A Chakraborty

AE Chernoff

B Namangala

Barbara Bradley

CA Hunter

DN Amin

E Di Santo

FW Jennings

J Rodgers

Jayne Raper

Jean Rodgers

Jeremy M. Sternberg

JM Sternberg

K Asadullah

L MacLean

M Guilliams

P Kobbe

Peter G. E. Kennedy

PG Kennedy

RD Huhn

U Frevert

W Masocha

English

PubMed

Rodgers, Jean

BRADLEY, Barbara

Kennedy, Peter G.E.

Sternberg, Jeremy M

Aberdeen University Research

Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice

Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the Trypanosoma brucei brucei GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ and TNF-α concentrations, CNS parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. The results provide evidence that CNS invasion may be susceptible to immunological attenuation

Peter G E Kennedy

Jeremy M Sternberg

Directory of Open Access Journals

PLoS Neglected Tropical Diseases

Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice.

Bradley, Barbara

Sternberg, Jeremy M.

Enlighten: Publications

Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice

Funding: The study was funded by the Wellcome Trust grants 082786 and 094691 (www.wellcome.ac.uk). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewe

Kennedy, Peter GE

Crossref

Enlighten

<div><p>Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the <i>Trypanosoma brucei brucei</i> GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ and TNF-α concentrations, CNS parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. The results provide evidence that CNS invasion may be susceptible to immunological attenuation.</p></div

Jean Rodgers (206658)

Barbara Bradley (206676)

Peter G. E. Kennedy (126080)

Jeremy M. Sternberg (126082)

The Francis Crick Institute

Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in <i>Trypanosoma brucei</i>-Infected Mice

Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice

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Aberdeen University Research

Directory of Open Access Journals

Enlighten: Publications

Aberdeen University Research

Crossref

Crossref

Enlighten

The Francis Crick Institute