NECESSIDADE DE TRATAMENTO ODONTOLÓGICO EM PACIENTES COM TRANSTORNO DO ESPECTRO AUTISTA

O Transtorno do Espectro Autista (TEA) exige demandas variadas na área da saúde, especialmente na odontologia, os indivíduos com TEA, normalmente, apresentam graus mais avançados da doença cárie e periodontal pela inadequada higiene oral e difícil manejo interferindo na saúde bucal. Objetivo: verificar o Índice Necessidade de Tratamento Odontológico (INTO) em indivíduos com TEA do município de Passo Fundo – RS. Método: a amostra é composta por 22 indivíduos de ambos os sexos com idades entre 6 e 14 anos, e diferentes graus de TEA. Resultados: 45% das crianças analisadas na pesquisa não necessitavam de tratamento odontológico, 40% tinham de 1 a 3 dentes com necessidade de tratamento e, 13% das crianças tinham de 4 a 8 dentes com necessidade de tratamento odontológico. Conclusão: as meninas apresentam uma saúde bucal geral melhor que os meninos, porém, quando necessitam de tratamento, as necessidades são mais complexas e em maior número; foram poucas as crianças com 4 a 8 dentes necessitando de tratamento odontológico, porém somadas com as crianças com 1 a 3 dentes necessitando de intervenção o número passa da metade das crianças do estudo (54%), ou seja, neste estudo mais da metade das crianças com TEA necessitam de alguma intervenção odontológica

Fine Mapping of the 1p36 Deletion Syndrome Identifies Mutation of PRDM16 as a Cause of Cardiomyopathy

Deletion 1p36 syndrome is recognized as the most common terminal deletion syndrome. Here, we describe the loss of a gene within the deletion that is responsible for the cardiomyopathy associated with monosomy 1p36, and we confirm its role in nonsyndromic left ventricular noncompaction cardiomyopathy (LVNC) and dilated cardiomyopathy (DCM). With our own data and publically available data from array comparative genomic hybridization (aCGH), we identified a minimal deletion for the cardiomyopathy associated with 1p36del syndrome that included only the terminal 14 exons of the transcription factor PRDM16 (PR domain containing 16), a gene that had previously been shown to direct brown fat determination and differentiation. Resequencing of PRDM16 in a cohort of 75 nonsyndromic individuals with LVNC detected three mutations, including one truncation mutant, one frameshift null mutation, and a single missense mutant. In addition, in a series of cardiac biopsies from 131 individuals with DCM, we found 5 individuals with 4 previously unreported nonsynonymous variants in the coding region of PRDM16. None of the PRDM16 mutations identified were observed in more than 6,400 controls. PRDM16 has not previously been associated with cardiac disease but is localized in the nuclei of cardiomyocytes throughout murine and human development and in the adult heart. Modeling of PRDM16 haploinsufficiency and a human truncation mutant in zebrafish resulted in both contractile dysfunction and partial uncoupling of cardiomyocytes and also revealed evidence of impaired cardiomyocyte proliferative capacity. In conclusion, mutation of PRDM16 causes the cardiomyopathy in 1p36 deletion syndrome as well as a proportion of nonsyndromic LVNC and DCM

Utilização de práticas integrativas na redução do estresse de pacientes felinos na consulta clínica: estudo de casos

O objetivo do presente trabalho foi relatar a utilização das técnicas supracitadas previamente à consulta clínica de felinos, bem como descrever a influência das práticas no comportamento dos pacientes atendidos

