1,422 research outputs found
Quantifying learning: measuring student outcomes in higher education in England
Since 2014, the government in England has undertaken a programme of work to explore the measurement of learning gain in undergraduate education. This is part of a wider neoliberal agenda to create a market in higher education, with student outcomes featuring as a key construct of value for money. The Higher Education Funding Council for England (subsequently dismantled) invested £4 million in funding 13 pilot projects to develop and test instruments and methods for measuring learning gain, with approaches largely borrowed from the US. Whilst measures with validity in specific disciplinary or institutional contexts were developed, a robust single instrument or measure has failed to emerge. The attempt to quantify learning represented by this initiative should spark debate about the rationale for quantification—whether it is for accountability, measuring performance, assuring quality or for the enhancement of teaching, learning and the student experience. It also raises profound questions about who defines the purpose of higher education; and whether it is those inside or outside of the academy who have the authority to decide the key learning outcomes of higher education. This article argues that in focusing on the largely technical aspects of the quantification of learning, government-funded attempts in England to measure learning gain have overlooked fundamental questions about the aims and values of higher education. Moreover, this search for a measure of learning gain represents the attempt to use quantification to legitimize the authority to define quality and appropriate outcomes in higher education
Tackling climate change with blockchain
Concern about the carbon footprint of Bitcoin is not holding back blockchain developers from leveraging the technology for action on climate change. Although blockchain technology is enabling individuals and businesses to manage their carbon emissions, the social and environmental costs and benefits of doing so remain unclear
Asymmetric triplex metallohelices with high and selective activity against cancer cells
Small cationic amphiphilic α-helical peptides are emerging as agents for the treatment of cancer and infection, but they are costly and display unfavourable pharmacokinetics. Helical coordination complexes may offer a three-dimensional scaffold for the synthesis of mimetic architectures. However, the high symmetry and modest functionality of current systems offer little scope to tailor the structure to interact with specific biomolecular targets, or to create libraries for phenotypic screens. Here, we report the highly stereoselective asymmetric self-assembly of very stable, functionalized metallohelices. Their anti-parallel head-to-head-to-tail ‘triplex’ strand arrangement creates an amphipathic functional topology akin to that of the active sub-units of, for example, host-defence peptides and p53. The metallohelices display high, structure-dependent toxicity to the human colon carcinoma cell-line HCT116 p53++, causing dramatic changes in the cell cycle without DNA damage. They have lower toxicity to human breast adenocarcinoma cells (MDA-MB-468) and, most remarkably, they show no significant toxicity to the bacteria methicillin-resistant Staphylococcus aureus and Escherichia coli.
At a glanc
The Archaeology of the New York African Burial Ground (Pt. 1)
This volume is one of three disciplinary volumes on the New York African Burial Ground Project. One volume focuses on the skeletal biological analysis of the remains recovered from the site (see Volume 1 of this series, Skeletal Biology of the New York African Burial Ground [Blakey and Rankin-Hill 2009a]). Another focuses on the documentary history, from a diasporic perspective, of Africans who lived and died in early New York (see Volume 3 of this series, Historical Perspectives of the African Burial Ground: New York Blacks and the Diaspora [Medford 2009]). The present volume, consisting of three parts, presents the archaeological research on the New York African Burial Ground. General background on the New York African Burial Ground project is presented in the beginning of the skeletal biology component volume (Blakey and Rankin-Hill 2009a). Here we provide background information that is specifically relevant to the excavated site, the archaeological fieldwork undertaken in 1991–1992 (its planning, personnel, extent, duration, termination, etc.), and the analysis and disposition of nonskeletal material from the excavation.https://scholarworks.wm.edu/asbook/1043/thumbnail.jp
The Archaeology of the New York African Burial Ground (Pt. 2): Descriptions of Burials
https://scholarworks.wm.edu/asbook/1044/thumbnail.jp
Optically pure heterobimetallic helicates from self-assembly and click strategies
Single diastereomer, diamagnetic, octahedral Fe(II) tris chelate complexes are synthesised that contain three pendant pyridine proligands pre-organised for coordination to a second metal. They bind Cu(I) and Ag(I) with coordination geometry depending on the identity of the metal and the detail of the ligand structure, but for example homohelical (ΔFe,ΔCu) configured systems with unusual trigonal planar Cu cations are formed exclusively in solution as shown by VT-NMR and supported by DFT calculations. Similar heterobimetallic tris(triazole) complexes are synthesised via clean CuAAC reactions at a tris(alkynyl) complex, although here the configurations of the two metals differ (ΔFe,ΛCu), leading to the first optically pure heterohelicates. A second series of Fe complexes perform less well in either strategy as a result of lack of preorganisation
A fast multi-dimensional magnetohydrodynamic formulation of the transition region adaptive conduction (TRAC) method
The research leading to these results has received funding from the UK Science and Technology Facilities Council (consolidated grant ST/N000609/1), the European Union Horizon 2020 research and innovation programme (grant agreement No. 647214). IDM received funding from the Research Council of Norway through its Centres of Excellence scheme, project number 262622. CDJ acknowledges support from the International Space Science Institute (ISSI), Bern, Switzerland to the International Teams on “Observed Multi-Scale Variability of Coronal Loops as a Probe of Coronal Heating” and “Interrogating Field-Aligned Solar Flare Models: Comparing, Contrasting and Improving”.We have demonstrated that the transition region adaptive conduction (TRAC) method permits fast and accurate numerical solutions of the field-aligned hydrodynamic equations, successfully removing the influence of numerical resolution on the coronal density response to impulsive heating. This is achieved by adjusting the parallel thermal conductivity, radiative loss, and heating rates to broaden the transition region (TR), below a global cutoff temperature, so that the steep gradients are spatially resolved even when using coarse numerical grids. Implementing the original 1D formulation of TRAC in multi-dimensional magnetohydrodynamic (MHD) models would require tracing a large number of magnetic field lines at every time step in order to prescribe a global cutoff temperature to each field line. In this paper, we present a highly efficient formulation of the TRAC method for use in multi-dimensional MHD simulations, which does not rely on field line tracing. In the TR, adaptive local cutoff temperatures are used instead of global cutoff temperatures to broaden any unresolved parts of the atmosphere. These local cutoff temperatures are calculated using only local grid cell quantities, enabling the MHD extension of TRAC to efficiently account for the magnetic field evolution, without tracing field lines. Consistent with analytical predictions, we show that this approach successfully preserves the properties of the original TRAC method. In particular, the total radiative losses and heating remain conserved under the MHD formulation. Results from 2D MHD simulations of impulsive heating in unsheared and sheared arcades of coronal loops are also presented. These simulations benchmark the MHD TRAC method against a series of 1D models and demonstrate the versatility and robustness of the method in multi-dimensional magnetic fields. We show, for the first time, that pressure differences, generated during the evaporation phase of impulsive heating events, can produce current layers that are significantly narrower than the transverse energy deposition.PostprintPeer reviewe
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