Workshop on the Polar Regions of Mars: Geology, Glaciology, and Climate History, part 1

Papers and abstract of papers presented at the workshop are presented. Some representative titles are as follows: Glaciation in Elysium; Orbital, rotational, and climatic interactions; Water on Mars; Rheology of water-silicate mixtures at low temperatures; Evolution of the Martian atmosphere (the role of polar caps); Is CO2 ice permanent; Dust transport into Martian polar latitudes; Mars observer radio science (MORS) observations in polar regions; and Wind transport near the poles of Mars (timescales of changes in deposition and erosion)

Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes

Abstract Diabetic retinopathy (DR) is a major cause of blindness in working adults in the industrialized world. In addition to vision loss caused by macular edema and pathological angiogenesis, DR patients often exhibit neuronal dysfunction on electrophysiological testing, suggesting that there may be an independent neuronal phase of disease that precedes vascular disease. Given the tremendous metabolic requirements of the retina and photoreceptors in particular, we hypothesized that derangements in metabolic regulation may accelerate retinal dysfunction in diabetes. As such, we induced hyperglycemia with streptozotocin in mice with monoallelic Nampt deletion from rod photoreceptors, mice lacking SIRT3, and mice lacking SIRT5 and tested multiple components of retinal function with electroretinography. None of these mice exhibited accelerated retinal dysfunction after induction of hyperglycemia, consistent with normal-appearing retinal morphology in hyperglycemic Sirt3 −/− or Sirt5 −/− mice. However, mice lacking both SIRT3 and SIRT5 (Sirt3 −/− Sirt5 −/− mice) exhibited significant evidence of inner retinal dysfunction after induction of hyperglycemia compared to hyperglycemic littermate controls, although this dysfunction was not accompanied by gross morphological changes in the retina. These results suggest that SIRT3 and SIRT5 may be involved in regulating neuronal dysfunction in DR and provide a foundation for future studies investigating sirtuin-based therapies

Differential Effects of Race and Poverty on Ambulatory Care Sensitive Conditions

This study is a continuation of an earlier study that examined hospitalization rates for ambulatory care sensitive (ACS) conditions, as a proxy for quality of care, and found evidence of a racial disparity among African American and White Medicare beneficiaries. The current study sought to determine whether neighborhood socioeconomic status (SES) explained this disparity. Differences in rates of ACS hospitalizations by race were assessed using Cochran-Mantel Haenszel tests and Poisson regression. Unadjusted rate ratios for ACS hospitalization for African Americans vs. Whites were found to be higher in low poverty areas (rate ratio (RR)=1.13; 95% CI (1.08, 1.17)) than in high poverty areas (RR=0.97; 95% CI (0.89, 1.05)). After controlling for various indicators of area SES in multivariate analyses race differences in ACS hospitalization rates persisted. Rural neighborhoods and those with higher percent of non-high school graduates were associated with greater risk of ACS hospitalizations

Steady-state MreB helices inside bacteria: dynamics without motors

Within individual bacteria, we combine force-dependent polymerization dynamics of individual MreB protofilaments with an elastic model of protofilament bundles buckled into helical configurations. We use variational techniques and stochastic simulations to relate the pitch of the MreB helix, the total abundance of MreB, and the number of protofilaments. By comparing our simulations with mean-field calculations, we find that stochastic fluctuations are significant. We examine the quasi-static evolution of the helical pitch with cell growth, as well as timescales of helix turnover and denovo establishment. We find that while the body of a polarized MreB helix treadmills towards its slow-growing end, the fast-growing tips of laterally associated protofilaments move towards the opposite fast-growing end of the MreB helix. This offers a possible mechanism for targeted polar localization without cytoplasmic motor proteins.Comment: 7 figures, 1 tabl

Independent Orbiter Assessment (IOA): Analysis of the instrumentation subsystem

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. The IOA approach features a top-down analysis of the hardware to determine failure modes, criticality, and potential critical items. To preserve independence, this analysis was accomplished without reliance upon the results contained within the NASA FMEA/CIL documentation. The independent analysis results for the Instrumentation Subsystem are documented. The Instrumentation Subsystem (SS) consists of transducers, signal conditioning equipment, pulse code modulation (PCM) encoding equipment, tape recorders, frequency division multiplexers, and timing equipment. For this analysis, the SS is broken into two major groupings: Operational Instrumentation (OI) equipment and Modular Auxiliary Data System (MADS) equipment. The OI equipment is required to acquire, condition, scale, digitize, interleave/multiplex, format, and distribute operational Orbiter and payload data and voice for display, recording, telemetry, and checkout. It also must provide accurate timing for time critical functions for crew and payload specialist use. The MADS provides additional instrumentation to measure and record selected pressure, temperature, strain, vibration, and event data for post-flight playback and analysis. MADS data is used to assess vehicle responses to the flight environment and to permit correlation of such data from flight to flight. The IOA analysis utilized available SS hardware drawings and schematics for identifying hardware assemblies and components and their interfaces. Criticality for each item was assigned on the basis of the worst-case effect of the failure modes identified

