Universitätsbibliotheken, digitale Medien und Mobilität – Reflexionen und Szenarien

Along with the development and prevalence of mobile communication technologies new infor-mation services as well as knowledge and communication cultures have emerged. Talking of mobile libraries gained new meanings in this context. In recent times, respective concepts and digital applications, e-books, and mobile library applications have been developed. Considerations re-garding historical connections of mobility and the development of libraries find attention rather at the sidelines. The same counts for more differentiated theoretical claims which have been devel-opend in media theory, knowledge theory and educational research. The contribution begins with some conceptual reflections on libraries and mobility, as well as some challenges in the age of digitization, followed by considerations of mobile developments and learning scenarios in the context of university libraries. Finally, examples of mobile learning / teaching scenarios are brought up for discussion

Universitätsbibliotheken, digitale Medien und Mobilität – Reflexionen und Szenarien

Along with the development and prevalence of mobile communication technologies new infor-mation services as well as knowledge and communication cultures have emerged. Talking of mobile libraries gained new meanings in this context. In recent times, respective concepts and digital applications, e-books, and mobile library applications have been developed. Considerations re-garding historical connections of mobility and the development of libraries find attention rather at the sidelines. The same counts for more differentiated theoretical claims which have been devel-opend in media theory, knowledge theory and educational research. The contribution begins with some conceptual reflections on libraries and mobility, as well as some challenges in the age of digitization, followed by considerations of mobile developments and learning scenarios in the context of university libraries. Finally, examples of mobile learning / teaching scenarios are brought up for discussion

Medication Review and Enhanced Information Transfer at Discharge of Older Patients with Polypharmacy: a Cluster-Randomized Controlled Trial in Swiss Hospitals

Background: Medication safety in patients with polypharmacy at transitions of care is a focus of the current Third WHO Global Patient Safety Challenge. Medication review and communication between health care professionals are key targets to reduce medication-related harm. Objective: To study whether a hospital discharge intervention combining medication review with enhanced information transfer between hospital and primary care physicians can delay hospital readmission and impact health care utilization or other health-related outcomes of older inpatients with polypharmacy. Design: Cluster-randomized controlled trial in 21 Swiss hospitals between January 2019 and September 2020, with 6 months follow-up. Participants: Sixty-eight senior physicians and their blinded junior physicians included 609 patients ≥ 60 years taking ≥ 5 drugs. Interventions: Participating hospitals were randomized to either integrate a checklist-guided medication review and communication stimulus into their discharge processes, or follow usual discharge routines. Main measures: Primary outcome was time-to-first-readmission to any hospital within 6 months, analyzed using a shared frailty model. Secondary outcomes covered readmission rates, emergency department visits, other medical consultations, mortality, drug numbers, proportions of patients with potentially inappropriate medication, and the patients' quality of life. Key results: At admission, 609 patients (mean age 77.5 (SD 8.6) years, 49.4% female) took a mean of 9.6 (4.2) drugs per patient. Time-to-first-readmission did not differ significantly between study arms (adjusted hazard ratio 1.14 (intervention vs. control arm), 95% CI [0.75-1.71], p = 0.54), nor did the 30-day hospital readmission rates (6.7% [3.3-10.1%] vs. 7.0% [3.6-10.3%]). Overall, there were no clinically relevant differences between study arms at 1, 3, and 6 months after discharge. Conclusions: The combination of a structured medication review with enhanced information transfer neither delayed hospital readmission nor improved other health-related outcomes of older inpatients with polypharmacy. Our results may help researchers in balancing practicality versus stringency of similar hospital discharge interventions. Study registration: ISRCTN18427377, https://doi.org/10.1186/ISRCTN18427377. Keywords: communication; health care quality improvement; hospital medicine; medication safety; primary care

Spezialisierung Medienpädagogik - ein neues Angebot für Lehramtsstudierende: Aufgabenbereiche und Tätigkeitsfelder der Absolvent*innen

Rufe nach mehr Medienkompetenz und Medienbildung in schulischen Kontexten werden inzwischen von vielen Seiten zunehmend deutlicher artikuliert. Mehr und mehr ist klar geworden, dass einseitige Perspektiven der technologischen Qualifizierung zu kurz greifen und differenzierende Perspektiven von Bildung und Kultur in medialisierten und digitalisierten Welten erforderlich sind, wenn in sinnvoller Weise von der Zukunft des Lernens die Rede sein soll. Welche konkreten Aufgabenfelder kommen auf Medienpädagog*innen in der Schule zu? Welche Relevanz hat ihre Arbeit für die Unterrichtsgestaltung, die Schulorganisation und die Entwicklung einer Schule? Die Überlegungen im Essay stehen im Zusammenhang mit einem neuen Studienangebot "Spezialisierung Medienpädagogik" für Lehramtsstudierende und verdeutlichen die Expertise der künftigen AbsolventInnen

Editorial 2/2014: Potenziale digitaler Medienkunst

Editorial 2/201

DESIGN AND ANALYSIS OF ROCKET NOZZLE

The nozzle is utilized to change over the compound warm vitality created in the ignition chamber into motor vitality. The spout changes over the low speed, high weight, high temperature gas in the ignition chamber into high speed gas of lower weight and temperature. Spout is a gadget intended to control the rate of stream, speed, heading, mass, shape, as well as the weight of the stream that fumes from them. Spouts arrive in an assortment of shapes and sizes relying upon the mission of the rocket, this is critical for the comprehension of the execution attributes of rocket. Joined dissimilar spout is the most normally utilized spout since in utilizing it the force can be warmed in burning chamber. In this theory examination is done to the focalized dissimilar spout by changing distinctive spout measurements and diverse liquids at various speeds. We displayed focalized dissimilar spout changing with various spout distances across and Analyzed the joined disparate spout with various mass stream rates to decide the weight drop, warm exchange coefficient, and speed and warmth exchange rate for the liquid by CFD strategy

Editorial 2/2015: Begründungen und Ziele der Medienbildung

Von Medienbildung ist in unterschiedlichen wissenschaftlichen, politischen, technologischen sowie alltagsweltlichen Diskurszusammenhängen die Rede. Dabei kommen ähnliche, zum Teil auch konträre Begriffsauffassungen und Zielvorstellungen zum Tragen, die mit unterschiedlichen Ansprüchen, Begründungsformen und Reichweiten korrespondieren

AKNA Frameshift Variant in Three Dogs with Recurrent Inflammatory Pulmonary Disease.

We investigated three related Rough Collies with recurrent inflammatory pulmonary disease. The clinical symptoms were similar to primary ciliary dyskinesia (PCD). However, the affected dogs did not carry any known pathogenic PCD variants. Pedigree analysis suggested a recessive mode of inheritance. Combined linkage and homozygosity mapping in three cases and seven non-affected family members delineated 19 critical intervals on 10 chromosomes comprising a total of 99 Mb. The genome of one affected dog was sequenced and compared to 601 control genomes. We detected only a single private homozygous protein-changing variant in the critical intervals. The detected variant was a 4 bp deletion, c.2717_2720delACAG, in the gene encoding the AT-hook transcription factor. It causes a frame-shift introducing a premature stop codon and truncates 37% of the open reading frame, p.(Asp906Alafs*173). We genotyped 88 Rough Collies consisting of family members and unrelated individuals. All three available cases were homozygous for the mutant allele and all 85 non-affected dogs were either homozygous wildtype ( = 67) or heterozygous ( = 18). AKNA modulates inflammatory immune responses. knockout mice die shortly after birth due to systemic autoimmune inflammatory processes including lung inflammation that is accompanied by enhanced leukocyte infiltration and alveolar destruction. The perfect genotype-phenotype association and the comparative functional data strongly suggest that the detected :c.2717_2720delACAG variant caused the observed severe airway inflammation in the investigated dogs. Our findings enable genetic testing, which can be used to avoid the unintentional breeding of affected puppies

The Effects of FGF4 Retrogenes on Canine Morphology

Two FGF4 retrogenes (FGF4L1 on chromosome 18 and FGF4L2 on chromosome 12) have been identified to cause dwarfism across many dog breeds. Some breeds are nearly homozygous for both retrogenes (e.g., Dachshunds) and others are homozygous for just one (e.g., Beagles and Scottish Terriers). Since most breeds do not segregate both of these retrogenes, it is challenging to evaluate their individual effects on long bone length and body size. We identified two dog breeds selected for hunting ability, the Alpine Dachsbracke and the Schweizer Niederlaufhund, that segregate both of these retrogenes. Using individual measurements of height at the shoulder, back length, head width, thorax depth and width, and thoracic limb measurements, we evaluated the combined effects of FGF4 retrogenes within these breeds. We applied multivariable linear regression analysis to determine the effects of retrogene copy numbers on the measurements. Copy numbers of both retrogenes had significant effects reducing height at the shoulders and antebrachial length, with FGF4L1 having a much greater effect than FGF4L2. FGF4L1 alone influenced the degree of carpal valgus and FGF4L2 alone increased head width. Neither retrogene had an effect on thorax width or depth. Selectively breeding dogs with FGF4L1 and without FGF4L2 would likely lead to a reduction in the FGF4L2-related risk of intervertebral disc herniation while maintaining the reduction in leg length resulting from FGF4L1