13 research outputs found

    BIOLOGICAL ACTIVITY EVALUATION OF NOVEL N-HETEROCYCLIC CARBENE PRECURSORS

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    Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a-e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds (1a-e) showed no activity against the test yeast C. albicans

    In vitro antimicrobial studies of new benzimidazolium salts and silver N-heterocyclic carbene complexes

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    A series of new benzimidazolium salts (1a-g) were synthesized from the reaction of 1-(4-vinylbenzyl) benzimidazole with various alkyl halides. These salts were used to synthesize silver N-heterocyclic carbene (Ag-NHC) complexes (2a-f). The thirteen compounds were characterized by FT-IR, NMR (H-1 and C-13) spectroscopic methods and an elemental analysis technique. These selected candidates were tested for their in vitro antimicrobial activities. Antibacterial and antifungal results indicated that the new salts, and particularly their silver complexes, were found to be strongly effective against seven Gram (-) bacterial strains, three Gram (+) bacterial strains and one yeast (Candida albicans)

    A Rare Pathogen in a Burn Patient: Pantoea agglomerans

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    Children with burn injuries are prone to increased risk for infection. Pantoea agglomerans is a particularly uncommon microorganism related to burn wound infections. A previously healthy, 28-month-old-boy was admitted with scald due to hot water. His general condition was moderate with normal vital signs. He had full thickness (right anterior forearm, 1.5%) and partial thickness (upper part of left arm, 0.5%; left anterior forearm, 2%; right thigh, 1%; right leg, 0.5%; left thigh, 0.5%; and left leg, 1%) burn wounds with totally estimated surface area percentage of 7%. Laboratory findings (hemogram, C-reactive protein, erythrocyte sedimentation rate, and blood biochemistry) were unremarkable. As well as hemodynamic stabilization and nutritional support, daily dressing with silver sulfadiazine was performed. Ten days later, grafting was carried out as the wound on right anterior forearm did not heal. Prophylactic intravenous cefazolin treatment (50mg/kg/day) was started. Four days after operation, he had 38.8°C fever and wound infection was realized. Gram stain of the swab revealed gram negative rods. Antibiotic treatment changed to ceftriaxone (75 mg/kg/day). While blood culture was negative, swab culture grew Pantoea agglomerans, resistant to cefazolin, sensitive to ceftriaxone. His fever subsided after 24 hours of ceftriaxone treatment and he was discharged on the 10th day. His immunological investigation was normal. One week later on control examination, his lesion was epithelized. Burn wound infections in pediatric age group can be caused by rare organisms. Other than presence of immunodeficiency, a graft tissue may ease this situation. [Med-Science 2016; 5(3.000): 878-83

    Al/Zn/Al2O3 and Zn/Al2O3 Coatings by Cold Spray Coating Method of WE43 Magnesium Alloy and Investigation of Its Wear Behaviors

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    Mg alloys are preferred in automotive, aircraft, aerospace and communication industries due to their low specific gravity and high strength. WE series is a series of Mg alloys containing Mg, Y, Nd, rare earth elements, and although the creep strength is good for this alloy series, the wear resistance is open to improvement. The aim of this study is to develop coatings that can increase the wear resistance of WE43 Mg alloys, which have a high potential for use due to their specific gravity, by using a method that can be easily applied in the industry. For this purpose, using the cold spray coating method, magnesium alloys, whose surfaces are highly active, are provided to be coated without oxidation and wear resistance is improved. In the study carried out, WE43 Mg alloys, which roughen the surfaces by fine sandblasting process, were used with cold spray method, using powders containing Al/Zn/Al2O3 and Zn/Al2O3 and trade names DYMET K-20-11 and DYMET K-00-11, respectively, using N2 shielding gas at 500 degrees C. 6 g/min for powders delivered to supersonic speeds under the atmosphere. The powder was sprayed onto the substrates using the feed rate. Morphological analysis of the coated and uncoated samples with different contents were examined by SEM, XRD methods, the coating thicknesses were measured with SEM images taken from the section, and the percentages of the elements were determined by EDS analysis. In addition, ball-on disc wear tests were performed to examine the wear performance and volume losses were evaluated. As a result, the wear loss of WE43 alloys was reduced by approximately 40% compared to the uncoated condition, thanks to the cold spray coatings

