1,684 research outputs found
The effects of plant-based diets on the body and the brain: A systematic review
Western societies notice an increasing interest in plant-based eating patterns such as vegetarian and vegan, yet potential effects on the body and brain are a matter of debate. Therefore, we systematically reviewed existing human interventional studies on putative effects of a plant-based diet on the metabolism and cognition, and what is known about the underlying mechanisms. Using the search terms “plant-based OR vegan OR vegetarian AND diet AND intervention” in PubMed filtered for clinical trials in humans retrieved 205 studies out of which 27, plus an additional search extending the selection to another five studies, were eligible for inclusion based on three independent ratings. We found robust evidence for short- to moderate-term beneficial effects of plant-based diets versus conventional diets (duration ≤ 24 months) on weight status, energy metabolism and systemic inflammation in healthy participants, obese and type-2 diabetes patients. Initial experimental studies proposed novel microbiome-related pathways, by which plant-based diets modulate the gut microbiome towards a favorable diversity of bacteria species, yet a functional “bottom up” signaling of plant-based diet-induced microbial changes remains highly speculative. In addition, little is known, based on interventional studies about cognitive effects linked to plant-based diets. Thus, a causal impact of plant-based diets on cognitive functions, mental and neurological health and respective underlying mechanisms has yet to be demonstrated. In sum, the increasing interest for plant-based diets raises the opportunity for developing novel preventive and therapeutic strategies against obesity, eating disorders and related comorbidities. Still, putative effects of plant-based diets on brain health and cognitive functions as well as the underlying mechanisms remain largely unexplored and new studies need to address these questions
Scaling of the specific heat in superfluid films
We study the specific heat of the model on lattices with (i.e. on lattices representing a film geometry) using the
Cluster Monte--Carlo method. In the --direction we apply Dirichlet boundary
conditions so that the order parameter in the top and bottom layers is zero. We
find that our results for the specific heat of various thickness size
collapse on the same universal scaling function. The extracted scaling function
of the specific heat is in good agreement with the experimentally determined
universal scaling function using no free parameters.Comment: 4 pages, uuencoded compressed PostScrip
Quality predictors of abdominal fetal electrocardiography recording in antenatal ambulatory and bedside settings
Background: Fetal electrocardiography using an abdominal monitor (Monica AN24™) could increase the diagnostic use of fetal heart rate (fHR) variability measurements. However, signal quality may depend on factors such as maternal physical activity, posture, and bedside versus ambulatory setting. Methods: Sixty-three healthy women wore the monitor at home and 42 women during a hospital stay. All women underwent a posture experiment, and all home and 13 hospital participants wore the monitor during daytime and nighttime. The success rate (SR) of fHR detection was analyzed in relation to maternal physical activity, posture, daytime versus nighttime, and other maternal and fetal predictors. Results: Ambulatorily, the SR was 86.8% for nighttime and 40.2% for daytime. The low daytime SR was largely due to effects of maternal physical activity and posture. The in-hospital SR was lower during nighttime (71.1%) and similar during daytime (43.3%). SR was related to gestational age, but not affected by pre-pregnancy and current body mass index or fetal growth restriction. Conclusions: The success of beat-to-beat fHR detection strongly depends on the home/hospital setting and predictors such as time of recording, activity levels, and maternal posture. Its clinical utility may be limited in periods of unsupervised recording with physical activity or posture shifts
The three-nucleon bound state using realistic potential models
The bound states of H and He have been calculated using the Argonne
plus the Urbana three-nucleon potential. The isospin state
have been included in the calculations as well as the - mass difference.
The H-He mass difference has been evaluated through the charge
dependent terms explicitly included in the two-body potential. The calculations
have been performed using two different methods: the solution of the Faddeev
equations in momentum space and the expansion on the correlated hyperspherical
harmonic basis. The results are in agreement within 0.1% and can be used as
benchmark tests. Results for the CD-Bonn interaction are also presented. It is
shown that the H and He binding energy difference can be predicted
model independently.Comment: 5 pages REVTeX 4, 1 figures, 6 table
The Specific Heat of a Ferromagnetic Film.
