Future proofing the biosecurity of New Zealand

Biosecurity is widely viewed by industry to be critical to the economic prosperity of New Zealand. This article is an overview of the challenges this country faces in preventing and managing pest, weeds and diseases. The next 10 years will see dramatic changes in how scientists, industry and the general public contribute to the biosecurity system. These changes should lead to a more efficient and coordinated approach, but they will also increase uncertainties about the way we predict and respond to the future risks we might face

Better communication research project : language and literacy attainment of pupils during early years and through KS2 : does teacher assessment at five provide a valid measure of children's current and future educational attainments?

It is well-established that language skills are amongst the best predictors of educational success. Consistent with this, findings from a population-based longitudinal study of parents and children in the UK indicate that language development at the age of two years predicts children’s performance on entering primary school. Moreover, children who enter school with poorly developed speech and language are at risk of literacy difficulties and educational underachievement is common in such children. Whatever the origin of children’s problems with language and communication, the poor educational attainment of children with language learning difficulties is an important concern for educational polic

Adding to the midwifery curriculum through internationalisation and promotion of global mobility

Despite the obvious need for student midwives to be exposed to meaningful learning experiences that consider engagement in the wider context of international health care and the associated benefits, there is a lack of information on how this is achieved within midwifery curricula both nationally and internationally. At the University of Nottingham, work has been undertaken to ensure the midwifery curriculum is internationalised and global mobility is promoted to all midwifery students. Processes and strategies have been put in place to encourage students' mobility including the Erasmus+ programme, elective placements and short-term ad hoc international opportunities. Thanks to the strategies that have been implemented, the Division of Midwifery has seen an increase in students undertaking an international placement from 5% in 2013/14 to 18% in 2015/16. Moving forward, future works will aim to develop ‘virtual mobility’ projects and evaluate the Erasmus+ programme in conjunction with European partners

AUDITORS’ USE OF BASE RATE EVIDENCE: INSIGHTS FROM A COGNITIVE STYLES MODEL

Good auditors sometimes draw different conclusions from quite similar audit evidence. This may result from differences in auditors’ information gathering and processing styles. In particular, differences in auditors’ cognitive styles preferences may lead to differential reliance on base rate evidence. Base rate evidence -- such as information from auditors’ past judgments -- is important because it is both relevant and inexpensive. One line of research suggests under-utilization of such evidence in the opinion forming process; another suggests the opposite. A comparison of methodological differences indicates that the framing of the experimental tasks may be contributing to the conflicting results. This paper presents the results of an empirical investigation of framing effects in evidence use and provides support for the proposition that framing may be an important factor. In addition, the use of cognitive styles models is proposed as a possible basis for explaining individual differences in base rate and sample evidence use

Dietary value for money? Investigating how the monetary value of diets in the National Diet and Nutrition Survey (NDNS) relate to dietary energy density

Estimating the monetary value of individuals’ diets allows investigation into how costs relate to dietary quality. A number of studies(1–2), including one in Scotland(3), have reported a strong negative relationship between diet costs and energy density. Most studies of this type neglect to address the issue of mathematical coupling, where energy is both the numerator in the energy density variable (kJ/g) and the denominator in energy-adjusted diet cost (e.g. E/10 MJ). As a result, the findings could be reflecting a mathematical relationship(4). This study investigated how estimated diet costs of NDNS adults relate to dietary energy density using the ‘residuals’ regressionmethod to account for energy. Diet diary information from 2008–2010 was matched to an in-house database of national average (2004) food prices (the DANTE cost database) to assign a cost to each food and non-alcoholic beverage consumed. Mean daily diet costs and costs per 10 MJ were calculated for each participant. Energy density (g/kJ) was derived from foods and milk. The sample median diet cost was £2.84 per day (IQR £2.27, £3.64), or £4.05 per 10MJ (£3.45, £4.82). Values for energy density, food energy, and diet costs by quintiles of dietary energy density (1 = least energy dense) are presented in the table. Adjusted linear regression found a strong negative relationship: additional standard deviation above the diet cost expected for a given energy intake (the residual), there was an associated decrease in energy density of 0.46kJ/g (95% CI - 0.53, - 0.38, p<0.001). This is the first time individual-level diet costs have been characterized for a representative British population. These diet costs represent the inherent value of the diet, and are not comparable to UK expenditure data. The analyses confirm a diet cost-energy density link that is not due to mathematical artefact, and suggest that those consuming more energy-dense diets are achieving more kilojoules for their money

