Volatility of the Utilities Industry: Its Causal Relationship to Other Nine Industries

The goal of this study is to investigate the causality relationship between the Utilities industry and the nine other industries. Previous literatures show that volatility of stock prices is informative; Granger causality is applied in this research by using of a leveraged bootstrap test developed by Hacker and Hatemi-J (2006) to examine the behavior of the volatility. The results indicate that causality of the volatility of the Utilities industry on the volatility of seven other industries, except the Information Technology and Telecommunication Services industries. The data also suggest that Financials industry has impact on the Utilities industry

Liquefaction Assessment and Lateral Spreading in Nantou, Taiwan

On September 21, 1999, Taiwan was struck by an earthquake, called Chi-Chi earthquake, one of the largest in 100 years. The epicenter was located 12.5 km west of the Sun Moon Lake (Northern Latitude 23.85°) Eastern Longitude 120.78°), with focal depth of 8 km, and magnitude of Mw=7.6 (USGS). This earthquake caused heavy casualties and severe property damages around central Taiwan. It was found that this earthquake resulted in sand boiling, differential settlement on the ground and lateral spreading around part of the Maolou River bank in Nantou City. Field investigation, geological exploration and in situ tests, which include 14 borings with standard penetration tests and 8 cone penetration test soundings, were conducted to demonstrate the soil profiles and to perform soil liquefaction potential assessment. The ground failure due to spreading liquefaction near Maolou River bank was also described. The result revealed that soils about 5-8 meters below the ground surface contains fine to medium silty sand or sandy silt which is the same strata as the highest liquefaction potential based on SPT-N and CPT-qc liquefaction simplified procedures. It is also shown that the critical depth also has the physical properties similar to the boiled sand taken from the sand volcanoes

Models of pre-service teachers' academic achievement: The influence of cognitive motivational variables

Theoretical models were tested using structural equation modeling to evaluate the interrelations among cognitive motivational variables and academic achievement using a sample of 128 predominately Hispanic pre-service teachers enrolled in two undergraduate educational psychology classes. Data were gathered using: (1) a quantitative questionnaire to assess personal control, internal causality, self-efficacy, mastery goal orientation, and final course grade and (2) a problem-solving activity to identify engagement style: action- or process-oriented. The proposed theoretical model produced a poor model fit and thus a modified model was forwarded that directly linked self-efficacy with final course grade rather then mediated by mastery goal orientation. Results supported the modified model and suggested that the cognitive motivational variables under investigation played important roles in predicting students’ grades, with self-efficacy acting as the mediator between both internal causality and personal control and students’ final course grade. This study also demonstrated that the modified model was relatively invariant across gender, ethnicity, and engagement style. Implications for both teacher educators and teachers for understanding the complex links between cognitive motivational variables and academic achievement with a predominately Hispanic sample are discussed

Association Between Platelet Count and Components of Metabolic Syndrome in Geriatric Taiwanese Women

SummaryBackgroundThe growing elderly population in Taiwan, as in many other countries, has resulted in increased importance of the metabolic syndrome (MetS). Although it has been reported in different age groups, the relationship between platelets and MetS remains unknown in geriatric patients.Patients and MethodsWe enrolled 1460 women >65 years old. Women with a known history of diabetes, hyperlipidemia or hypertension or those taking medication for these conditions were all excluded. The women were further divided into quartiles arbitrarily according to platelet count (PC) (PC1–PC4, lowest to highest accordingly).ResultsAmong the MetS components, body mass index (BMI), total cholesterol, low-density lipoprotein cholesterol (LDL-C) and log transformation triglyceride (Log TG) were all significantly higher in the PC4 group (p < 0.05), and they were also positively correlated with PC. However, in multiple regression, BMI became nonsignificant. Both LDL-C and Log TG were the only two factors that remained positively and independently correlated with PC. Compared to PC1, all the other three groups had significantly higher odds ratios for having MetS (2.013, 1.473–2.751; 1.486, 1.081–2.042; 1.537, 1.117–2.114; odds ratios and 95% confidence intervals for PC4, PC3 and PC2, respectively).ConclusionElderly women with MetS had higher PC. Among the five components, TG was positively correlated with PC. There was a positive correlation between PC and LDL-C but not high-density lipoprotein cholesterol. The importance of both lipids might be re-evaluated in the future in older women

