polydisc – in by properties of the isotropy group of a single point. It will be shown that such a characterization is possible in the class of Siegel domains of the second kind, a class that extends the class of bounded homogeneous domains, and that such a characterization is no longer possible in the class of bounded domains with noncompact automorphism groups. The main result is that a Siegel domain of the second kind is biholomorphically equivalent to a product of balls, iff there is a point such that the isotropy group of p contains a torus of dimension n . As an application it will be proved that the only domains biholomorphically equivalent to a Siegel domain of the second kind and to a Reinhardt domain are exactly the domains biholomorphically equivalent to a product of b alls.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41931/1/208-313-4-585_93130585.pd

Prevalence of metabolic syndrome in patients with schizophrenia, and metabolic changes after 3 months of treatment with antipsychotics - results from a German observational study

<p>Abstract</p> <p>Background</p> <p>This observational study explored the prevalence of metabolic syndrome (MetS) in adult in- and outpatients with untreated or treated schizophrenia at baseline, and month-3 after initiation or switch of antipsychotic treatment.</p> <p>Methods</p> <p>MetS-prevalence (AHA/NHLB-definition) was assessed and Clopper-Pearson 95% confidence intervals (CIs) were calculated. Factors associated with MetS were explored through univariate and multivariate logistic regressions (both visits).</p> <p>Results</p> <p>MetS-prevalence was 44.3% (CI 39.8;48.9) at baseline and 49.6% (CI 45.0;54.2) at month-3. Previously unmedicated patients showed the lowest baseline MetS-prevalence (24.7%, CI 18.3;32.1). MetS-prevalence was not significantly different, regardless if patients previously received typical or atypical antipsychotics. Increased MetS-risk was associated with somatic comorbidity and non-smoking at both visits, and with non-psychiatric co-medication, male sex, and increased C-reactive protein at month-3.</p> <p>Conclusions</p> <p>At baseline, MetS was most prevalent in patients with previous antipsychotic medication. Limited metabolic changes were observed 3 months after switch/initiation of antipsychotic therapy.</p> <p>Trial Registration Number</p> <p>ClinicalTrials.gov Identifier: n.a.</p

Acceptor Derivatization of the 4CzIPN TADF System: Color Tuning and Introduction of Functional Groups

We demonstrate modular modifications of the widely employed emitter 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN) by replacing one or both nitrile acceptors with oxadiazole groups via a tetrazole intermediate. This allows the introduction of various functional groups including halides, alkynes, alkenes, nitriles, esters, ethers and a protected amino acid while preserving the thermally activated delayed fluorescence (TADF) properties. The substituents control the emission maximum of the corresponding emitters, ranging between 472–527 nm, and show high solid-state photoluminescence quantum yields up to 85%. The TADF emission of two compounds, 4CzCNOXDtBu and 4CzdOXDtBu, a mono- and a bis-oxadiazole substituted 4CzIPN is characterized in detail by time- and temperaturedependent photoluminescence. Solution-processed OLEDs comprising 4CzCNOXDtBu and 4CzdOXDtBu show a significant blue-shift of the emission compared to the reference 4CzIPN, with external quantum efficiencies of 16%, 5.9% and 17% at 100 cdm⁻², respectively

Acceptor Derivatization of the 4CzIPN TADF System : Color Tuning and Introduction of Functional Groups

We demonstrate modular modifications of the widely employed emitter 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN) by replacing one or both nitrile acceptors with oxadiazole groups via a tetrazole intermediate. This allows the introduction of various functional groups including halides, alkynes, alkenes, nitriles, esters, ethers and a protected amino acid while preserving the thermally activated delayed fluorescence (TADF) properties. The substituents control the emission maximum of the corresponding emitters, ranging between 472-527 nm, and show high solid-state photoluminescence quantum yields up to 85 %. The TADF emission of two compounds, 4CzCNOXDtBu and 4CzdOXDtBu, a mono- and a bis-oxadiazole substituted 4CzIPN is characterized in detail by time- and temperature-dependent photoluminescence. Solution-processed OLEDs comprising 4CzCNOXDtBu and 4CzdOXDtBu show a significant blue-shift of the emission compared to the reference 4CzIPN, with external quantum efficiencies of 16 %, 5.9 % and 17 % at 100 cd m(-2), respectively.Peer reviewe