We analyze the specific heat for the vector model on a -dimensional
film geometry of thickness using ``environmentally friendly''
renormalization. We consider periodic, Dirichlet and antiperiodic boundary
conditions, deriving expressions for the specific heat and an effective
specific heat exponent, \alpha\ef. In the case of , for , by
matching to the exact exponent of the two dimensional Ising model we capture
the crossover for \xi_L\ra\infty between power law behaviour in the limit
{L\over\xi_L}\ra\infty and logarithmic behaviour in the limit
{L\over\xi_L}\ra0 for fixed , where is the correlation length in
the transverse dimensions.Comment: 21 pages of Plain TeX. Postscript figures available upon request from
[email protected]
A Human Recombinant Autoantibody-Based Immunotoxin Specific for the Fetal Acetylcholine Receptor Inhibits Rhabdomyosarcoma Growth In Vitro and in a Murine Transplantation Model
Rhabdomyosarcoma (RMS) is the most common malignant soft tissue tumor in children and
is highly resistant to all forms of treatment currently available once metastasis or relapse has commenced. As it has recently been determined that the acetylcholine receptor (AChR) γ-subunit, which defines the fetal AChR (fAChR) isoform, is almost exclusively expressed in RMS post partum, we recombinantly fused a single chain variable fragment (scFv) derived from a fully human anti-fAChR Fab-fragment to Pseudomonas exotoxin A to generate an anti-fAChR immunotoxin (scFv35-ETA). While scFv35-ETA had no damaging effect on fAChR-negative control cell lines, it killed human embryonic and alveolar RMS cell lines in vitro and delayed RMS development in a murine transplantation model. These results indicate that scFv35-ETA may be a valuable new therapeutic tool as well as a relevant step towards the development of a fully human immunotoxin directed against RMS. Moreover, as approximately 20% of metastatic malignant melanomas (MMs) display rhabdoid features
including the expression of fAChR, the immunotoxin we developed may also prove to be of significant use in the treatment of these more common and most often fatal neoplasms
Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice
Peer reviewedPublisher PD
The role of ongoing dendritic oscillations in single-neuron dynamics
The dendritic tree contributes significantly to the elementary computations a neuron performs while converting its synaptic inputs into action potential output. Traditionally, these computations have been characterized as temporally local, near-instantaneous mappings from the current input of the cell to its current output, brought about by somatic summation of dendritic contributions that are generated in spatially localized functional compartments. However, recent evidence about the presence of oscillations in dendrites suggests a qualitatively different mode of operation: the instantaneous phase of such oscillations can depend on a long history of inputs, and under appropriate conditions, even dendritic oscillators that are remote may interact through synchronization. Here, we develop a mathematical framework to analyze the interactions of local dendritic oscillations, and the way these interactions influence single cell computations. Combining weakly coupled oscillator methods with cable theoretic arguments, we derive phase-locking states for multiple oscillating dendritic compartments. We characterize how the phase-locking properties depend on key parameters of the oscillating dendrite: the electrotonic properties of the (active) dendritic segment, and the intrinsic properties of the dendritic oscillators. As a direct consequence, we show how input to the dendrites can modulate phase-locking behavior and hence global dendritic coherence. In turn, dendritic coherence is able to gate the integration and propagation of synaptic signals to the soma, ultimately leading to an effective control of somatic spike generation. Our results suggest that dendritic oscillations enable the dendritic tree to operate on more global temporal and spatial scales than previously thought
Perturbative calculation of the scaled factorial moments in second-order quark-hadron phase transition within the Ginzburg-Landau description
The scaled factorial moments are studied for a second-order
quark-hadron phase transition within the Ginzburg-Landau description. The role
played by the ground state of the system under low temperature is emphasized.
After a local shift of the order parameter the fluctuations are around the
ground state, and a perturbative calculation for can be carried out.
Power scaling between 's is shown, and a universal scaling exponent
is given for the case with weak correlations and weak
self-interactions.Comment: 12 pages in RevTeX, 12 eps figure
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