Language development, delay and intervention-the views of parents from communities that speech and language therapy managers in England consider to be under-served

Evidence-based practice includes research evidence, clinical expertise and stakeholder perspectives. Stakeholder perspectives are important and include parental ethno-theories, which embrace views about many aspects of speech, language and communication, language development, and interventions. The Developmental Niche Framework provides a useful theory to understand parental beliefs. Ethnotheories, including those about language development, delay and interventions, may vary cross culturally and are less well understood in relation to families who may be considered ‘under-served’ or ‘hard-to-reach’ by speech and language therapy services. Who is considered to be under-served and the reasons why some families are under-served are complex

Bilateral Assessment of Functional Tasks for Robot-assisted Therapy Applications

This article presents a novel evaluation system along with methods to evaluate bilateral coordination of arm function on activities of daily living tasks before and after robot-assisted therapy. An affordable bilateral assessment system (BiAS) consisting of two mini-passive measuring units modeled as three degree of freedom robots is described. The process for evaluating functional tasks using the BiAS is presented and we demonstrate its ability to measure wrist kinematic trajectories. Three metrics, phase difference, movement overlap, and task completion time, are used to evaluate the BiAS system on a bilateral symmetric (bi-drink) and a bilateral asymmetric (bi-pour) functional task. Wrist position and velocity trajectories are evaluated using these metrics to provide insight into temporal and spatial bilateral deficits after stroke. The BiAS system quantified movements of the wrists during functional tasks and detected differences in impaired and unimpaired arm movements. Case studies showed that stroke patients compared to healthy subjects move slower and are less likely to use their arm simultaneously even when the functional task requires simultaneous movement. After robot-assisted therapy, interlimb coordination spatial deficits moved toward normal coordination on functional tasks

COSMOS2020: Exploring the dawn of quenching for massive galaxies at 3 < z < 5 with a new colour selection method

We select and characterise a sample of massive (log(M$_{*}/$M$_{\odot})>10.6$) quiescent galaxies (QGs) at $3<z<5$ in the latest COSMOS2020 catalogue. QGs are selected using a new rest-frame colour selection method, based on their probability of belonging to the quiescent group defined by a Gaussian Mixture Model (GMM) trained on rest-frame colours ($NUV-U, U-V, V-J$) of similarly massive galaxies at $2<z<3$. We calculate the quiescent probability threshold above which a galaxy is classified as quiescent using simulated galaxies from the SHARK semi-analytical model. We find that at $z\geq3$ in SHARK, the GMM/$NUVU-VJ$ method out-performs classical rest-frame $UVJ$ selection and is a viable alternative. We select galaxies as quiescent based on their probability in COSMOS2020 at $3<z<5$, and compare the selected sample to both $UVJ$ and $NUVrJ$ selected samples. We find that although the new selection matches $UVJ$ and $NUVrJ$ in number, the overlap between colour selections is only $\sim50-80\%$, implying that rest-frame colour commonly used at lower redshifts selections cannot be equivalently used at $z>3$. We compute median rest-frame SEDs for our sample and find the median quiescent galaxy at $3<z<5$ has a strong Balmer/4000 Angstrom break, and residual $NUV$ flux indicating recent quenching. We find the number densities of the entire quiescent population (including post-starbursts) more than doubles from $3.5\pm2.2\times10^{-6}$ Mpc$^{-3}$ at $4<z<5$ to $1.4\pm0.4\times10^{-5}$ Mpc$^{-3}$ at $3<z<4$, confirming that the onset of massive galaxy quenching occurs as early as $3<z<5$.Comment: 19 pages, 10 figures + appendix. Accepted for publication in AJ. Both the GMM model and code to calculate quiescent probabilities from rest frame flux densities are made available online at https://github.com/kmlgould/GMM-quiescen

