New approach to evaluate the TOWS matrix and its application in a mining company

SWOT analyses and the closely related TOWS matrix are frequent starting points for an organization to develop its strategy. The paper deals with the evaluation of the TOWS matrix and presents three novel approaches to evaluate the different factors of the TOWS matrix, namely (1) approach to evaluate the factors with identical weights; (2) approach to evaluate factors with their weights determined within the different quadrants of the TOWS matrix; and (3) approach to evaluate factors with weights determined within the whole TOWS matrix. The third approach has two variants. The proposed approaches to evaluate the TOWS matrix were tested on a SWOT analysis of a significant mining company in the Czech Republic. The results imply that the strategy W-T (weaknesses-threats) is recommended in three cases, while the strategy S-T (strengths-threats) is recommended once. The paper may be valuable for managers responsible for strategic planning.Web of Science118121303129

Position and Independence of a Central Bank

Import 04/07/2011Cílem bakalářské práce "Postavení a nezávislost centrální banky" je zhodnocení stupně nezávislosti České národní banky při jejím založení a v současnosti a dále komparace nezávislosti centrálních bank Spojených států amerických, Japonska a Evropské unie v kontextu nezávislosti České národní banky. První část práce je zaměřena na teoretické objasnění postavení a nezávislosti centrální banky a na způsoby jejího měření, druhá se zabývá vývojem a hodnocením nezávislosti České národní banky a třetí hodnotí míru nezávislosti vybraných centrálních bank a zaměřuje se na jejich nedostatky.The thesis status and independence of central banks is to evaluate the degree of independence of the Czech National Bank in its formation and now and then to compare of central bank independence of the United States, Japan and the European Union in the context of the independence of the Czech National Bank. The first part focuses on theoretical clarification of the status and independence of the central bank and its method of measurement, the second deals with the development and evaluation of the independence of the Czech National Bank, and the third evaluates the degree of independence from selected central banks, focusing on their weaknesses.156 - Katedra národohospodářskávýborn

Educational gradients in all-cause mortality in two cohorts in the Czech Republic during the early stage of the postcommunist transition

Objectives: We investigated whether social gradient in all-cause mortality in the Czech Republic changed during the postcommunist transition by comparing two cohorts, recruited before and after the political changes in 1989. Methods: Participants (aged 25–64 years) in two population surveys (n=2530 in 1985, n=2294 in 1992) were followed up for mortality for 15 years (291 and 281 deaths, respectively). Education was classified into attainment categories and years of schooling (both continuous and in tertiles). Cox regression was used to estimate HR of death by educational indices in each cohort over a 15-year follow-up. Results: All three educational variables were significantly associated with reduced risk of death in both cohorts when men and women were combined; for example, the adjusted HRs of death in the highest versus lowest tertile of years of schooling were 0.65 (95% CI 0.47 to 0.89) in 1985 and 0.67 (95% CI 0.48 to 0.93) in 1992. Adjustment for covariates attenuated the gradients. In sex-specific analysis, the gradient was more pronounced and statistically significant in men. There were no significant interactions between cohort and educational indices. Conclusions: The educational gradient in mortality did not differ between the two cohorts (1985 vs 1992), suggesting no major increase in educational inequality during the early stage of postcommunist transition. Further research is needed to understand trends in health inequalities during socioeconomic transitions

Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?

Background: Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), produced by endotoxin-activated Kupffer cells, play a key role in the pathogenesis of alcoholic liver cirrhosis (ALC). Alleles TNFA -238A, IL1B -31T and variant IL1RN*2 of repeat polymorphism in the gene encoding the IL-1 receptor antagonist increase production of TNF-α and IL-1β, respectively. Alleles CD14 -159T, TLR4 c.896G and TLR4 c.1196T modify activation of Kupffer cells by endotoxin. We confirmed the published associations between these common variants and genetic predisposition to ALC by means of a large case-control association study conducted on two Central European populations. Methods: The study population comprised a Czech sample of 198 ALC patients and 370 controls (MONICA project), and a German sample of 173 ALC patients and 331 controls (KORA-Augsburg), and 109 heavy drinkers without liver disease. Results: Single locus analysis revealed no significant difference between patients and controls in all tested loci. Diplotype [IL1RN*2/*2; IL1B -31T+] was associated with increased risk of ALC in the pilot study, but not in the validation samples. Conclusions: Although cytokine mediated immune reactions play a role in the pathogenesis of ALC, hereditary susceptibility caused by variants in the corresponding genes is low in Central European populations. Clin Chem Lab Med 2009;47:398-40

DNA methylation profiles in a group of workers occupationally exposed to nanoparticles

The risk of exposure to nanoparticles (NPs) has rapidly increased during the last decade due to the vast use of nanomaterials (NMs) in many areas of human life. Despite this fact, human biomonitoring studies focused on the effect of NP exposure on DNA alterations are still rare. Furthermore, there are virtually no epigenetic data available. In this study, we investigated global and gene-specific DNA methylation profiles in a group of 20 long-term (mean 14.5 years) exposed, nanocomposite, research workers and in 20 controls. Both groups were sampled twice/day (pre-shift and post-shift) in September 2018. We applied Infinium Methylation Assay, using the Infinium MethylationEPIC BeadChips with more than 850,000 CpG loci, for identification of the DNA methylation pattern in the studied groups. Aerosol exposure monitoring, including two nanosized fractions, was also performed as proof of acute NP exposure. The obtained array data showed significant differences in methylation between the exposed and control groups related to long-term exposure, specifically 341 CpG loci were hypomethylated and 364 hypermethylated. The most significant CpG differences were mainly detected in genes involved in lipid metabolism, the immune system, lung functions, signaling pathways, cancer development and xenobiotic detoxification. In contrast, short-term acute NP exposure was not accompanied by DNA methylation changes. In summary, long-term (years) exposure to NP is associated with DNA epigenetic alterations

Financial Analysis of the Company, ČD Cargo a.s.