PELATIHAN PEMANFAATAN SAYUR ORGANIK DALAM PEMBUATAN SALAD SEHAT DI PANTI SANTO YUSUP SINDANGLAYA

Panti Asuhan Santo Yusup Sindanglaya merupakan panti yang menampung anak terlantar dengan memberikan tempat tinggal dan pendidikan. Panti Asuhan ini dikelola oleh Ordo Fransiskan yang juga mengembangkan area untuk kegiatan agrikultur yang terintegrasi dengan sekolah dan hunian panti. Panti asuhan ini berupaya memberikan berbagai pendidikan keterampilan untuk penghuni panti termasuk bertani, berternak dan juga keterampilan membangun. Sejalan dengan masalah yang ditemukan maka Fakultas Pariwisata memberikan suatu pelatihan bagaimana memanfaatkan sayur organik yang ada di Panti Asuhan Santo Yusup untuk diolah menjadi makanan salad sehat yang nantinya dapat dikembangkan sebagai peluang usaha dan diharapkan dapat meningkatkan ekonomi masyarakat sekitar serta bagaimana strategi pemasaran produk yang dihasilkan. Metode pengabdian yang dilaksanakan adalah dengan memberikan resep dan lokakarya pembuatan berbagai macam salad sayur dan percampurannya dengan bahan lain seperti buah dan sayur organik yang dihasilkan dari kebun di sekitar panti, serta mengenal strategi pemasaran yang dapat dilakukan. Diharapkan penghuni Panti Asuhan Santo Yusup dapat mengadopsi produk jasa yang telah diajarkan sehingga dapat bermanfaat dan meningkatkan pendapatan mitra dengan berwirausaha

"You don't want anyone who hasn't been through anything telling you what to do, because how do they know?": Qualitative analysis of case managers in a hospital-based violence intervention program.

Statement of purposeIntentional violent injury is a leading cause of disability and death among young adults in the United States. Hospital-based violence intervention programs (HVIPs), which strive to prevent re-injury through intensive case management, have emerged as a successful and cost-effective strategy to address this issue. Despite the importance of strong therapeutic relationships between clients and their case managers, specific case manager behaviors and attributes that drive the formation of these relationships have not been elucidated.MethodsA qualitative analysis with a modified grounded theory approach was conducted to gain insight into what clients perceive to be crucial to the formation of a strong client-case manager relationship. Twenty-four semi-structured interviews were conducted with prior clients of our hospital's HVIP. The interviews were analyzed using constant comparison method for recurrent themes.ResultsSeveral key themes emerged from the interviews. Clients emphasized that their case managers must: 1) understand and relate to their sociocultural contexts, 2) navigate the initial in-hospital meeting to successfully create connection, 3) exhibit true compassion and care, 4) serve as role models, 5) act as portals of opportunity, and 6) engender mutual respect and pride.ConclusionsThis study identifies key behaviors of case managers that facilitate the formation of strong therapeutic relationships at the different stages of client recovery. This study's findings emphasize the importance of case managers being culturally aligned with and embedded in their clients' communities. This work can provide a roadmap for case managers to form optimally effective relationships with clients

Outcome of in- and out-of-hospital cardiac arrest survivors with liver cirrhosis

Abstract Background Organ failure increases mortality in patients with liver cirrhosis. Data about resuscitated cardiac arrest patients with liver cirrhosis are missing. This study aims to assess aetiology, survival and functional outcome in patients after successful cardiopulmonary resuscitation (CPR) with and without liver cirrhosis. Methods Analysis of prospectively collected cardiac arrest registry data of consecutively hospital-admitted patients following successful CPR was performed. Patient’s characteristics, admission diagnosis, severity of disease, course of disease, short- and long-term mortality as well as functional outcome were assessed and compared between patients with and without cirrhosis. Results Out of 1068 patients with successful CPR, 47 (4%) had liver cirrhosis. Acute-on-chronic liver failure (ACLF) was present in 33 (70%) of these patients on admission, and four patients developed ACLF during follow-up. Mortality at 1 year was more than threefold increased in patients with liver cirrhosis (OR 3.25; 95% CI 1.33–7.96). Liver cirrhosis was associated with impaired neurological outcome (OR for a favourable cerebral performance category: 0.13; 95% CI 0.04–0.36). None of the patients with Child–Turcotte–Pugh (CTP) C cirrhosis survived 28 days with good neurological outcome. Overall nine (19%) patients with cirrhosis survived 28 days with good neurological outcome. All patients with ACLF grade 3 died within 28 days. Conclusion Cardiac arrest survivors with cirrhosis have worse outcome than those without. Although one quarter of patients with liver cirrhosis survived longer than 28 days after successful CPR, patients with CTP C as well as advanced ACLF did not survive 28 days with good neurological outcome

MOESM1 of Outcome of in- and out-of-hospital cardiac arrest survivors with liver cirrhosis

Additional file 1: Table S1. Routine laboratory on admission. Table S2. Characteristics of cirrhotic patients with and without mild therapeutic hypothermia. Table S3. CPR-specific data according to in- and out-hospital cardiac arrest