Biases in comparative analyses of extinction risk: mind the gap

. Comparative analyses are used to address the key question of what makes a species more prone to extinction by exploring the links between vulnerability and intrinsic species’ traits and ⁄ or extrin- sic factors. This approach requires comprehensive species data but information is rarely available for all species of interest. As a result comparative analyses often rely on subsets of relatively few species that are assumed to be representative samples of the overall studied group. 2. Our study challenges this assumption and quantifies the taxonomic, spatial, and data type biases associated with the quantity of data available for 5415 mammalian species using the freely available life-history database PanTHERIA. 3. Moreover, we explore how existing biases influence results of comparative analyses of extinc- tion risk by using subsets of data that attempt to correct for detected biases. In particular, we focus on links between four species’ traits commonly linked to vulnerability (distribution range area, adult body mass, population density and gestation length) and conduct univariate and multivari- ate analyses to understand how biases affect model predictions. 4. Our results show important biases in data availability with c.22% of mammals completely lack- ing data. Missing data, which appear to be not missing at random, occur frequently in all traits (14–99% of cases missing). Data availability is explained by intrinsic traits, with larger mammals occupying bigger range areas being the best studied. Importantly, we find that existing biases affect the results of comparative analyses by overestimating the risk of extinction and changing which traits are identified as important predictors. 5. Our results raise concerns over our ability to draw general conclusions regarding what makes a species more prone to extinction. Missing data represent a prevalent problem in comparative anal- yses, and unfortunately, because data are not missing at random, conventional approaches to fill data gaps, are not valid or present important challenges. These results show the importance of making appropriate inferences from comparative analyses by focusing on the subset of species for which data are available. Ultimately, addressing the data bias problem requires greater investment in data collection and dissemination, as well as the development of methodological approaches to effectively correct existing biases.Peer reviewe

Peripheral blood natural killer cell percentages in granulomatosis with polyangiitis correlate with disease inactivity and stage

Introduction: The role of CD3−CD56+ natural killer (NK) cells in granulomatosis with polyangiitis (GPA) is poorly understood. Recently, it has been shown that peripheral blood NK cells can kill renal microvascular endothelial cells, suggesting a pathogenic role of NK cells in this disease. So far, subset distribution, phenotype, and function of peripheral blood NK cells in relation to GPA disease activity have not been elucidated. Moreover, it is not known whether NK cells infiltrate GPA tissue lesions. Methods: Paraffin sections of GPA granulomas and controls were stained with anti-CD56 and anti-CD3 antibodies. Peripheral blood lymphocyte subsets were analyzed by flow cytometry. NK cell degranulation was analyzed using cocultures of patient PBMCs with target cells and surface expression of CD107a. Clinical data were extracted from medical records. Statistical analysis was performed in an exploratory way. Results: CD56+ cells were not detectable in active granulomatous GPA lesions but were found frequently in granulomas from tuberculosis and sarcoidosis patients. In GPA, the proportion of NK cells among peripheral blood lymphocytes correlated negatively with the Birmingham Vasculitis Activity Score (BVAS) (n = 28). Accordingly, NK cell percentages correlated positively with the duration of remission (n = 28) and were significantly higher in inactive GPA (BVAS = 0, n = 17) than in active GPA, healthy controls (n = 29), and inactive control diseases (n = 12). The highest NK cell percentages were found in patients with long-term remission and tapered immunosuppressive therapy. NK cell percentages >18.5 % of peripheral blood lymphocytes (n = 12/28) determined GPA inactivity with a specificity of 100 %. The differentiation into CD56dim and CD56bright NK cell subsets was unchanged in GPA (n = 28), irrespective of disease activity. Similar surface expression of the activating NK cell-receptors (NKp30, NKp46, and NKG2D) was determined. Like in healthy controls, GPA NK cells degranulated in the presence of NK cell receptor ligand bearing epithelial and lymphatic target cells. Conclusions: NK cells were not detectable in GPA granulomas. Peripheral blood NK cell percentages positively correlate with the suppression of GPA activity and could serve as a biomarker for GPA activity. Peripheral blood NK cells in GPA patients are mature NK cells with preserved immune recognition