EFFECTS OF HEALTH EDUCATION BASED ON OMAHA SYSTEM ON ANXIETY, DEPRESSION AND SELF-MANAGEMENT ABILITY OF PRIMIPARA

Background: Primiparas are prone to tension, anxiety, depression and other emotions due to their lack of experience related to delivery and fear of the unknown during pregnancy. Meanwhile, their self-management ability decreases because of their failure to immediately adapt to the transformation of their roles in a short time. A nursing model was constructed in this study based on the combination of the Omaha System with PBL health education to examine the effect of this model on the anxiety, depression, quality of life and self-management ability of primiparas. Subjects and methods: From January to December 2020, 170 primiparas were recruited as volunteers in this study by means of voluntary registration. They were randomly divided into the observation group and the control group, with 85 members in each group. The intervention lasted 6 weeks. SDS, SAS, WHOQOL-BREF scale and ESCA scale were used to compare the scores of the two groups before and after the intervention. Results: (1) After the intervention, the changes of the observation group in self-management ability and its four dimensions are higher than those of the control group, with the differences being statistically significant (P<0.05). (2) After the intervention, the changes of the observation group in quality of life and its four dimensions are higher than those of the control group, with the differences being statistically significant (P<0.05). (3) The changes of the observation group in anxiety and depression are higher than those of the control group. Specifically, the change of the observation group in anxiety before and after the intervention is 6.40+5.61, in comparison with 2.67+3.71 in the control group; the change of the observation group in depression before and after the intervention is 9.07+8.42 in comparison with 3.19+7.06 in the control group. Conclusion: the new nursing method proposed in this study effectively improves the self-management ability and quality of life of primiparas, significantly reduces their anxiety and depression, has a high application value in obstetric nursing and also provides a new idea for the implementation of scientific and efficient nursing for primiparas

Linking supply chain quality integration with mass customization and product modularity

Supply chain quality management has received increasing attention from researchers and practitioners in recent years. However, the knowledge about the effects of a manufacturer's design and production capabilities on supply chain quality management is limited. In this study, we propose a model to investigate the effects of mass customization and product modularity on supply chain quality integration (i.e. internal, supplier, and customer quality integration) and the impact of supply chain quality integration on competitive performance. We use data collected from 317 global manufacturers to empirically test the conceptual model. The results show that mass customization and product modularity directly improve internal quality integration, and product modularity also improves internal quality integration indirectly through mass customization. Product modularity improves supplier quality integration directly, and both mass customization and product modularity improve supplier quality integration indirectly through internal quality integration. Mass customization improves customer quality integration both directly and indirectly through internal quality integration, and product modularity improves customer quality integration indirectly through mass customization and internal quality integration. We also find that supplier quality integration directly enhances competitive performance, and internal quality integration enhances competitive performance both directly and indirectly through supplier quality integration. Our findings contribute to production and quality management literature and practices

Characterization, phylogeny, alternative splicing and expression of Sox30 gene

<p>Abstract</p> <p>Background</p> <p>Members of the Sox gene family isolated from both vertebrates and invertebrates have been proved to participate in a wide variety of developmental processes, including sex determination and differentiation. Among these members, <it>Sox30 </it>had been considered to exist only in mammals since its discovery, and its exact function remains unclear.</p> <p>Results</p> <p><it>Sox30 </it>cDNA was cloned from the Nile tilapia by RT-PCR and RACE. Screening of available genome and EST databases and phylogenetic analysis showed that <it>Sox30 </it>also exists in non-mammalian vertebrates and invertebrates, which was further supported by synteny analyses. Tissue expression in human, mouse and tilapia suggested that <it>Sox30 </it>was probably a gonad-specific gene, which was also supported by the fact that <it>Sox30 </it>EST sequences were obtained from gonads of the animal species. In addition, four alternatively spliced isoforms were isolated from tilapia gonad. Their temporal and spatial expression patterns during normal and sex reversed gonadal development were investigated by RT-PCR and <it>in situ </it>hybridization. Our data suggest that expressions of <it>Sox30 </it>isoforms are related to stage and phenotypic-sex, observed in the germ cells of male gonad and in somatic cells of the female gonad.</p> <p>Conclusions</p> <p><it>Sox30 </it>is not a gene only existed in mammals, but exists widely throughout the animal kingdom as supported by our bioinformatic, phylogenetic and syntenic analyses. It is very likely that <it>Sox30 </it>is expressed exclusively in gonads. Expression analyses revealed that <it>Sox30 </it>may be involved in female and male gonadal development at different stages by alternative splicing.</p