    Remembering the Importance of an Old Friend: History Taking in Preoperative Evaluation of Healthy Children: A Single Center Experience

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    Albayrak, Meryem/0000-0003-2711-5150WOS: 000386045600005Objective: To investigate the consequences of routine laboratory tests that lead to surgical delay or high cost in patients with a normal medical history and physical examination who undergo minor surgical interventions. Patients and Method: Files of 1,322 patients aged between 0-16 years that had undergone elective surgical intervention within six years were reviewed. Results: Of the 1,322 patients, 1,246 (94.3%) had normal physical examination and laboratory findings. Seventy-six children who had abnormalities in laboratory findings and physical examination were referred to pediatrics. Of the 76 pediatric referees, 42 (55.3%) were reevaluated and were diagnosed with upper respiratory tract infection (n=23; 30.2%), iron deficiency anemia (n=5; 6.5%), innocent murmur (n=4; 5.3%), thalassemia minor (n=2; 2.6%), lower respiratory tract infection (n=2; 2.6%), urinary tract infection (n=1; 1.3%), mumps (n=1; 1.3%), acute gastroenteritis (n=1; 1.3%), minimal aortic and tricuspid valve insufficiency (n=1; 1.3%), minimal aortic stenosis (n=1; 1.3%), atrial septal defect (n=1; 1.3%). Surgical interventions were delayed until the recovery of the infectious diseases. In 25 of the patients, repeated tests showed normal ranges after the second test; however nine (n=9) of the patients showed increased or decreased numbers of white blood cell counts and whose medical history and physical examination revealed signs and symptoms related to infection. Conclusion: Routine laboratory tests contribute little to preoperative evaluation of children with normal history and physical examination undergoing low grade surgery

    Prevalence, etiology, and biopsychosocial risk factors of cervicogenic dizziness in patients with neck pain: A multi-center, cross-sectional study

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    Objectives: This study aims to investigate the prevalence, etiology, and risk factors of cervicogenic dizziness in patients with neck pain. Patients and methods: Between June 2016 and April 2018, a total of 2,361 patients (526 males, 1,835 females; mean age: 45.0 +/- 13.3 years; range, 18 to 75 years) who presented with the complaint of neck pain lasting for at least one month were included in this prospective, cross-sectional study. Data including concomitant dizziness, severity, and quality of life (QoL) impact of vertigo (via Numeric Dizziness Scale [NDS]), QoL (via Dizziness Handicap Inventory [DHI]), mobility (via Timed Up-and-Go [TUG] test), balance performance [via Berg Balance Scale [BBS]), and emotional status (via Hospital Anxiety Depression Scale [HADS]) were recorded. Results: Dizziness was evident in 40.1% of the patients. Myofascial pain syndrome (MPS) was the most common etiology for neck pain (58.5%) and accompanied with cervicogenic dizziness in 59.7% of the patients. Female versus male sex (odds ratio [OR]: 1.641, 95% CI: 1.241 to 2.171, p=0.001), housewifery versus other occupations (OR: 1.285, 95% CI: 1.006 to 1.642, p=0.045), and lower versus higher education (OR: 1.649-2.564, p<0.001) significantly predicted the increased risk of dizziness in neck pain patients. Patient with dizziness due to MPS had lower dizziness severity scores (p=0.034) and milder impact of dizziness on QoL (p=0.005), lower DHI scores (p=0.004), shorter time to complete the TUG test (p=0.001) and higher BBS scores (p=0.001). Conclusion: Our findings suggest a significant impact of biopsychosocial factors on the likelihood and severity of dizziness and association of dizziness due to MPS with better clinical status
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