517 research outputs found
Hydrogen Bonding Effects in Anion Binding Calixarenes
A series of disubstituted urea, thiourea and dansyl amide calix[4]arene based anion receptors have been prepared and characterised by X-ray crystallography. The structures show a fine balance of intramolecular urea α-tape, and ureacalixarene phenolic oxygen atom hydrogen bonding patterns. Both motifs are in competition with the anion binding behaviour of the compounds in solution
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.
The specificity of antibody (Ab) responses depends on focusing helper T (Th) lymphocyte signals to suitable B lymphocytes capable of binding foreign antigens (Ags), and away from nonspecific or self-reactive B cells. To investigate the molecular mechanisms that prevent the activation of self-reactive B lymphocytes, the activation requirements of B cells specific for the Ag hen egg lysozyme (HEL) obtained from immunoglobulin (Ig)-transgenic mice were compared with those of functionally tolerant B cells isolated from Ig-transgenic mice which also express soluble HEL. To eliminate the need for surface (s)Ig-mediated Ag uptake and presentation and allow the effects of sIg signaling to be studied in isolation, we assessed the ability of allogeneic T cells from bm12 strain mice to provide in vivo help to C57BL/6 strain-transgenic B cells. Interestingly, non-tolerant Ig-transgenic B cells required both allogeneic Th cells and binding of soluble HEL for efficient activation and Ab production. By contrast, tolerant self-reactive B cells from Ig/HEL double transgenic mice responded poorly to the same combination of allogeneic T cells and soluble HEL. The tolerant B cells were nevertheless normally responsive to stimulation with interleukin 4 and anti-CD40 Abs in vitro, suggesting that they retained the capacity to respond to mediators of T cell help. However, the tolerant B cells exhibited a proximal block in the sIg signaling pathway which prevented activation of receptor-associated tyrosine kinases in response to the binding of soluble HEL. The functional significance of this sIg signaling defect was confirmed by using a more potent membrane-bound form of HEL capable of triggering sIg signaling in tolerant B cells, which markedly restored their ability to collaborate with allogeneic Th cells and produce Ab. These findings indicate that Ag-specific B cells require two signals for mounting a T cell-dependent Ab response and identify regulation of sIg signaling as a mechanism for controlling self-reactive B cells
Magmatism and metamorphism at ca. 1.45 Ga in the northern Gawler Craton: the Australian record of rifting within Nuna (Columbia)
U–Pb monazite and zircon geochronology and calculated metamorphic phase diagrams from drill holes in the northern Gawler Craton, southern Australia, reveal the presence of ca. 1.45 Ga magmatism and metamorphism. Magmatism and granulite facies metamorphism of this age has not previously been recognised in the Gawler Craton. The magmatic rocks have steep LREE-enriched patterns and high Ga/Al values, suggesting they are A-type granites. Calculated metamorphic forward models suggest that this event was associated with high apparent thermal gradients and reached pressures of 3.2–5.4 kbar and temperatures of 775–815 °C. The high apparent thermal gradients may reflect pluton-enhanced metamorphism, consistent with the presence of A-type granites. The recognition of ca. 1.45 Ga tectonism in the northern Gawler Craton is added to a compilation of ca. 1.50–1.40 Ga magmatism, shear zone reactivation, rift basin development and isotope resetting throughout the South and North Australian Cratons that shows that this event was widespread in eastern Proterozoic Australia. This event is stylistically similar to ca. 1.45 Ga A-type magmatism and high thermal gradient metamorphism in Laurentia in this interval and provides further support for a connection between Australia and Laurentia during the Mesoproterozoic. The tectonic setting of the 1.50–1.40 Ga event is unclear but may record rifting within the Nuna (or Columbia) supercontinent, or a period of intracontinental extension within a long-lived convergent setting.Laura J. Morrissey, Karin M. Barovich, Martin Hand, Katherine E. Howard, Justin L. Payn
A Comparison of Solar Cycle Variations in the Equatorial Rotation Rates of the Sun's Subsurface, Surface, Corona, and Sunspot Groups
Using the Solar Optical Observing Network (SOON) sunspot-group data for the
period 1985-2010, the variations in the annual mean equatorial-rotation rates
of the sunspot groups are determined and compared with the known variations in
the solar equatorial-rotation rates determined from the following data: i) the
plasma rotation rates at 0.94Rsun, 0.95Rsun,...,1.0Rsun measured by Global
Oscillation Network Group (GONG) during the period 1995-2010, ii) the data on