Identifying veraison process of colored wine grapes in field conditions combining deep learning and image analysis

Acknowledgments This work was supported by the National Key R&D Program Project of China (Grant No. 2019YFD1002500) and Guangxi Key R&D Program Project (Grant No. Gui Ke AB21076001) The authors would like to thank the anonymous reviewers for their helpful comments and suggestions.Peer reviewedPostprin

Network Pharmacology Based Research on the Combination Mechanism Between Escin and Low Dose Glucocorticoids in Anti-rheumatoid Arthritis

Rheumatoid arthritis (RA) is characterized by chronic progressive symmetrical synovitis and destruction of multiple joints. Glucocorticoids (GCs) are widely used in the treatment of RA. However, their adverse effects can be serious. Escin, which is isolated from Aesculus hippocastanum L., has been reported to have anti-inflammatory effects. We investigated the anti-RA effect of Escin combined with low dose GCs (dexamethasone, Dex) and the underlying mechanism. Adjuvant-induced RA rats and lipopolysaccharides (LPS)-injured RAW264.7 cells were used to investigate the anti-RA effects of Escin combined with low dose Dex in vivo and in vitro. The results showed that Escin combined with low-dose Dex significantly decreased arthritic index, serum IL-6 and TNF-α levels, reduced paw swelling, and ameliorated the joint pathology and immune organ pathology. Gene chip results revealed that Nr3c1 (GR) expression was significantly altered, and that GR was activated by Escin and low dose Dex in vivo and in vitro. Additionally, Escin combined with low dose Dex also significantly increased GR mRNA expression. However, when GR expression was suppressed by its specific inhibitor, the anti-RA effect of Escin combined with low-dose Dex was abolished. The data in this study demonstrated that Escin combined with Dex reduced the dose of Dex, and exerted significant anti-RA effects, which could also reduce the adverse effects of Dex. This combination might result from GR activation. This study might provide a new combination of drugs for the treatment of RA

Performance-based earthquake engineering methodology for seismic analysis of nuclear cable tray system

The Pacific Earthquake Engineering Research (PEER) Center has been developing a performance-based earthquake engineering (PBEE) methodology, which is based on explicit determination of performance, e.g., monetary losses, in a probabilistic manner where uncertainties in earthquake ground motion, structural response, damage estimation, and losses are explicitly considered. To carry out the PEER PBEE procedure for a component of the nuclear power plant (NPP) such as the cable tray system, hazard curve and spectra were defined for two hazard levels of the ground motions, namely, operation basis earthquake, and safe shutdown earthquake. Accordingly, two sets of spectral compatible ground motions were selected for dynamic analysis of the cable tray system. In general, the PBEE analysis of the cable tray in NPP was introduced where the resulting floor motions from the time history analysis (THA) of the NPP structure should be used as the input motion to the cable tray. However, for simplicity, a finite element model of the cable tray was developed for THA under the effect of the selected ground motions. Based on the structural analysis results, fragility curves were generated in terms of specific engineering demand parameters. Loss analysis was performed considering monetary losses corresponding to the predefined damage states. Then, overall losses were evaluated for different damage groups using the PEER PBEE methodology

Multiple Magnetic Foreign Bodies Causing Severe Digestive Tract Injuries in a Child

Foreign body (FB) ingestion is a common emergency as well as a major cause of accidental injury and represents a severe public health problem in childhood, especially in infants. Most cases of FB ingestion reported in children aged between 6 months and 3 years depend primarily on the fact that young children are more likely to explore objects using their mouth and are not able to distinguish edible objects from nonedible ones, their teeth are physiologically lacking, and they have poor swallowing coordination. Although, sometimes it can cause serious complications, FB ingestion generally has a low mortality rate. However, accidental ingestion of magnetic toys, as a rare kind of FB mostly encountered in children, has now become more common due to the increased availability of objects and toys with magnetic elements. The majority of magnetic FB traverse the gastrointestinal (GI) system spontaneously without complication, but in rare cases may cause severe damages to the GI tract due to its special pathogenesis [Kay and Wyllie: Curr Gastroenterol Rep 2005;7: 212–218]. Ingestion of multiple magnets may be related to increased morbidity resulting in a delay of recognition of FB injury that can lead to serious complications and require surgical resolution