4,734 research outputs found
Markerless navigation system for orthopaedic knee surgery: a proof of concept study
Current computer-assisted surgical navigation systems mainly rely on optical markers screwed into the bone for anatomy tracking. The insertion of these percutaneous markers increases operating complexity and causes additional harm to the patient. A markerless tracking and registration algorithm has recently been proposed to avoid anatomical markers for knee surgery. The femur points were directly segmented from the recorded RGBD scene by a neural network and then registered to a pre-scanned femur model for the real-time pose. However, in a practical setup such a method can produce unreliable registration results, especially in rotation. Furthermore, its potential application in surgical navigation has not been demonstrated. In this paper, we first improved markerless registration accuracy by adopting a bounded-ICP (BICP) technique, where an estimate of the remote hip centre, acquired also in a markerless way, was employed to constrain distal femur alignment. Then, a proof-of-concept markerless navigation system was proposed to assist in typical knee drilling tasks. Two example setups for global anchoring were proposed and tested on a phantom leg. Our BICP-based markerless tracking and registration method has better angular accuracy and stability than the original method, bringing our straightforward, less invasive markerless navigation approach one step closer to clinical application. According to user tests, our proposed optically anchored navigation system achieves comparable accuracy with the state-of-the-art (3.64± 1.49 mm in position and 2.13±0.81° in orientation). Conversely, our visually anchored, optical tracker-free setup has a lower accuracy (5.86± 1.63 mm in position and 4.18±1.44° in orientation), but is more cost-effective and flexible in the operating room
Vaccination Coverage and Prevalence of Contagious Bovine Pleuropneumonia (1999 - 2008) in Two Transboundary States of North-Western Nigeria
Nigerian Veterinary Journal, Vol. 32(3): 2011; 169 - 17
Geometric phase outside a Schwarzschild black hole and the Hawking effect
We study the Hawking effect in terms of the geometric phase acquired by a
two-level atom as a result of coupling to vacuum fluctuations outside a
Schwarzschild black hole in a gedanken experiment. We treat the atom in
interaction with a bath of fluctuating quantized massless scalar fields as an
open quantum system, whose dynamics is governed by a master equation obtained
by tracing over the field degrees of freedom. The nonunitary effects of this
system are examined by analyzing the geometric phase for the Boulware, Unruh
and Hartle-Hawking vacua respectively. We find, for all the three cases, that
the geometric phase of the atom turns out to be affected by the space-time
curvature which backscatters the vacuum field modes. In both the Unruh and
Hartle-Hawking vacua, the geometric phase exhibits similar behaviors as if
there were thermal radiation at the Hawking temperature from the black hole.
So, a measurement of the change of the geometric phase as opposed to that in a
flat space-time can in principle reveal the existence of the Hawking radiation.Comment: 14 pages, no figures, a typo in the References corrected, version to
appear in JHEP. arXiv admin note: text overlap with arXiv:1109.033
Thermodynamical Consistent Modeling and Analysis of Nematic Liquid Crystal Flows
The general Ericksen-Leslie system for the flow of nematic liquid crystals is
reconsidered in the non-isothermal case aiming for thermodynamically consistent
models. The non-isothermal model is then investigated analytically. A fairly
complete dynamic theory is developed by analyzing these systems as quasilinear
parabolic evolution equations in an -setting. First, the existence of
a unique, local strong solution is proved. It is then shown that this solution
extends to a global strong solution provided the initial data are close to an
equilibrium or the solution is eventually bounded in the natural norm of the
underlying state space. In these cases, the solution converges exponentially to
an equilibrium in the natural state manifold
Recommended from our members
Evidence of a structural quantum critical point in (CaxSr1-x)3Rh4Sn13 from a lattice dynamics study
Approaching a quantum critical point (QCP) has been an effective route to
stabilize superconductivity. While the role of magnetic QCPs has been
extensively discussed, similar exploration of a structural QCP is scarce due to
the lack of suitable systems with a continuous structural transition that can
be conveniently tuned to 0~K. Using inelastic X-ray scattering, we examine the
phonon spectrum of the nonmagnetic quasi-skutterudite
(CaSr)RhSn, which represents a precious system to
explore the interplay between structural instabilities and superconductivity by
tuning the Ca concentration . We unambiguously detect the softening of
phonon modes around the M point on cooling towards the structural transition.