4-(Piperidin-1-yl)-4H-benzo[b]tetra­zolo[1,5-d][1,4]diazepin-5(6H)-one

There are two crystallographically unique mol­ecules present in the asymmetric unit of the title compound, C14H16N6O; in both mol­ecules, the seven-membered diazepinone ring adopts a boat-like conformation and the chair conformation piperidine ring is an axial substituent on the diazepinone ring. In the crystal, each mol­ecule forms hydrogen bonds with its respective symmetry equivalents. Hydrogen bonding between mol­ecule A and symmetry equivalents forms two ring motifs, the first formed by inversion-related N—H⋯O inter­actions and the second formed by C—H⋯O and C—H⋯N inter­actions. The combination of both ring motifs results in the formation of an infinite double tape, which propagates in the a-axis direction. Hydrogen bonding between mol­ecule B and symmetry equivalents forms one ring motif by inversion-related N—H⋯O inter­actions and a second ring motif by C—H⋯O inter­actions, which propagate as a single tape parallel with the c axis

Advancing One Biosecurity to address the pandemic risks of biological invasions

The world is witnessing a global rise in numbers of emerging invasive alien species, but identifying which species pose a pandemic threat remains poorly understood. The disjointed international regulatory environment presents a significant challenge to biosecurity interventions at a global scale. A novel way forward is through One Biosecurity, an interdisciplinary approach to biosecurity policy and research that enhances the interconnections between human, animal, plant, and environmental health to prevent and mitigate the impacts of invasive alien species. One Biosecurity underpins three initiatives essential to deal with the pandemic risks from biological invasions: new risk assessment tools that look beyond national borders toward biosecurity risks of international concern, a stronger regulatory instrument to address biosecurity threats at a worldwide scale, and the establishment of a multilateral biosecurity convention responsible for biosecurity governance. Together, these initiatives will drive a new science and policy agenda to deliver evidence-based governance of global biosecurity

New methods for the synthesis of spirocyclic cephalosporin analogues

Spiro compounds provide attractive targets in drug discovery due to their inherent three-dimensional structures, which enhance protein interactions, aid solubility and facilitate molecular modelling. However, synthetic methodology for the spiro-functionalisation of important classes of penicillin and cephalosporin β-lactam antibiotics is comparatively limited. We report a novel method for the generation of spiro-cephalosporin compounds through a Michael-type addition to the dihydrothiazine ring. Coupling of a range of catechols is achieved under mildly basic conditions (K2CO3, DMF), giving the stereoselective formation of spiro-cephalosporins (d.r. 14:1 to 8:1) in moderate to good yields (28−65%)

The next generation: design and the infrastructure for learning in a mobile and networked world

Focusing on intermediate and institutional levels of design for learning, this chapter explores how institutional decisions relate to design, using recent experience at The Open University as a case study. To illuminate the relationship between institutional decisions and learner-focused design, we review and bring together some of the research on learner practices in mobile and networked learning. We take a critical stance in relation to the concept of generation, which has been applied to understanding learners of different ages using terms such as net generation and digital natives. Following on from this, we propose an integrated pedagogical design approach that takes account of learner practices, spaces for learning, and technologies. The chapter also proposes future research directions focused on the changing context for learning, a distinction between place and space and an understanding of how the different levels of educational systems interact with mobile and networked technologies