Import 02/11/2016Diplomová práce se zabývá finanční analýzou společnosti ČD Cargo a.s. Práce je rozdělena na dvě hlavní části a to teoretickou část, která se zabývá charakteristikou výše uvedené společnosti a teoretickým vymezením finanční analýzy. V charakteristice společnosti jsou popsány základní údaje, historie, organizační struktura a služby zákazníkům. Teoretické vymezení finanční analýzy se věnuje problematice zdrojů dat pro tvorbu finanční analýzy, horizontální a vertikální analýzou, skupinou poměrových ukazatelů a v neposlední řadě také Du-point pyramidálním rozkladem a bonitními a bankrotními modely. Praktická část diplomové práce obsahuje již samotnou finanční analýzu společnosti ČD Cargo a.s.The diploma’s thesis follows up the financial analysis of the Company, ČD Cargo a.s. Thesis is divided into two main parts, which are: the theoretical parts which deals with the characteristics of the above company and theoretical definition of financial analysis. The characteristic of the company describes the basic data, history, organizational structure and customer service. Theoretical definition of financial analysis is devoted to data sources for the creation of financial analysis, horizontal and vertical analysis, group ratios and, ultimately, Du-point pyramidal decomposition and bonit and bankruptcy models. The practical part contains financial analysis of the company ČD Cargo a.s.Prezenční545 - Institut ekonomiky a systémů řízenívýborn

Soziolekte und Stilistik

In seinem Artikel beschäftigt sich der Verfasser mit der stilistischen Funktion von sozial motivierten Ausdrücken (Soziolektismen), die er traditionell in Ausdrücke aus dem beruflichen Bereich, Slang- und Argotausdrücke einteilt. Dabei versucht er, die Grenze zwischen den Ausdrücken aus dem beruflichen Bereich und den Slangausdrücken festzusetzen. Weiter widmet er seine Aufmerksamkeit den möglichen stilistischen Merkmalen des Alters, der Emotionalität (Expressivität) und der Bildung von Soziolektismen. Seine Ausführungen belegt er mit manchen Beispielen aus verschiedenen Fach- und Interessenmilieus

Unemployment of graduates of secondary schools and universities in the region focused on the mining industry

Import 05/08/2014Bakalářská práce se zabývá nezaměstnaností absolventů středních a vysokých škol v regionech zaměřených na těžební průmysl. Práce je rozdělena na dvě hlavní části a to teoretickou část, ve které jsou vymezeny základní pojmy, typy nezaměstnaností, vývoj míry nezaměstnanosti a charakteristiky oblastí zaměřené na těžební průmysl. V Moravskoslezském kraji se jedná se zejména o oblast Ostravska a Karvinska, v Ústeckém kraji o oblast Mostecka a v Karlovarském kraji o oblast Sokolovska. Praktická část práce se zabývá analýzou nezaměstnanosti absolventů středních a vysokých škol v těchto krajích a porovnává stav nezaměstnanosti s celorepublikovým průměrem.The bachelor`s thesis follows up the unemployment of the high schools and universities graduates in the regions focused on the mining industry. Thesis is divided into two main parts, which are: the theoretical part, where the keywords, the types of the unemployment, the development of the unemployment rate and the characteristics of the regions focused on the mining industry are defined. In the Moravskoslezský kraj it is mainly the Ostrava and Karviná region, in the Ústecký kraj it is the Most region and in the Karlovarský kraj, it is the Sokolov region. The practical part follows up the analysis of the unemployment of the high schools and universities graduates in these regions and compares the state of the unemployment with the national average.Prezenční545 - Institut ekonomiky a systémů řízenívýborn

Analysis of Causes of Changes in the Quarries Economic Results.

Podnikání v báňském průmyslu má řadu specifických rysů, které se nevyskytují v jiných průmyslových oborech. Je investičně náročné, musí vycházet z přírodních podmínek určujících množství a kvalitu nerostné suroviny, je časově omezené, závisí na výši zásob, intenzitě těžby. Existuje malá možnost změny sortimentu produkce, kromě pozitivních přínosů pro ekonomiku státu má i řadu negativních faktorů. Předkládaná disertační práce „Analýza příčin změn hospodářského výsledku lomů“ se zabývá hledáním klíčových faktorů, které mají vliv na výsledek hospodaření lomových provozů.The mining industry business has a number of specific features that do not occur in other industries. It is investment-intensive, it must be based on natural conditions determining the quantity and quality of the mineral, it is limited in time, it depends on the amount of the reserves, the intensity of mining. There is little possibility of changing the product range, in addition to the positive benefits for the state's economy, it has a number of negative factors. The presented dissertation "Analysis of the causes of changes in the economic results of quarries" deals with the search for key factors that influence the result of quarry operations.545 - Katedra ekonomiky a systémů řízenívyhově