2,500 research outputs found
A parametric shell analysis of the shuttle 51-L SRB AFT field joint
Following the Shuttle 51-L accident, an investigation was conducted to determine the cause of the failure. Investigators at the Langley Research Center focused attention on the structural behavior of the field joints with O-ring seals in the steel solid rocket booster (SRB) cases. The shell-of-revolution computer program BOSOR4 was used to model the aft field joint of the solid rocket booster case. The shell model consisted of the SRB wall and joint geometry present during the Shuttle 51-L flight. A parametric study of the joint was performed on the geometry, including joint clearances, contact between the joint components, and on the loads, induced and applied. In addition combinations of geometry and loads were evaluated. The analytical results from the parametric study showed that contact between the joint components was a primary contributor to allowing hot gases to blow by the O-rings. Based upon understanding the original joint behavior, various proposed joint modifications are shown and analyzed in order to provide additional insight and information. Finally, experimental results from a hydro-static pressurization of a test rocket booster case to study joint motion are presented and verified analytically
Preparing Our Kids for Education, Work and Life: A Report of the Task Force on Youth Aging Out
Summarizes a study of Massachusetts youth transitioning out of foster care, and offers recommendations for policies, practices, and resource conditions, including "Five Core Resources" to prepare them for higher education, work, and adulthood
Rapid evolution of the env gene leader sequence in cats naturally infected with feline immunodeficiency virus (FIV)
Analysing the evolution of FIV on the intra-host level is important, in order to address whether the diversity and composition of viral quasispecies affects disease progression.<p></p>
We examined the intra-host diversity and the evolutionary rates of the entire env and structural fragments of the env sequences obtained from sequential blood samples in 43 naturally infected domestic cats that displayed different clinical outcomes. We observed in the majority of cats that FIV env showed very low levels of intra-host diversity. We estimated that env evolved at the rate of 1.16 x 10-3 substitutions per site per year and demonstrated that recombinant sequences evolved faster than non-recombinant sequences. It was evident that the V3-V5 fragment of FIV env displayed higher evolutionary rates in healthy cats than in those with terminal illness. Our study provided the first evidence that the leader sequence of env, rather than the V3-V5 sequence, had the highest intra-host diversity and the highest evolutionary rate of all env fragments, consistent with this region being under a strong selective pressure for genetic variation.<p></p>
Overall, FIV env displayed relatively low intra-host diversity and evolved slowly in naturally infected cats. The maximal evolutionary rate was observed in the leader sequence of env. Although genetic stability is not necessarily a prerequisite for clinical stability, the higher genetic stability of FIV compared to HIV might explain why many naturally infected cats do not progress to AIDS rapidly.<p></p>
Warrant Enforcement in Louisville Metro and the City of St. Louis from 2006 2019: A Cross-site Analysis
This report describes and compares bench and fugitive warrant arrests in Jefferson County, Kentucky (hereinafter Louisville Metro) and the City of St. Louis, Missouri during the period 2006 to 2019. The report is based on two site-specific reports that focus on the individual jurisdictions (see "Warrant Arrests in the City of St. Louis: 2002 –2019" and "Examining Warrant Arrests in Jefferson County, Kentucky: 2006 to 2019" for additional details). The goal is to shed light on the enforcement of warrants, which are a large part of policing practice. This comparative approach provides insight into variability in the levels and nature of warrant arrests in communities with differing legal contexts and government structures. This report is a starting point to understand trends in warrant enforcement across two jurisdictions with similar social and economic landscapes. It is our hope that the findings are useful for stakeholders as they consider ways to make the criminal legal system more efficient and equitable.
Psychophysiological responses to psychological stress exposure and neural correlates in adults with mental disorders: a scoping review
Introduction: The dysregulation of psychophysiological responses to mental stressors is a common issue addressed in individuals with psychiatric conditions, while brain circuit abnormalities are often associated with psychiatric conditions and their manifestations. However, to our knowledge, there is no systematic overview that would comprehensively synthesize the literature on psychophysiological responses during laboratory-induced psychosocial stressor and neural correlates in people with mental disorders. Thus, we aimed to systematically review the existing research on psychophysiological response during laboratory-induced stress and its relationship with neural correlates as measured by magnetic resonance imaging techniques in mental disorders. Methods: The systematic search was performed on PubMed/Medline, EBSCOhost/PsycArticles, Web of Science, and The Cochrane Library databases during November 2021 following the PRISMA guidelines. Risk of bias was evaluated by employing the checklists for cross-sectional and case-control studies from Joanna Briggs Institute (JBI) Reviewers Manual. Results: Out of 353 de-duplicated publications identified, six studies were included in this review. These studies were identified as representing two research themes: (1) brain anatomy and psychophysiological response to mental stress in individuals with mental disorders, and (2) brain activity and psychophysiological response to mental stress in individuals with mental disorders. Conclusions: Overall, the evidence from studies exploring the interplay between stress psychophysiology and neural correlates in mental disorders is limited and heterogeneous. Further studies are warranted to better understand the mechanisms of how psychophysiological stress markers interplay with neural correlates in manifestation and progression of psychiatric illnesses
Exposure to weak opioids and risk of gastrointestinal tract cancers:A series of nested case-control studies
