The Quantum Geometry of N=(2,2) Non-Linear Sigma-Models

We consider a general N=(2,2) non-linear sigma-model in (2,2) superspace. Depending on the details of the complex structures involved, an off-shell description can be given in terms of chiral, twisted chiral and semi-chiral superfields. Using superspace techniques, we derive the conditions the potential has to satisfy in order to be ultra-violet finite at one loop. We pay particular attention to the effects due to the presence of semi-chiral superfields. A complete description of N=(2,2) strings follows from this.Comment: 9 pages, Late

Nonholomorphic Corrections to the One-Loop N=2 Super Yang-Mills Action

In addition to the familiar contribution from a holomorphic function \FF, the K\"ahler potential of the scalars in the nonabelian $N=2$ vector multiplet receives contributions from a real function \HH. We determine the latter at the one-loop level, taking into account both supersymmetric matter and gauge loops. The function \HH characterizes the four-point coupling of the $N=2$ vector-multiplet vectors for constant values of their scalar superpartners. We discuss the consequences of our results.Comment: 11 pages, Latex, one Postscript figure. Corrections to equation (24): 1 missing term added and one pair of indices interchange

Holonomy groups and W-symmetries

Irreducible sigma models, i.e. those for which the partition function does not factorise, are defined on Riemannian spaces with irreducible holonomy groups. These special geometries are characterised by the existence of covariantly constant forms which in turn give rise to symmetries of the supersymmetric sigma model actions. The Poisson bracket algebra of the corresponding currents is a W-algebra. Extended supersymmetries arise as special cases.Comment: pages 2

The WZNW Model at Two Loops

We study perturbatively the (conformal) WZNW model. At one loop we compute one-particle irreducible two- and three-point current correlation functions, both in the conventional version and in the classically equivalent, chiral, nonlocal, induced version of the model. At two loops we compute the two-point function and find that it vanishes (modulo infrared-induced logarithms). We use dimensional regularization and the $R^*$ operation for removing infrared divergences. The outcome of the calculations is insensitive to the treatment of the \varepsilon^{\m\n} tensor as a two-dimensional or $d$-dimensional object. Our results indicate that the one-particle irreducible current correlation functions constitute an effective action equal to the original WZNW action with the familiar level shift, $k\to k+\tilde h$.Comment: 40 pages, Latex, (4 postscript figures at end of file, to be split off into files called diag1.ps,...,diag4.ps),THU-93/1

Families of N=2 Strings

In a given 4d spacetime bakcground, one can often construct not one but a family of distinct N=2 string theories. This is due to the multiple ways N=2 superconformal algebra can be embedded in a given worldsheet theory. We formulate the principle of obtaining different physical theories by gauging different embeddings of the same symmetry algebra in the same ``pre-theory.'' We then apply it to N=2 strings and formulate the recipe for finding the associated parameter spaces of gauging. Flat and curved target spaces of both (4,0) and (2,2) signatures are considered. We broadly divide the gauging choices into two classes, denoted by alpha and beta, and show them to be related by T-duality. The distinction between them is formulated topologically and hinges on some unique properties of 4d manifolds. We determine what their parameter spaces of gauging are under certain simplicity ansatz for generic flat spaces (R^4 and its toroidal compactifications) as well as some curved spaces. We briefly discuss the spectra of D-branes for both alpha and beta families.Comment: 66+1 pages, 2 tables, latex 2e, hyperref. ver2: typos corrected, reference adde

The dS/CFT Correspondence and the Big Smash

Recent observations suggest that the cosmological equation-of-state parameter w is close to -1. To say this is to imply that w could be slightly less than -1, which leads to R.Caldwell's "Phantom cosmologies". These often have the property that they end in a "Big Smash", a final singularity in which the Universe is destroyed in a finite proper time by excessive *expansion*. We show that, classically, this fate is not inevitable: there exist Smash-free Phantom cosmologies, obtained by a suitable perturbation of the deSitter equation of state, in which the spacetime is in fact asymptotically deSitter. [Contrary to popular belief, such cosmologies, which violate the Dominant Energy Condition, do not necessarily violate causality.] We also argue, however, that the physical interpretation of these classically acceptable spacetimes is radically altered by ``holography'', as manifested in the dS/CFT correspondence. It is shown that, if the boundary CFTs have conventional properties, then recent ideas on "time as an inverse renormalization group flow" can be used to rule out these cosmologies. Very recently, however, it has been argued that the CFTs in dS/CFT are of a radically unconventional form, and this opens up the possibility that Smash-free Phantom spacetimes offer a simple model of a "bouncing" cosmology in which the quantum-mechanical entanglement of the field theories in the infinite past and future plays an essential role.Comment: 22 pages, clarification of triple analytic continuation, additional Comments added in the light of hep-th/020724

Non-commutative Branes from M-theory

The analysis of the worldvolume effective actions of the M-theory Kaluza-Klein monopole and 9-brane suggests that it should be possible to describe non-abelian configurations of M2-branes or M5-branes if the M2-branes are transverse to the eleventh direction and the M5-branes are wrapped on it. This is determined by the fact that the Kaluza-Klein monopole and the M9-brane are constrained to move in particular isometric spacetimes. We show that the same kind of situation is implied by the analysis of the brane descent relations in M-theory. We compute some of the non-commutative couplings of the worldvolume effective actions of these non-abelian systems of M2 and M5 branes and show that they indicate the existence of configurations corresponding to N branes expanding into a higher dimensional M-brane. The reduction to Type II brings up new descriptions of coincident D-branes at strong coupling. We show that these systems have the right non-commutative charges to describe certain expanded configurations playing a role in the framework of the AdS/CFT correspondence. Finally, we discuss the realization of non-commutative brane configurations as topological solitons in non-abelian brane-antibrane systems.Comment: 31 pages, latex file, references adde

Mouse Chromosome 11

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46996/1/335_2004_Article_BF00648429.pd

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease