"Antiscepticism and Easy Justification" - Ch 5 of Seemings and Epistemic Justification

In this chapter I investigate epistemological consequences of the fact that seeming-based justification is elusive, in the sense that the subject can lose this justification simply by reflecting on her seemings. I argue that since seeming-based justification is elusive, the antisceptical bite of phenomenal conservatism is importantly limited. I also contend that since seeming-based justification has this feature, phenomenal conservatism isn’t actually afflicted by easy justification problems

Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation

Objective Mitochondrial disturbances of energy-generating systems in childhood are a heterogeneous group of disorders. The aim of this multi-site survey was to characterise the natural course of a novel mitochondrial disease with ATP synthase deficiency and mutation in the TMEM70 gene. Methods Retrospective clinical data and metabolic profiles were collected and evaluated in 25 patients (14 boys, 11 girls) from seven European countries with a c. 317-2A -> G mutation in the TMEM70 gene. Results Severe muscular hypotonia (in 92% of newborns), apnoic spells (92%), hypertrophic cardiomyopathy (HCMP; 76%) and profound lactic acidosis (lactate 5-36 mmol/l; 92%) with hyperammonaemia (100-520 mu mol/l; 86%) were present from birth. Ten patients died within the first 6 weeks of life. Most patients surviving the neonatal period had persisting muscular hypotonia and developed psychomotor delay. HCMP was non-progressive and even disappeared in some children. Hypospadia was present in 54% of the boys and cryptorchidism in 67%. Increased excretion of lactate and 3-methylglutaconic acid (3-MGC) was observed in all patients. In four surviving patients, life-threatening hyperammonaemia occurred during childhood, triggered by acute gastroenteritis and prolonged fasting. Conclusions ATP synthase deficiency with mutation in TMEM70 should be considered in the diagnosis and management of critically ill neonates with early neonatal onset of muscular hypotonia, HCMP and hypospadias in boys accompanied by lactic acidosis, hyperammonaemia and 3-MGC-uria. However, phenotype severity may vary significantly. The disease occurs frequently in the Roma population and molecular-genetic analysis of the TMEM70 gene is sufficient for diagnosis without need of muscle biopsy in affected children

Do looks constitute our perceptual evidence?

Contains fulltext : 225687pub.pdf (Publisher’s version ) (Open Access)16 september 202

"Phenomenal Conservatism" - Ch 2 of Seemings and Epistemic Justification

In this chapter I introduce and analyse the tenets of phenomenal conservatism, and discuss the problem of the nature of appearances. After that, I review the asserted epistemic merits phenomenal conservatism and the principal arguments adduced in support of it. Finally, I survey objections to phenomenal conservatism and responses by its advocates. Some of these objections will be scrutinised and appraised in the next chapters

Rubber friction: role of the flash temperature

When a rubber block is sliding on a hard rough substrate, the substrate asperities will exert time-dependent deformations of the rubber surface resulting in viscoelastic energy dissipation in the rubber, which gives a contribution to the sliding friction. Most surfaces of solids have roughness on many different length scales, and when calculating the friction force it is necessary to include the viscoelastic deformations on all length scales. The energy dissipation will result in local heating of the rubber. Since the viscoelastic properties of rubber-like materials are extremely strongly temperature dependent, it is necessary to include the local temperature increase in the analysis. At very low sliding velocity the temperature increase is negligible because of heat diffusion, but already for velocities of order 0.01 m/s the local heating may be very important. Here I study the influence of the local heating on the rubber friction, and I show that in a typical case the temperature increase results in a decrease in rubber friction with increasing sliding velocity for v > 0.01 m/s. This may result in stick-slip instabilities, and is of crucial importance in many practical applications, e.g., for the tire-road friction, and in particular for ABS-breaking systems.Comment: 22 pages, 27 figure

Realism, Objectivity, and Evaluation

I discuss Benacerraf's epistemological challenge for realism about areas like mathematics, metalogic, and modality, and describe the pluralist response to it. I explain why normative pluralism is peculiarly unsatisfactory, and use this explanation to formulate a radicalization of Moore's Open Question Argument. According to the argument, the facts -- even the normative facts -- fail to settle the practical questions at the center of our normative lives. One lesson is that the concepts of realism and objectivity, which are widely identified, are actually in tension

The Distance Scale of Planetary Nebulae

By collecting distances from the literature, a set of 73 planetary nebulae with mean distances of high accuracy is derived. This sample is used for recalibration of the mass-radius relationship, used by many statistical distance methods. An attempt to correct for a statistical peculiarity, where errors in the distances influences the mass--radius relationship by increasing its slope, has been made for the first time. Distances to PNe in the Galactic Bulge, derived by this new method as well as other statistical methods from the last decade, are then used for the evaluation of these methods as distance indicators. In order of achieving a Bulge sample that is free from outliers we derive new criteria for Bulge membership. These criteria are much more stringent than those used hitherto, in the sense that they also discriminate against background objects. By splitting our Bulge sample in two, one with optically thick (small) PNe and one with optically thin (large) PNe, we find that our calibration is of higher accuracy than most other calibrations. Differences between the two subsamples, we believe, are due to the incompleteness of the Bulge sample, as well as the dominance of optical diameters in the ``thin'' sample and radio diameters in the ``thick'' sample. Our final conclusion is that statistical methods give distances that are at least as accurate as the ones obtained from many individual methods. Also, the `long' distance scale of Galactic PNe is confirmed.Comment: 15 pages, 9 figures, accepted for publication in A&

Position Paper: Secure Infrastructure for Scientific Data Life Cycle Management

Abstract—Within the Austrian Grid project phase 2, three different groups, each allocated to a different workpackage, join their efforts to implement a grid infrastructure for the european research project “Breath Gas Analysis for molecular oriented diseases”. This position paper provides background on the task and the resulting requirements, a presentation on solutions developed during related projects in the application domain, identifies problems that have not yet been solved, and finally presents the intended solution to be developed. I. INTRODUCTION & CONTEXT This position paper describes the current state, the in-tended realisation and a discussion of the project Grid Breath Gas Analysis (BAMOD-Grid) carried out withi