Intriguingly, at , the soft mode energy squared at the M point
extrapolates to zero at ~K, providing the first compelling
microscopic evidence of a structural QCP in
(CaSr)RhSn. The enhanced phonon density-of-states
at low energy provides the essential ingredient for realizing strong-coupling
superconductivity near the structural QCP
Clinical-pathological study on β-APP, IL-1β, GFAP, NFL, Spectrin II, 8OHdG, TUNEL, miR-21, miR-16, miR-92 expressions to verify DAI-diagnosis, grade and prognosis
Traumatic brain injury (TBI) is one of the most important death and disability cause, involving substantial costs, also in economic terms, when considering the young age of the involved subject. Aim of this paper is to report a series of patients treated at our institutions, to verify neurological results at six months or survival; in fatal cases we searched for βAPP, GFAP, IL-1β, NFL, Spectrin II, TUNEL and miR-21, miR-16, and miR-92 expressions in brain samples, to verify DAI diagnosis and grade as strong predictor of survival and inflammatory response. Concentrations of 8OHdG as measurement of oxidative stress was performed. Immunoreaction of β-APP, IL-1β, GFAP, NFL, Spectrin II and 8OHdG were significantly increased in the TBI group with respect to control group subjects. Cell apoptosis, measured by TUNEL assay, were significantly higher in the study group than control cases. Results indicated that miR-21, miR-92 and miR-16 have a high predictive power in discriminating trauma brain cases from controls and could represent promising biomarkers as strong predictor of survival, and for the diagnosis of postmortem traumatic brain injury
Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers
Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine threonine kinase belonging to the PIKK family (phosphoinositide 3-kinase-like-family of protein kinase), is a critical component of the non-homologous end joining (NHEJ) pathway required for the repair of DNA double strand breaks. DNA-PKcs may be involved in breast cancer pathogenesis. Methods: We evaluated clinicopathological significance of DNA-PKcs protein expression in 1161 tumours and DNA-PKcs mRNA expression in 1950 tumours. We correlated DNA-PKcs to other markers of aggressive phenotypes, DNA repair, apoptosis and cell cycle regulation. Results: Low DNA-PKcs protein expression was associated with higher tumour grade, higher mitotic index, tumour de-differentiation and tumour type (ps<0.05). Absence of BRCA1, low XRCC1/SMUG1/APE1/Polβ were also more likely in low DNA-PKcs expressing tumours (ps<0.05). Low DNA-PKcs protein expression was significantly associated with worse breast cancer specific survival (BCCS) in univariate and multivariate analysis (ps<0.01). At the mRNA level, low DNA-PKcs was associated with PAM50.Her2 and PAM50.LumA molecular phenotypes (ps<0.01) and poor BCSS. In patients with ER positive tumours who received endocrine therapy, low DNA-PKcs (protein and mRNA) was associated with poor survival. In ER negative patients, low DNA-PKcs mRNA remains significantly associated with adverse outcome. Conclusions: Our study suggests that low DNA-PKcs expression may have prognostic and predictive significance in breast cancers
The sudden change phenomenon of quantum discord
Even if the parameters determining a system's state are varied smoothly, the
behavior of quantum correlations alike to quantum discord, and of its classical
counterparts, can be very peculiar, with the appearance of non-analyticities in
its rate of change. Here we review this sudden change phenomenon (SCP)
discussing some important points related to it: Its uncovering,
interpretations, and experimental verifications, its use in the context of the
emergence of the pointer basis in a quantum measurement process, its appearance
and universality under Markovian and non-Markovian dynamics, its theoretical
and experimental investigation in some other physical scenarios, and the
related phenomenon of double sudden change of trace distance discord. Several
open questions are identified, and we envisage that in answering them we will
gain significant further insight about the relation between the SCP and the
symmetry-geometric aspects of the quantum state space.Comment: Lectures on General Quantum Correlations and their Applications, F.
F. Fanchini, D. O. Soares Pinto, and G. Adesso (Eds.), Springer (2017), pp
309-33
Salespeople’s Renqing Orientation, Self-esteem, and Selling Behaviors: An Empirical Study in Taiwan
The purpose of this study was to investigate how salespeople’s renqing orientation and self-esteem jointly affect their selling behavior.
Data were obtained from a survey of salespeople from 17 pharmaceutical and consumer-goods companies in Taiwan (n = 216).
Salespeople’s renqing orientation (i.e., their propensity to adhere to the accepted norm of reciprocity) compensates the negative effect of self-esteem on their selling behaviors, such as adaptive selling and hard work.
Our study results underscore the critical role of the character trait of renqing orientation in a culture emphasizing a norm of reciprocity. Therefore, it would be useful to consider a strategy of recruiting salespeople with either a high self-esteem or a combination of high renqing orientation and low self-esteem.
The existing literature of industrial/organizational psychology and marketing primarily relies on constructs that are derived from Western cultural contexts. However, the present paper extended these literatures by investigating the possible joint effects of self-esteem with a trait originated from the Chinese culture on salespeople’s selling behaviors
In support of descriptive studies; relevance to translational research
The contemporary scientific establishment equates hypothesis testing to good science. This stance bypasses the preliminary need to identify a worthwhile hypothesis through rigorous observation of natural processes. If alleviation of human suffering is claimed as the goal of a scientific undertaking, it would be unfair to test a hypothesis whose relevance to human disease has not been satisfactorily proven. Here, we argue that descriptive investigations based on direct human observation should be highly valued and regarded essential for the selection of worthwhile hypotheses while the pursuit of costly scientific investigations without such evidence is a desecration of the cause upon which biomedical research is grounded
- …