the soft X-ray corona determined from Yohkoh/SXT full disk images for the years
1992-2001, iii) the data on small bright coronal structures (SBCS) which were
traced in Solar and Heliospheric Observatory (SOHO)/EIT images during the
period 1998-2006, and iv) the Mount Wilson Doppler-velocity measurements during
the period 1986-2007. A large portion (up to approximate 30 deg latitude) of
the mean differential-rotation profile of the sunspot groups lies between those
of the internal differential-rotation rates at 0.94Rsun and 0.98Rsun.The
variation in the yearly mean equatorial-rotation rate of the sunspot groups
seems to be lagging that of the equatorial-rotation rate determined from the
GONG measurements by one to two years.The amplitude of the latter is very
small.The solar-cycle variation in the equatorial-rotation rate of the solar
corona closely matches that determined from the sunspot-group data.The
variation in the equatorial-rotation rate determined from the Mount Wilson
Doppler-velocity data closely resembles the corresponding variation in the
equatorial-rotation rate determined from the sunspot-group data that included
the values of the abnormal angular motions (> 3 deg per day) of the sunspot
groups. Implications of these results are pointed out.Comment: 22 pages, 10 figures, accepted by Solar Physic
The G-O Rule and Waldmeier Effect in the Variations of the Numbers of Large and Small Sunspot Groups
We have analysed the combined Greenwich and Solar Optical Observing Network
(SOON) sunspot group data during the period of 1874-2011 and determined
variations in the annual numbers (counts) of the small, large and big sunspot
groups (these classifications are made on the basis of the maximum areas of the
sunspot groups). We found that the amplitude of an even-numbered cycle of the
number of large groups is smaller than that of its immediately following
odd-numbered cycle. This is consistent with the well known Gnevyshev and Ohl
rule or G-O rule of solar cycles, generally described by using the Zurich
sunspot number (Rz). During cycles 12-21 the G-O rule holds good for the
variation in the number of small groups also, but it is violated by cycle pair
(22, 23) as in the case of Rz. This behaviour of the variations in the small
groups is largely responsible for the anomalous behaviour of Rz in cycle pair
(22, 23). It is also found that the amplitude of an odd-numbered cycle of the
number of small groups is larger than that of its immediately following
even-numbered cycle. This can be called as `reverse G-O rule'. In the case of
the number of the big groups, both cycle pairs (12, 13) and (22, 23) violated
the G-O rule. In many cycles the positions of the peaks of the small, large,
and big groups are different and considerably differ with respect to the
corresponding positions of the Rz peaks. In the case of cycle 23, the
corresponding cycles of the small and large groups are largely symmetric/less
asymmetric (Waldmeier effect is weak/absent) with their maxima taking place two
years later than that of Rz. The corresponding cycle of the big groups is more
asymmetric (strong Waldmeier effect) with its maximum epoch taking place at the
same time as that of Rz.Comment: 13 pages, 5 figures, 1 table, accepted by Solar Physic
Perception of Relative Depth Interval: Systematic Biases in Perceived Depth
Given an estimate of the binocular disparity between a pair of points and an estimate of the viewing distance, or knowledge of eye position, it should be possible to obtain an estimate of their depth separation. Here we show that, when points are arranged in different vertical geometric configurations across two intervals, many observers find this task difficult. Those who can do the task tend to perceive the depth interval in one configuration as very different from depth in the other configuration. We explore two plausible explanations for this effect. The first is the tilt of the empirical vertical horopter: Points perceived along an apparently vertical line correspond to a physical line of points tilted backwards in space. Second, the eyes can rotate in response to a particular stimulus. Without compensation for this rotation, biases in depth perception would result. We measured cyclovergence indirectly, using a standard psychophysical task, while observers viewed our depth configuration. Biases predicted from error due either to cyclovergence or to the tilted vertical horopter were not consistent with the depth configuration results. Our data suggest that, even for the simplest scenes, we do not have ready access to metric depth from binocular disparity.</jats:p
An analysis of the FIR/RADIO Continuum Correlation in the Small Magellanic Cloud
The local correlation between far-infrared (FIR) emission and radio-continuum
(RC) emission for the Small Magellanic Cloud (SMC) is investigated over scales
from 3 kpc to 0.01 kpc. Here, we report good FIR/RC correlation down to ~15 pc.
