Macrophages induce gingival destruction via Piezo1-mediated MMPs-degrading collagens in periodontitis

Macrophages are an integral part of the innate immune response in periodontal tissue and play a crucial role in the progression of periodontitis. Here we reported that macrophages also provoke periodontitis-induced gingival destruction through Piezol-mediated collagen degradation. We discovered that the PIEZO1 expression was markedly elevated in patients with periodontitis through transcriptomic profiling. Moreover, Piezo1 promoted macrophage polarization toward the M1 type in response to lipopolysaccharide (LPS) and induced production of proinflammatory cytokines, which in turn stimulated production of matrix metalloproteinases (MMPs) leading to collagen degradation. Our study suggests that Piezol might be a potential therapeutic target for treating periodontitis-induced gingival destruction

XJ_COTTON10: The 10-m cotton maps in Xinjiang, China during 2018-2021

<p>The datasets accompany the paper "The 10-m cotton maps in Xinjiang, China during 2018–2021" that was published in <a href="https://doi.org/10.1038/s41597-023-02584-3"><i>Scientific Data</i></a> on Oct. 10, 2023. The datasets contain the 10-m cotton maps of Xinjiang (XJ_COTTON10) from 2018 to 2021. They were developed through supervised classification using high-quality in-field samples and multi-source remote sensing data on the Google Earth Engine (GEE) platform.</p><p><strong>Citation</strong>:</p><p>[1] Kang, X., Huang, C., Chen, J.M., Lv, X., Wang, J., Zhong, T., Wang, H., Fan, X., Ma, Y., Yi, X., Zhang, Z., Zhang, L., Tong, Q., 2023. The 10-m cotton maps in Xinjiang, China during 2018-2021. Sci Data 10, 688. doi:10.1038/s41597-023-02584-3</p><p>[2] Lang, P., Zhang, L., Huang, C., Chen, J., Kang, X., Zhang, Z., Tong, Q., 2023. Integrating environmental and satellite data to estimate county-level cotton yield in Xinjiang Province. Frontiers in Plant Science 13, 1048479. doi:10.3389/fpls.2022.1048479</p><p>[3] Kang, X., Huang, C., Zhang, L., Zhang, Z., Lv, X., 2022. Downscaling solar-induced chlorophyll fluorescence for field-scale cotton yield estimation by a two-step convolutional neural network. Computers and Electronics in Agriculture 201, 107260. doi:10.1016/j.compag.2022.107260</p><p>[4] Kang, X., Huang, C., Zhang, L., Wang, H., Zhang, Z., Lv, X., 2023. Regional-scale cotton yield forecast via data-driven spatio-temporal prediction (STP) of solar-induced chlorophyll fluorescence (SIF). Remote Sensing of Environment 299, 113861. doi:10.1016/j.rse.2023.113861</p&gt

Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study

Introduction Gallbladder cancer (GBC), the sixth most common gastrointestinal tract cancer, poses a significant disease burden in China. However, no national representative data are available on the clinical characteristics, treatment and prognosis of GBC in the Chinese population.Methods and analysis The Chinese Research Group of Gallbladder Cancer (CRGGC) study is a multicentre retrospective registry cohort study. Clinically diagnosed patient with GBC will be identified from 1 January 2008 to December, 2019, by reviewing the electronic medical records from 76 tertiary and secondary hospitals across 28 provinces in China. Patients with pathological and radiological diagnoses of malignancy, including cancer in situ, from the gallbladder and cystic duct are eligible, according to the National Comprehensive Cancer Network 2019 guidelines. Patients will be excluded if GBC is the secondary diagnosis in the discharge summary. The demographic characteristics, medical history, physical examination results, surgery information, pathological data, laboratory examination results and radiology reports will be collected in a standardised case report form. By May 2021, approximately 6000 patient with GBC will be included. The clinical follow-up data will be updated until 5 years after the last admission for GBC of each patient. The study aimed (1) to depict the clinical characteristics, including demographics, pathology, treatment and prognosis of patient with GBC in China; (2) to evaluate the adherence to clinical guidelines of GBC and (3) to improve clinical practice for diagnosing and treating GBC and provide references for policy-makers.Ethics and dissemination The protocol of the CRGGC has been approved by the Committee for Ethics of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (SHEC-C-2019–085). All results of this study will be published in peer-reviewed journals and presented at relevant conferences.Trial registration number NCT04140552, Pre-results