Исследование процесса электронно-лучевой наплавки нержавеющей проволокой в условиях аддитивных технологий

Объектом исследования является наплавленные образцы, полученные методом электронно-лучевого наплавления в условиях аддитивных технологий. Цель работы – рассмотрение микроструктуры и измерение микротвердости нержавеющих образцов марки AISI 308L (ГОСТ 08Х18Н10Т) и 40Х13. В ходе исследования рассматривались образцы, полученные методом электронно-лучевого наплавления. В качестве основного материала выступали нержавеющие стали марки AISI 308L (ГОСТ 08Х18Н10Т) и 40Х13. Исследование макроструктуры образцов и измерение микротвердости производились при помощи светового микроскопа Axio Observer A1.m и микротвердомера DuraScan.The object of the study is the deposited samples obtained by the electron beam direction method under the conditions of additive technologies. The purpose of the work is to consider the microstructure and measure the microhardness of stainless samples of the AISI 308L (ГОСТ 08X18H10T) and 40X13 grades. In the course of the study, samples obtained by the electron beam direction method were considered. The main material was stainless steel AISI 308L (ГОСТ 08X18H10T) and 40X13. The macrostructure of the samples and the microhardness were studied using an Axio Observer A1.m light microscope and a DuraScan microhardness meter

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

Tiina Paunio on työryhmän UK10K jäsen.The analysis of individuals with ciliary chondrodysplasias can shed light on sensitive mechanisms controlling ciliogenesis and cell signalling that are essential to embryonic development and survival. Here we identify TCTEX1D2 mutations causing Jeune asphyxiating thoracic dystrophy with partially penetrant inheritance. Loss of TCTEX1D2 impairs retrograde intraflagellar transport (IFT) in humans and the protist Chlamydomonas, accompanied by destabilization of the retrograde IFT dynein motor. We thus define TCTEX1D2 as an integral component of the evolutionarily conserved retrograde IFT machinery. In complex with several IFT dynein light chains, it is required for correct vertebrate skeletal formation but may be functionally redundant under certain conditions.Peer reviewe

Разработка технологии сборки и сварки запорной арматуры для установки в магистральный газопровод диаметром 1020 мм

Актуальность работы: в данной выпускной квалификационной работе производится проектирование оснастки и участка сборки-сварки запорной арматуры для установки в магистральный газопровод диаметром 1020 мм. Объектом исследования является процесс изготовления запорной арматуры. Цели и задачи исследования (работы). В результате данной работы следует получить производство с наибольшей степенью механизации и автоматизации повышающей производительность труда. Работа представлена введением, пятью разделами (главами) и заключением, приведен список использованных источников. В 1 разделе/главе «Обзор литературы» произведен обзор литературы. Во 2 разделе/главе «Объект и методы исследования» Произведена формулировка проектной задачи и теоретический анализ. В 3 разделе/главе «Результаты проведенного исслеRelevance of the work: in the final qualifying work is done tooling design and site assembly welding KS-5871 frame. The object of research is the process of making the frame. The aims and objectives of the study (work). As a result of this work should be obtained from producing the greatest degree of mechanization and automation increases productivity. The work provides an introduction, five sections (chapters) and conclusion, a list of sources used. In one section / chapter "Literature Review" produced a literature review. In the 2nd section / chapter "Object and Methods" Produced formulation of project objectives and theoretical analysis. In Section 3 / Chapter "The results of the study" Made engineering calculation, considered design, technological and organizational part, examined th

In vivo actions of aripiprazole on serotonergic and dopaminergic systems in rodent brain

[Rationale]: Aripiprazole is an atypical antipsychotic drug with high in vitro affinity for 5-HT1A, 5-HT2A and dopamine (DA) D2 receptors. However, its in vivo actions in the brain are still poorly characterized.[Objective]: The aim was to study the in vivo actions of aripiprazole in the rat and mouse brain.[Methods]: Brain microdialysis and single-unit extracellular recordings were performed.[Results]: The systemic administration of aripiprazole reduced 5-HT output in the medial prefrontal cortex (mPFC) and dorsal raphe nucleus of the rat. Aripiprazole also reduced extracellular 5-HT in the mPFC of wild-type (WT) but not of 5-HT1A (−/−) knockout (KO) mice. Aripiprazole reversed the elevation in extracellular 5-HT output produced by the local application of the 5-HT2A/2C receptor agonist DOI in mPFC. Aripiprazole also increased the DA output in mPFC of WT but not of 5-HT1A KO mice, as observed for atypical antipsychotic drugs, in contrast to haloperidol. Contrary to haloperidol, which increases the firing rate of DA neurons in the ventral tegmental area (VTA), aripiprazole induced a very moderate reduction in dopaminergic activity. Haloperidol fully reversed the inhibition in dopaminergic firing rate induced by apomorphine, whereas aripiprazole evoked a partial reversal that was significantly different from that evoked by haloperidol and from the spontaneous reversal of dopaminergic activity in rats treated with apomorphine.[Conclusions]: These results indicate that aripiprazole modulates the in vivo 5-HT and DA release in mPFC through the activation of 5-HT1A receptors. Moreover, aripiprazole behaves as a partial agonist at DA D2 autoreceptors in vivo, an action which clearly distinguishes it from haloperidol.This work was supported by grants from the Spanish Ministry of Education and Science (SAF 2004-05525) and Bristol Myers Squibb. PC and AB are recipients of a Ramón y Cajal contract from the Ministry of Science and Technology. LDM is recipient of a predoctoral fellowship from IDIBAPS. Support from the Spanish Ministry of Health, Instituto de Salud Carlos III, Red de Enfermedades Mentales (REM-TAP Network) is also acknowledged.Peer reviewe