Persistence in the zero-temperature dynamics of the QQ-states Potts model on undirected-directed Barab\'asi-Albert networks and Erd\"os-R\'enyi random graphs

The zero-temperature Glauber dynamics is used to investigate the persistence probability $P(t)$ in the Potts model with $Q=3,4,5,7,9,12,24,64, 128$, $256, 512, 1024,4096,16384$,..., $2^{30}$ states on {\it directed} and {\it undirected} Barab\'asi-Albert networks and Erd\"os-R\'enyi random graphs. In this model it is found that $P(t)$ decays exponentially to zero in short times for {\it directed} and {\it undirected} Erd\"os-R\'enyi random graphs. For {\it directed} and {\it undirected} Barab\'asi-Albert networks, in contrast it decays exponentially to a constant value for long times, i.e, $P(\infty)$ is different from zero for all $Q$ values (here studied) from $Q=3,4,5,..., 2^{30}$; this shows "blocking" for all these $Q$ values. Except that for $Q=2^{30}$ in the {\it undirected} case $P(t)$ tends exponentially to zero; this could be just a finite-size effect since in the other "blocking" cases you may have only a few unchanged spins.Comment: 14 pages, 8 figures for IJM

Comprehensive Observations of a Solar Minimum CME with STEREO

We perform the first kinematic analysis of a CME observed by both imaging and in situ instruments on board STEREO, namely the SECCHI, PLASTIC, and IMPACT experiments. Launched on 2008 February 4, the CME is tracked continuously from initiation to 1 AU using the SECCHI imagers on both STEREO spacecraft, and is then detected by the PLASTIC and IMPACT particle and field detectors on board STEREO-B. The CME is also detected in situ by ACE and SOHO/CELIAS at Earth's L1 Lagrangian point. The CME hits STEREO-B, ACE, and SOHO on 2008 February 7, but misses STEREO-A entirely. This event provides a good example of just how different the same event can look when viewed from different perspectives. We also demonstrate many ways in which the comprehensive and continuous coverage of this CME by STEREO improves confidence in our assessment of its kinematic behavior, with potential ramifications for space weather forecasting. The observations provide several lines of evidence in favor of the observable part of the CME being narrow in angular extent, a determination crucial for deciding how best to convert observed CME elongation angles from Sun-center to actual Sun-center distances.Comment: 27 pages, 10 figures, AASTEX v5.2, accepted by Ap

Proton transport and torque generation in rotary biomotors

We analyze the dynamics of rotary biomotors within a simple nano-electromechanical model, consisting of a stator part and a ring-shaped rotor having twelve proton-binding sites. This model is closely related to the membrane-embedded F$_0$ motor of adenosine triphosphate (ATP) synthase, which converts the energy of the transmembrane electrochemical gradient of protons into mechanical motion of the rotor. It is shown that the Coulomb coupling between the negative charge of the empty rotor site and the positive stator charge, located near the periplasmic proton-conducting channel (proton source), plays a dominant role in the torque-generating process. When approaching the source outlet, the rotor site has a proton energy level higher than the energy level of the site, located near the cytoplasmic channel (proton drain). In the first stage of this torque-generating process, the energy of the electrochemical potential is converted into potential energy of the proton-binding sites on the rotor. Afterwards, the tangential component of the Coulomb force produces a mechanical torque. We demonstrate that, at low temperatures, the loaded motor works in the shuttling regime where the energy of the electrochemical potential is consumed without producing any unidirectional rotation. The motor switches to the torque-generating regime at high temperatures, when the Brownian ratchet mechanism turns on. In the presence of a significant external torque, created by ATP hydrolysis, the system operates as a proton pump, which translocates protons against the transmembrane potential gradient. Here we focus on the F$_0$ motor, even though our analysis is applicable to the bacterial flagellar motor.Comment: 24 pages, 5 figure

First Stereoscopic Coronal Loop Reconstructions from Stereo Secchi Images

We present the first reconstruction of the three-dimensional shape of magnetic loops in an active region from two different vantage points based on simultaneously recorded images. The images were taken by the two EUVI telescopes of the SECCHI instrument onboard the recently launched STEREO spacecraft when the heliocentric separation of the two space probes was 12 degrees. We demostrate that these data allow to obtain a reliable three-dimensional reconstruction of sufficiently bright loops. The result is compared with field lines derived from a coronal magnetic field model extrapolated from a photospheric magnetogram recorded nearly simultaneously by SOHO/MDI. We attribute discrepancies between reconstructed loops and extrapolated field lines to the inadequacy of the linear force-free field model used for the extrapolation.Comment: 6 pages, 5 figure