Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene

Branch points and flexures in the high pressure arterial system have long been recognized as sites of unusually high turbulence and consequent stress in humans are foci for atherosclerotic lesions. We show that mice that are homozygous for a null mutation in the gene encoding an endogenous antiinflammatory cytokine, interleukin 1 receptor antagonist (IL-1ra), develop lethal arterial inflammation involving branch points and flexures of the aorta and its primary and secondary branches. We observe massive transmural infiltration of neutrophils, macrophages, and CD4(+) T cells. Animals appear to die from vessel wall collapse, stenosis, and organ infarction or from hemorrhage from ruptured aneurysms. Heterozygotes do not die from arteritis within a year of birth but do develop small lesions, which suggests that a reduced level of IL-1ra is insufficient to fully control inflammation in arteries. Our results demonstrate a surprisingly specific role for IL-1ra in the control of spontaneous inflammation in constitutively stressed artery walls, suggesting that expression of IL-1 is likely to have a significant role in signaling artery wall damage

Estimating worst case failure dependency with partial knowledge of the difficulty function

For systems using software diversity, well-established theories show that the expected probability of failure on demand (pfd) for two diverse program versions failing together will generally differ from what it would be if they failed independently. This is explained in terms of a “difficulty function” that varies between demands on the system. This theory gives insight, but no specific prediction unless we have some means to quantify the difficulty function. This paper presents a theory leading to a worst case measure of “average failure dependency” between diverse software, given only partial knowledge of the difficulty function. It also discusses the possibility of estimating the model parameters, with one approach based on an empirical analysis of previous systems implemented as logic networks, to support pre-development estimates of expected gain from diversity. The approach is illustrated using a realistic safety system example

Symmetry in the insulator - quantum Hall - insulator transitions observed in a Ge/SiGe quantum well

We examine the magnetic field driven insulator-quantum Hall-insulator transitions of the two dimensional hole gas in a Ge/SiGe quantum well. We observe direct transitions between low and high magnetic field insulators and the $\nu=1$ quantum Hall state. With increasing magnetic field, the transitions from insulating to quantum Hall and quantum Hall to insulating are very similar with respect to their transport properties. We address the temperature dependence around the transitions and show that the characteristic energy scale for the high field transition is larger.Comment: 4 page

An adaptive inelastic magnetic mirror for Bose-Einstein condensates

We report the reflection and focussing of a Bose-Einstein condensate by a new pulsed magnetic mirror. The mirror is adaptive, inelastic, and of extremely high optical quality. The deviations from specularity are less than 0.5 mrad rms, making this the best atomic mirror demonstrated to date. We have also used the mirror to realize the analog of a beam-expander, producing an ultra-cold collimated fountain of matter wavesComment: 4 pages, 4 figure

Bottom-Up and Top-Down Processes in Emotion Generation: Common and Distinct Neural Mechanisms

Emotions are generally thought to arise through the interaction of bottom-up and top-down processes. However, prior work has not delineated their relative contributions. In a sample of 20 females, we used functional magnetic resonance imaging to compare the neural correlates of negative emotions generated by the bottom-up perception of aversive images and by the top-down interpretation of neutral images as aversive. We found that (a) both types of responses activated the amygdala, although bottom-up responses did so more strongly; (b) bottom-up responses activated systems for attending to and encoding perceptual and affective stimulus properties, whereas top-down responses activated prefrontal regions that represent high-level cognitive interpretations; and (c) self-reported affect correlated with activity in the amygdala during bottom-up responding and with activity in the medial prefrontal cortex during top-down responding. These findings provide a neural foundation for emotion theories that posit multiple kinds of appraisal processes and help to clarify mechanisms underlying clinically relevant forms of emotion dysregulation.National Institutes of Health (U.S.) (Grant MH58147)National Institutes of Health (U.S.) (Grant MH076137

Anomalous diffusion with absorption: Exact time-dependent solutions

Recently, analytical solutions of a nonlinear Fokker-Planck equation describing anomalous diffusion with an external linear force were found using a non extensive thermostatistical Ansatz. We have extended these solutions to the case when an homogeneous absorption process is also present. Some peculiar aspects of the interrelation between the deterministic force, the nonlinear diffusion and the absorption process are discussed.Comment: RevTex, 16 pgs, 4 figures. Accepted in Physical Review

Quantifying the levitation picture of extended states in lattice models

The behavior of extended states is quantitatively analyzed for two dimensional lattice models. A levitation picture is established for both white-noise and correlated disorder potentials. In a continuum limit window of the lattice models we find simple quantitative expressions for the extended states levitation, suggesting an underlying universal behavior. On the other hand, these results point out that the Quantum Hall phase diagrams may be disorder dependent.Comment: 5 pages, submitted to PR

Levitation of quantum Hall critical states in a lattice model with spatially correlated disorder

The fate of the current carrying states of a quantum Hall system is considered in the situation when the disorder strength is increased and the transition from the quantum Hall liquid to the Hall insulator takes place. We investigate a two-dimensional lattice model with spatially correlated disorder potentials and calculate the density of states and the localization length either by using a recursive Green function method or by direct diagonalization in connection with the procedure of level statistics. From the knowledge of the energy and disorder dependence of the localization length and the density of states (DOS) of the corresponding Landau bands, the movement of the current carrying states in the disorder--energy and disorder--filling-factor plane can be traced by tuning the disorder strength. We show results for all sub-bands, particularly the traces of the Chern and anti-Chern states as well as the peak positions of the DOS. For small disorder strength $W$ we recover the well known weak levitation of the critical states, but we also reveal, for larger $W$, the strong levitation of these states across the Landau gaps without merging. We find the behavior to be similar for exponentially, Gaussian, and Lorentzian correlated disorder potentials. Our study resolves the discrepancies of previously published work in demonstrating the conflicting results to be only special cases of a general lattice model with spatially correlated disorder potentials. To test whether the mixing between consecutive Landau bands is the origin of the observed floating, we truncate the Hilbert space of our model Hamiltonian and calculate the behavior of the current carrying states under these restricted conditions.Comment: 10 pages, incl. 13 figures, accepted for publication in PR