The reciprocal slope of the FIR/RC emission correlation (RC/FIR) in the SMC is
shown to be greatest in the most active star forming regions with a power law
slope of ~1.14 indicating that the RC emission increases faster than the FIR
emission. The slope of the other regions and the SMC are much flatter and in
the range of 0.63-0.85. The slopes tend to follow the thermal fractions of the
regions which range from 0.5 to 0.95. The thermal fraction of the RC emission
alone can provide the expected FIR/RC correlation. The results are consistent
with a common source for ultraviolet (UV) photons heating dust and Cosmic Ray
electrons (CRe-s) diffusing away from the star forming regions. Since the CRe-s
appear to escape the SMC so readily, the results here may not provide support
for coupling between the local gas density and the magnetic field intensity.Comment: 19 pages, 7 Figure
High-contrast imaging constraints on gas giant planet formation - The Herbig Ae/Be star opportunity
Planet formation studies are often focused on solar-type stars, implicitly
considering our Sun as reference point. This approach overlooks, however, that
Herbig Ae/Be stars are in some sense much better targets to study planet
formation processes empirically, with their disks generally being larger,
brighter and simply easier to observe across a large wavelength range. In
addition, massive gas giant planets have been found on wide orbits around early
type stars, triggering the question if these objects did indeed form there and,
if so, by what process. In the following I briefly review what we currently
know about the occurrence rate of planets around intermediate mass stars,
before discussing recent results from Herbig Ae/Be stars in the context of
planet formation. The main emphasis is put on spatially resolved polarized
light images of potentially planet forming disks and how these images - in
combination with other data - can be used to empirically constrain (parts of)
the planet formation process. Of particular interest are two objects, HD100546
and HD169142, where, in addition to intriguing morphological structures in the
disks, direct observational evidence for (very) young planets has been
reported. I conclude with an outlook, what further progress we can expect in
the very near future with the next generation of high-contrast imagers at 8-m
class telescopes and their synergies with ALMA.Comment: Accepted by Astrophysics and Space Science as invited short review in
special issue about Herbig Ae/Be stars; 12 pages incl. 5 figures, 2 tables
and reference
Transitions from Ideal to Intermediate Cholesterol Levels may vary by Cholesterol Metric
To examine the ability of total cholesterol (TC), a low-density lipoprotein cholesterol (LDL-C) proxy widely used in public health initiatives, to capture important population-level shifts away from ideal and intermediate LDL-C throughout adulthood. We estimated age (≥20 years)-, race/ethnic (Caucasian, African American, and Hispanic/Latino)-, and sex- specific net transition probabilities between ideal, intermediate, and poor TC and LDL-C using National Health and Nutrition Examination Survey (2007–2014; N = 13,584) and Hispanic Community Health Study/Study of Latinos (2008–2011; N = 15,612) data in 2016 and validated and calibrated novel Markov-type models designed for cross-sectional data. At age 20, >80% of participants had ideal TC, whereas the race/ethnic- and sex-specific prevalence of ideal LDL-C ranged from 39.2%-59.6%. Net transition estimates suggested that the largest one-year net shifts away from ideal and intermediate LDL-C occurred approximately two decades earlier than peak net population shifts away from ideal and intermediate TC. Public health and clinical initiatives focused on monitoring TC in middle-adulthood may miss important shifts away from ideal and intermediate LDL-C, potentially increasing the duration, perhaps by decades, that large segments of the population are exposed to suboptimal LDL-C
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