Aims: There is evidence gastrointestinal (GI) motility may play a role in the development of GI cancers. Weak opioids (codeine and dihydrocodeine) decrease GI motility, but their effect on GI cancer risk has not been assessed. We aim to assess the association between weak opioids and cancers of the GI tract. Methods: A series of nested case-control studies was conducted using Scottish general practice records from the Primary Care Clinical Informatics Unit Research database. Oesophageal (n = 2432), gastric (n = 1443) and colorectal cancer (n = 8750) cases, diagnosed between 1999 and 2011, were identified and matched with up to five controls. Weak opioid use was identified from prescribing records. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression, adjusting for relevant comorbidities and medication use. Results: There was no association between weak opioids and colorectal cancer (adjusted OR = 0.96, CI 0.90, 1.02, P = 0.15). There was an increased risk of oesophageal (adjusted OR = 1.16, CI 1.04, 1.29, P = 0.01) and gastric cancer (adjusted OR = 1.26, CI 1.10, 1.45, P = 0.001). The associations for oesophageal cancer, but not gastric cancer, were attenuated when weak opioid users were compared with users of another analgesic (adjusted OR = 1.03 CI 0.86, 1.22, P = 0.76 and adjusted OR = 1.29 CI 1.02, 1.64, P = 0.04 respectively). Conclusions: In this large population-based study, there was no consistent evidence of an association between weak opioids and oesophageal or colorectal cancer risk, but a small increased risk of gastric cancer. Further investigation is required to determine whether this association is causal or reflects residual confounding or confounding by indication.</p
Confirming the Primarily Smooth Structure of the Vega Debris Disk at Millimeter Wavelengths
Clumpy structure in the debris disk around Vega has been previously reported at millimeter wavelengths and attributed to concentrations of dust grains trapped in resonances with an unseen planet. However, recent imaging at similar wavelengths with higher sensitivity has disputed the observed structure. We present three new millimeter wavelength observations that help to resolve the puzzling and contradictory observations. We have observed the
Vega system with the Submillimeter Array (SMA) at a wavelength of 880 μm and an angular resolution of 5"; with the Combined Array for Research in Millimeter-wave Astronomy (CARMA) at a wavelength of 1.3 mm and
an angular resolution of 5"; and with the Green Bank Telescope (GBT) at a wavelength of 3.3 mm and angular resolution of 10". Despite high sensitivity and short baselines, we do not detect the Vega debris disk in either of the
interferometric data sets (SMA and CARMA), which should be sensitive at high significance to clumpy structure based on previously reported observations. We obtain a marginal (3σ) detection of disk emission in the GBT data;
the spatial distribution of the emission is not well constrained.We analyze the observations in the context of several different models, demonstrating that the observations are consistent with a smooth, broad, axisymmetric disk with inner radius 20–100 AU and width ≾50 AU. The interferometric data require that at least half of the 860 μm emission detected by previous single-dish observations with the James Clerk Maxwell Telescope be distributed axisymmetrically, ruling out strong contributions from flux concentrations on spatial scales of ≾100 AU. These observations support recent results from the Plateau de Bure Interferometer indicating that previous detections of clumpy structure in the Vega debris disk were spurious
CARGC Briefs Volume I: ISIS Media
The essays that comprise CARGC Briefs Volume I: ISIS Media began their lives as presentations at a small, by-invitation workshop, “Emerging Work on Communicative Dimensions of Islamic State,” held on May 3-4, 2017 at the Center for Advanced Research in Global Communication at the Annenberg School for Communication.
Consistent with CARGC’s mission to mentor early-career scholars, the workshop was a non-public event featuring graduate students, some affiliated with the Jihadi Networks of Communication and CultureS (JINCS) research group at CARGC, and others from around the United States and the world, in addition to postdocs and faculty members. Parameters were purposefully broad to encourage independent thought and intellectual exploration: contributors were asked to write short essays focusing on any single aspect of Islamic State that was part of their research.
The result is a group of fascinating essays: using mostly primary sources (textual, visual, or audio-visual), examining several media platforms and modalities, considering multiple levels of theoretical deployment and construction, and shedding light on various aspects of Islamic State communication against the broad back drop of history, ideology and geopolitics, the following include some of the most innovative approaches to Islamic State to date, and promise a wave of fresh voices on one of the most important challenges to global order.https://repository.upenn.edu/cargc_briefs/1000/thumbnail.jp
Effects of Obesity And Insulin on Tissue-Specific Recycling Between Cortisol And Cortisone in Men
An Assessment of Current Fan Noise Prediction Capability
In this paper, the results of an extensive assessment exercise carried out to establish the current state of the art for predicting fan noise at NASA are presented. Representative codes in the empirical, analytical, and computational categories were exercised and assessed against a set of benchmark acoustic data obtained from wind tunnel tests of three model scale fans. The chosen codes were ANOPP, representing an empirical capability, RSI, representing an analytical capability, and LINFLUX, representing a computational aeroacoustics capability. The selected benchmark fans cover a wide range of fan pressure ratios and fan tip speeds, and are representative of modern turbofan engine designs. The assessment results indicate that the ANOPP code can predict fan noise spectrum to within 4 dB of the measurement uncertainty band on a third-octave basis for the low and moderate tip speed fans except at extreme aft emission angles. The RSI code can predict fan broadband noise spectrum to within 1.5 dB of experimental uncertainty band provided the rotor-only contribution is taken into account. The LINFLUX code can predict interaction tone power levels to within experimental uncertainties at low and moderate fan tip speeds, but could deviate by as much as 6.5 dB outside the experimental uncertainty band at the highest tip speeds in some case
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