2,174 research outputs found
Radiative lifetime measurements of rubidium Rydberg states
We have measured the radiative lifetimes of ns, np and nd Rydberg states of
rubidium in the range 28 < n < 45. To enable long-lived states to be measured,
our experiment uses slow-moving Rb atoms in a magneto-optical trap (MOT). Two
experimental techniques have been adopted to reduce random and systematic
errors. First, a narrow-bandwidth pulsed laser is used to excite the target
Rydberg state, resulting in minimal shot-to-shot variation in the initial state
population. Second, we monitor the target state population as a function of
time delay from the laser pulse using a short-duration, millimetre-wave pulse
that is resonant with a one- or two-photon transition. We then selectively
field ionize the monitor state, and detect the resulting electrons with a
micro-channel plate. This signal is an accurate mirror of the target state
population, and is uncontaminated by contributions from other states which are
populated by black body radiation. Our results are generally consistent with
other recent experimental results obtained using a less sensitive method, and
are also in excellent agreement with theory.Comment: 27 pages,6 figure
Characterization of transport of neutral and ionized species in reactive HiPIMS process
International audienceThe aim of the studyis to developa software to control in real time the thin film deposition of a plasma magnetron process. The thin films will be obtained by HiPIMS plasma process (High Power Impulse Magnetron Sputtering)[1]. Nowadays, it is the only physical process able to ensure optimal compliance ofthe coatings on complex 3D substrates. It is also easy to implement on industrial production lines thatare already equipped by conventional magnetron sputtering systems. In order to well understand this HiPIMS process and to control it by software, we will use three plasma diagnostics:absorption spectroscopy, mass spectrometry and optical emission spectroscopy(OES). The combination of the diagnostics will allow studying the behaviourof ions and neutrals created in the plasma and their transport in the spatial post-discharge. These measurements will serve to establish abacuses for the control software. We will also associate OES data with the conformity and properties of the coatings to verify if the latter could be linked with some OES lines, whose evolutions could be the signature of the imposed modifications
Analytic Kramer kernels, Lagrange-type interpolation series and de Branges spaces
The classical Kramer sampling theorem provides a method for obtaining orthogonal sampling formulas. In particular, when the involved kernel is analytic in the sampling parameter it can be stated in an abstract setting of reproducing kernel Hilbert spaces of entire functions which includes as a particular case the classical Shannon sampling theory. This abstract setting allows us to obtain a sort of converse result and to characterize when the sampling formula associated with an analytic Kramer kernel can be expressed as a Lagrange-type interpolation series. On the other hand, the de Branges spaces of entire functions satisfy orthogonal sampling formulas which can be written as Lagrange-type interpolation series. In this work some links between all these ideas are established
Full-length and C-terminal neurogranin in Alzheimer's disease cerebrospinal fluid analyzed by novel ultrasensitive immunoassays
Background: Neurogranin (Ng) is a neuron-specific and postsynaptic protein that is abundantly expressed in the
brain, particularly in the dendritic spine of the hippocampus and cerebral cortex. The enzymatic cleavage of Ng
produces fragments that are released into cerebrospinal (CSF), which have been shown to be elevated in
Alzheimer’s disease (AD) patients and predict cognitive decline. Thus, quantification of distinctive cleavage products
of Ng could elucidate different features of the disease.
Methods: In this study, we developed novel ultrasensitive single molecule array (Simoa) assays for measurement of
full-length neurogranin (FL-Ng) and C-terminal neurogranin (CT-Ng) fragments in CSF. The Ng Simoa assays were
evaluated in CSF samples from AD patients (N = 23), mild cognitive impairment due to AD (MCI-AD) (N = 18), and
from neurological controls (N = 26).
Results: The intra-assay repeatability and inter-assay precision of the novel methods had coefficients of variation
below 7% and 14%, respectively. CSF FL-Ng and CSF CT-Ng median concentrations were increased in AD patients
(6.02 ng/L, P < 0.00001 and 452 ng/L, P = 0.00001, respectively) and in patients with MCI-AD (5.69 ng/L, P < 0.00001
and 566 ng/L, P < 0.00001) compared to neurological controls (0.644 ng/L and 145 ng/L). The median CSF ratio of
CT-Ng/FL-Ng were decreased in AD patients (ratio = 101, P = 0.008) and in patients with MCI-AD (ratio = 115, P =
0.016) compared to neurological controls (ratio = 180). CSF of FL-Ng, CT-Ng, and ratio of CT-Ng/FL-Ng could each
significantly differentiate AD patients from controls (FL-Ng, AUC = 0.907; CT-Ng, AUC = 0.913; CT-Ng/FL-Ng, AUC =
0.775) and patients with MCI-AD from controls (FL-Ng, AUC = 0.937; CT-Ng, AUC = 0.963; CT-Ng/FL-Ng, AUC = 0.785).