PET/CT Imaging of Zr-89-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys

PURPOSE: Programmed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade has therapeutic effects, the efficacy differs between patients. Factors contributing to this variability are PD-L1 expression levels and immune cells present in tumors. However, it is not well understood how PD-1 expression in the tumor microenvironment impacts immunotherapy response. Thus, imaging of PD-1-expressing immune cells is of interest. This study aims to evaluate the biodistribution of Zirconium-89 (89Zr)-labeled pembrolizumab, a humanized IgG4 kappa monoclonal antibody targeting PD-1, in healthy cynomolgus monkeys as a translational model of tracking PD-1-positive immune cells. PROCEDURES: Pembrolizumab was conjugated with the tetrafluorophenol-N-succinyl desferal-Fe(III) ester (TFP-N-sucDf) and subsequently radiolabeled with 89Zr. Four cynomolgus monkeys with no previous exposure to humanized monoclonal antibodies received tracer only or tracer co-injected with pembrolizumab intravenously over 5 min. Thereafter, a static whole-body positron emission tomography (PET) scan was acquired with 10 min per bed position on days 0, 2, 5, and 7. Image-derived standardized uptake values (SUVmean) were quantified by region of interest (ROI) analysis. RESULTS: 89Zr-N-sucDf-pembrolizumab was synthesized with high radiochemical purity (> 99 %) and acceptable molar activity (> 7 MBq/nmol). In animals dosed with tracer only, 89Zr-N-sucDf-pembrolizumab distribution in lymphoid tissues such as mesenteric lymph nodes, spleen, and tonsils increased over time. Except for the liver, low radiotracer distribution was observed in all non-lymphoid tissue including the lung, muscle, brain, heart, and kidney. When a large excess of pembrolizumab was co-administered with a radiotracer, accumulation in the lymph nodes, spleen, and tonsils was reduced, suggestive of target-mediated accumulation. CONCLUSIONS: 89Zr-N-sucDf-pembrolizumab shows preferential uptake in the lymphoid tissues including the lymph nodes, spleen, and tonsils. 89Zr-N-sucDf-pembrolizumab may be useful in tracking the distribution of a subset of immune cells in non-human primates and humans. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02760225

A narrative inquiry into the identity formation of Chinese doctoral students in relation to study abroad

The present study explores a topic which has been under-studied to date, namely the identity formation of Chinese PhD students in relation to study abroad. Underpinned by Giddens' (1991) "reflexive project of the self", which privileges agency and reflexivity, and using a narrative inquiry approach, it presents four students' 'stories' collected through semi-structured interviews and focus group discussions in the form of a trajectory of development fro past to future. In building a picture of theways in which students' self-identity is shaped by and shapes their experience of study abroad, the stories illustrate individual agency, motivation, self-determination and reflexivity. In doing so, they challenge the essentialised view of Chinese students as a homogeneous and sometimes problematic group and point to implications for action by the host institutions

Clubroot (Plasmodiophora brassicae Woronin): an agricultural and biological challenge worldwide

Clubroot disease and the causal microbe Plasmodiophora brassicae offer abundant challenges to agriculturists and biological scientists. This microbe is well fitted for the environments which it inhabits. Plasmodiophora brassicae exists in soil as microscopic well protected resting spores and then grows actively and reproduces while shielded inside the roots of host plants. The pathogen is active outside the host for only short periods. Consequently, scientific studies are made challenging by the biological context of the host and pathogen and the technology required to investigate and understand that relationship. Controlling clubroot disease is a challenge for farmers, crop consultants and plant pathology practitioners because of the limited options which are available. Full symptom expression happens solely in members of the Brassicaceae family. Currently, only a few genes expressing strong resistance to P. brassicae are known and readily available. Agrochemical control is similarly limited by difficulties in molecule formulation which combines efficacy with environmental acceptability. Manipulation of husbandry encouraging improvements in soil structure, texture, nutrient composition and moisture content can reduce populations of P. brassicae. Integrating such strategies with rotation and crop management will reduce but not eliminate this disease. There are indications that forms of biological competition may be mobilised as additions to integrated control strategies. The aim of this review is to chart key themes in the development of scientific biological understanding of this host-pathogen relationship by offering signposts to grapple with clubroot disease which devastates crops and their profitability. Particular attention is given to the link between soil and nutrient chemistry and activity of this microbe