Conclusions: Assessments of the FL-Ng and CT-Ng levels in CSF with the novel sensitive immunoassays provide a
high separation of AD from controls, even in early phase of the disease. The novel Ng assays are robust and highly
sensitive and may be valuable tools to study synaptic alteration in AD, as well as to monitor the effect on synaptic
integrity of novel drug candidates in clinical trials
Dissection of synaptic pathways through the CSF biomarkers for predicting Alzheimer's disease
OBJECTIVE: To assess the ability of a combination of synaptic CSF biomarkers to separate AD and non-AD disorders and to help in the differential diagnosis between neurocognitive diseases. METHODS: Retrospective cross-sectional monocentric study. All participants explored with CSF assessments for neurocognitive decline were invited to participate. After complete clinical and imaging evaluations, 243 patients were included. CSF synaptic (GAP-43, neurogranin, SNAP-25 total, SNAP-25 aa40, synaptotagmin-1) and AD biomarkers were blindly quantified using ELISA or mass spectrometry. Statistical analysis compared CSF levels between various groups AD dementias n=81, MCI-AD n=30, other MCI n=49, other dementias (OD) n=49, neurological controls n=35) as well as their discriminatory powers. RESULTS: All synaptic biomarkers were significantly increased in MCI-AD and AD -dementias patients compared to other groups. All synaptic biomarkers could efficiently discriminate AD dementias from OD (AUC ≥0.80). All but synaptotagmin were also able to discriminate MCI-AD from controls (AUC ≥0.85) and AD dementias from controls (AUC ≥0.80). Overall, CSF SNAP 25aa40 had the highest discriminative power (AUC=0.93) between AD dementias and controls or OD, and AUC=0.90 between MCI-AD and controls. Higher levels were associated with two alleles of apolipoprotein E (APOE) ε4. CONCLUSION: All synaptic biomarkers tested had a good discriminatory power to distinguish patients with AD abnormal CSF from non-AD disorders. SNAP25aa40 demonstrated the highest power to discriminate AD CSF positive patients from non-AD patients and neurological controls in this cohort. CLASSIFICATION OF EVIDENCE: This retrospective study provides Class II evidence that CSF synaptic biomarkers discriminate patients with AD from non-AD patients
High density plasma deposition of device quality silicon nitride. II. Effects of thickness on the electrical properties
Dielectric behavior of SiNx films, fabricated by microwave electron cyclotron resonance discharge, has been studied as a function of film thickness on the basis of the current–voltage and the capacitance–voltage characteristics. In the thickness range (20 nm,d,80 nm), the resistivity and the critical field for SiNx were found not to be sensitive to the film thickness ~d! and which was opposite to strong dependence of the dynamic dielectric constant e d on thickness. To explain the e d behavior as a function of d, a model based on trapped space charge effects is proposed. The dominant mode of electronic conduction, determined from J –E1/2 curves and Arrhenius plots of leakage current, appears to be Poole–Frenkel emission only for thicker films (d.20 nm). Finally, the spatial profile of fixed charges reveals that SiNx /Si interface has a much greater concentration of defects than the bulk film
Ferromagnetic semiconductors
The current status and prospects of research on ferromagnetism in
semiconductors are reviewed. The question of the origin of ferromagnetism in
europium chalcogenides, chromium spinels and, particularly, in diluted magnetic
semiconductors is addressed. The nature of electronic states derived from 3d of
magnetic impurities is discussed in some details. Results of a quantitative
comparison between experimental and theoretical results, notably for Mn-based
III-V and II-VI compounds, are presented. This comparison demonstrates that the
current theory of the exchange interactions mediated by holes in the valence
band describes correctly the values of Curie temperatures T_C magnetic
anisotropy, domain structure, and magnetic circular dichroism. On this basis,
chemical trends are examined and show to lead to the prediction of
semiconductor systems with T_C that may exceed room temperature, an expectation
that are being confirmed by recent findings. Results for materials containing
magnetic ions other than Mn are also presented emphasizing that the double
exchange involving hoping through d states may operate in those systems.Comment: 18 pages, 8 figures; special issue of Semicon. Sci. Technol. on
semiconductor spintronic
Measurement of the atmospheric muon depth intensity relation with the NEMO Phase-2 tower
The results of the analysis of the data collected with the NEMO Phase-2
tower, deployed at 3500 m depth about 80 km off-shore Capo Passero (Italy), are
presented. Cherenkov photons detected with the photomultipliers tubes were used
to reconstruct the tracks of atmospheric muons. Their zenith-angle distribution
was measured and the results compared with Monte Carlo simulations. An
evaluation of the systematic effects due to uncertainties on environmental and
detector parameters is also included. The associated depth intensity relation
was evaluated and compared with previous measurements and theoretical
predictions. With the present analysis, the muon depth intensity relation has
been measured up to 13 km of water equivalent.Comment: submitted to Astroparticle Physic
All-sky Search for High-Energy Neutrinos from Gravitational Wave Event GW170104 with the ANTARES Neutrino Telescope
Advanced LIGO detected a significant gravitational wave signal (GW170104)
originating from the coalescence of two black holes during the second
observation run on January 4, 2017. An all-sky high-energy
neutrino follow-up search has been made using data from the ANTARES neutrino
telescope, including both upgoing and downgoing events in two separate
analyses. No neutrino candidates were found within s around the GW
event time nor any time clustering of events over an extended time window of
months. The non-detection is used to constrain isotropic-equivalent
high-energy neutrino emission from GW170104 to less than
erg for a spectrum
- …